1.1.1.3: homoserine dehydrogenase
This is an abbreviated version!
For detailed information about homoserine dehydrogenase, go to the full flat file.
Word Map on EC 1.1.1.3
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1.1.1.3
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l-threonine
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threonine-sensitive
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corynebacterium
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glutamicum
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l-lysine
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semialdehyde
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dihydrodipicolinate
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l-isoleucine
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brevibacterium
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aspartate-derived
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2.7.2.4
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i-homoserine
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rhodospirillum
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lysine-sensitive
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lactofermentum
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feedback-insensitive
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feedback-resistant
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synthesis
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drug development
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agriculture
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pharmacology
- 1.1.1.3
- l-threonine
-
threonine-sensitive
- corynebacterium
- glutamicum
- l-lysine
- semialdehyde
- dihydrodipicolinate
- l-isoleucine
- brevibacterium
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aspartate-derived
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2.7.2.4
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i-homoserine
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rhodospirillum
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lysine-sensitive
- lactofermentum
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feedback-insensitive
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feedback-resistant
- synthesis
- drug development
- agriculture
- pharmacology
Reaction
Synonyms
AK-HDH, AK-HSD-1, AK-HSDH, AK-HseDH, aspartate kinase-homoserine dehydrogenase, aspartokinase-homoserine dehydrogenase I, bifunctional aspartate kinase-homoserine dehydrogenase, BsHSD, HDH, hom, hom-1, Hom6, homoserine dehydrogenase 1, homoserine dehydrogenase 2, HSD, HSDH, HseDH, More, orf19.2951, PbHSD, SACOL1362, StHSD, thrA, TM_0547, TTHA0489, TtHSD
ECTree
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KM Value
KM Value on EC 1.1.1.3 - homoserine dehydrogenase
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11.6
L-aspartate
pH 8.0, 37°C, purified recombinant soluble enzyme
0.098
L-aspartate 4-semialdehyde
cosubstrate NADPH, pH 8.0, 25°C
0.15
L-aspartate 4-semialdehyde
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threonine-resistant enzyme, pH and temperature not specified in the publication
0.25
L-aspartate 4-semialdehyde
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threonine-sensitive enzyme, pH and temperature not specified in the publication
0.569
L-aspartate 4-semialdehyde
cosubstrate NADH, pH 8.0, 25°C
0.845
L-aspartate 4-semialdehyde
cosubstrate NADH, pH 8.0, 25°C
1.19
L-aspartate 4-semialdehyde
cosubstrate NADH, pH 8.0, 25°C
1.25
L-aspartate 4-semialdehyde
cosubstrate NADPH, pH 8.0, 25°C
2.19
L-aspartate 4-semialdehyde
cosubstrate NADPH, pH 8.0, 25°C
0.41
L-homoserine
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recombinant hybrid bifunctional holoenzyme AKIII-HDHI+ containing the interface region, homoserine dehydrogenase activity
0.68
L-homoserine
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recombinant isolated catalytic HDH-domain containing the interface region, homoserine dehydrogenase activity
1.2
L-homoserine
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recombinant wild-type bifunctional holoenzyme, homoserine dehydrogenase activity
5.2
L-homoserine
pH 8.0, 37°C, purified recombinant soluble enzyme
17.2
L-homoserine
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recombinant isolated catalytic HDH-domain not containing the interface region, homoserine dehydrogenase activity
0.46
NADH
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isoenzyme II, at pH 7.5, temperature not specified in the publication
0.036
NADPH
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threonine-resistant enzyme, pH and temperature not specified in the publication
0.04
NADPH
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threonine-sensitive enzyme, pH and temperature not specified in the publication
additional information
additional information
Michaelis-Menten steady-state kinetics
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additional information
additional information
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Michaelis-Menten steady-state kinetics
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additional information
additional information
enzyme HseDH shows typical Michaelis-Menten kinetics for oxidation
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additional information
additional information
kinetic profile
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additional information
additional information
the binding of L-homoserine is the rate limiting factor for L-homoserine oxidation, Michaelis-Menten kinetics, overview
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additional information
additional information
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the binding of L-homoserine is the rate limiting factor for L-homoserine oxidation, Michaelis-Menten kinetics, overview
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