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1.1.1.299: malate dehydrogenase [NAD(P)+]

This is an abbreviated version!
For detailed information about malate dehydrogenase [NAD(P)+], go to the full flat file.

Word Map on EC 1.1.1.299

Reaction

(S)-malate
+
NAD(P)+
=
oxaloacetate
+
NAD(P)H
+
H+

Synonyms

LDH-like MalDH, MDH II, NAD(P)-dependent malate dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.299 malate dehydrogenase [NAD(P)+]

Systematic Name

Systematic Name on EC 1.1.1.299 - malate dehydrogenase [NAD(P)+]

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SYSTEMATIC NAME
IUBMB Comments
(S)-malate:NAD(P)+ oxidoreductase
This enzyme, which was characterized from the methanogenic archaeon Methanobacterium thermoautotrophicum, catalyses only the reduction of oxaloacetate, and can use NAD+ and NADP+ with similar specific activity [1]. Different from EC 1.1.1.37 (malate dehydrogenase (NAD+)), EC 1.1.1.82 (malate dehydrogenase (NADP+)) and EC 1.1.5.4 (malate dehydrogenase (quinone)).