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1.1.1.284: S-(hydroxymethyl)glutathione dehydrogenase

This is an abbreviated version!
For detailed information about S-(hydroxymethyl)glutathione dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.284

Reaction

S-(hydroxymethyl)glutathione
+
NAD(P)+
=
S-formylglutathione
+
NAD(P)H
+
H+

Synonyms

ADH III, ADH3, ADH4, ADH5, AdhC, alcohol dehydrogenase 3, alcohol dehydrogenase 5, alcohol dehydrogenase class III, alcohol dehydrogenase class-3, Alcohol dehydrogenase SFA, AN7632.2, AtGSNOR, c-ADH, carbonyl reductase 1, CBR1, class III ADH, class III alcohol dehydrogenase, dehydrogenase, formaldehyde, EC 1.2.1.1, FALDH, FDH, FLD, FldA, formaldehyde dehydrogenase, formaldehyde dehydrogenase (glutathione), formic dehydrogenase, FrxA, GD-FAlDH, GFD, glutathione (GSH)-dependent formaldehyde dehydrogenase, glutathione-dependent alcohol dehydrogenase, Glutathione-dependent formaldehyde dehydrogenase, GS-FDH, GSH-FDH, GSNO reductase, GSNO-R, GSNOR, GSNOR1, HMGSH dehydrogenase, HOT5, MGG_06011, NAD- and glutathione-dependent formaldehyde dehydrogenase, NAD-dependent formaldehyde dehydrogenase, NAD-linked formaldehyde dehydrogenase, NADH-GSNO oxidoreductase, nitroreductase, NTRA, Os02g0815500, Os02G57040, OsGSNOR, PmFLD1, PmGSNOR, S-nitrosoglutathione reductase, SA0UHSC_00833, SFA1, SlGSNOR, SoGSNOR, Tc-GFD

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.284 S-(hydroxymethyl)glutathione dehydrogenase

Natural Substrates Products

Natural Substrates Products on EC 1.1.1.284 - S-(hydroxymethyl)glutathione dehydrogenase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
12-hydroxydodecanoic acid + glutathione + NAD+
S-(11-carboxy)undecanyl-glutathione + NADH + H+
show the reaction diagram
-
best substrate for ADH3
-
-
?
formaldehyde + glutathione + NAD+
S-formylglutathione + NADH + H+
show the reaction diagram
formaldehyde + NAD+ + glutathione
S-formylglutathione + NADH
show the reaction diagram
-
multifunctional enzyme, ADH3 constitutes a key enzyme in the detoxification of endogenous and exogenous formaldehyde, formaldehyde is released during intracellular metabolism of endogenous compounds or xenobiotics, expression of ADH3 might thus fulfill a protective role against DNA damage resulting from formaldehyde sources, ADH3 itself catalyzes oxidative reactions which produce NADH, most importantly the oxidation of formaldehyde
-
-
?
S-(hydroxymethyl)glutathione + NAD(P)+
S-formylglutathione + NAD(P)H + H+
show the reaction diagram
-
multifunctional enzyme, large active site pocket of enzyme entails special substrate specificities: short-chain alcohols are poor substrates, while medium-chain alcohols and particularly the glutathione adducts S-hydroxymethylglutathioneand S-nitrosoglutathione are efficiently converted, universal presence and structural conservation imply that ADH3 performs essential housekeeping functions in living organisms
-
-
?
S-(hydroxymethyl)glutathione + NAD+
S-formylglutathione + NADH + H+
show the reaction diagram
S-nitrosoglutathione + NAD(P)H + H+
GSSG + ammonia + NAD(P)+
show the reaction diagram
S-nitrosoglutathione + NADH
? + NAD+
show the reaction diagram
S-nitrosoglutathione + NADH
GSH + NAD+ + NO
show the reaction diagram
-
the enzyme provides a defense mechanism against nitrosative stress, enzymatic pathway that modulates the bioactivity and toxicity of NO
-
-
?
S-nitrosoglutathione + NADH + H+
GSSG + ammonia + NAD+
show the reaction diagram
S-nitrosoglutathione + NADH + H+
GSSG + hydroxylamine + NAD+
show the reaction diagram
-
-
-
ir
S-nitrosoglutathione + NADH + H+
S-amino-L-glutathione + NAD+ + ?
show the reaction diagram
-
ADH3 can affect the transnitrosation equilibrium between S-nitrosoglutathione and S-nitrosated proteins, arguing for an important role in NO homeostasis
-
-
?
S-nitrosoglutathione + NADPH + H+
GSSG + ammonia + NADP+
show the reaction diagram
additional information
?
-