1.1.1.282: quinate/shikimate dehydrogenase [NAD(P)+]
This is an abbreviated version!
For detailed information about quinate/shikimate dehydrogenase [NAD(P)+], go to the full flat file.
Word Map on EC 1.1.1.282
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1.1.1.282
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3-dehydroquinate
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lignin
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corynebacterium
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nad+-dependent
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glutamicum
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cosubstrate
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drug development
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dehydrogenases
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agriculture
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synthesis
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medicine
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pharmacology
- 1.1.1.282
- 3-dehydroquinate
- lignin
-
corynebacterium
-
nad+-dependent
- glutamicum
-
cosubstrate
- drug development
- dehydrogenases
- agriculture
- synthesis
- medicine
- pharmacology
Reaction
Synonyms
cgl0424, cgR_0495, dehydroquinate dehydratase-shikimate dehydrogenase, More, NAD+ cofactor-specific QDH, NAD+-dependent enzyme quinate/shikimate dehydrogenase, NADP+ cofactor-specific QDH, NADP+-specific DHQD-QDH, PintaQDH, Poptr2, Poptr3, Poptr4, QDH, QSDH, qsuD, quinate dehydrogenase, quinate/shikimate 5-dehydrogenase, quinate/shikimate dehydrogenase, rifI, RifI2, SDH, SDH/QDH, sdhL, shikimate/quinate dehydrogenase, YdiB
ECTree
1.1.1.282 quinate/shikimate dehydrogenase [NAD(P)+]Advanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 1.1.1.282 - quinate/shikimate dehydrogenase [NAD(P)+]
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3-dehydroquinate + NADPH + H+
L-quinate + NADP+
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may be responsible for the synthesis of quinic acid from the intermediate compound of the shikimate pathway, dehydroquinic acid
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?
3-dehydroshikimate + NAD(P)H + H+
shikimate + NAD(P)+
YdiB catalyzes the reduction of 3-dehydroshikimate to shikimate as part of the shikimate pathway
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?
L-quinate + NAD+
3-dehydroquinate + NADH + H+
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r
L-quinate + NAD+
3-dehydroquinate + NADH + H+
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-
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r
L-quinate + NADP+
3-dehydroquinate + NADPH + H+
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r
quinate + NAD+
3-dehydroquinate + NADH + H+
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r
quinate + NADP+
3-dehydroquinate + NADPH + H+
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r
shikimate + NAD+
3-dehydroshikimate + NADH + H+
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r
shikimate + NAD+
3-dehydroshikimate + NADH + H+
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?
shikimate + NAD+
3-dehydroshikimate + NADH + H+
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r
shikimate + NAD+
3-dehydroshikimate + NADH + H+
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-
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?
shikimate + NAD+
3-dehydroshikimate + NADH + H+
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r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
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r
shikimate + NADP+
3-dehydroshikimate + NADPH + H+
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r
additional information
?
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the enzyme CglQSDH shows a substrate preference for quinate compared with shikimate both at the pH optimum and in a physiological pH range, which is a remarkable contrast to closely related SDH/QDH enzymes
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?
additional information
?
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the enzyme CglQSDH shows a substrate preference for quinate compared with shikimate both at the pH optimum and in a physiological pH range, which is a remarkable contrast to closely related SDH/QDH enzymes
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?
additional information
?
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the enzyme CglQSDH shows a substrate preference for quinate compared with shikimate both at the pH optimum and in a physiological pH range, which is a remarkable contrast to closely related SDH/QDH enzymes
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?
additional information
?
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YdiB may be involved in shikimate pathway or may be essential for growth of the organism with quinate as a sole carbon source
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?
additional information
?
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YdiB may be involved in shikimate pathway or may be essential for growth of the organism with quinate as a sole carbon source
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?
additional information
?
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the synthesis of quinate results from the reduction of 3-dehydroquinate by YdiB before its conversion to 3-dehydroshikimate. In Escherichia coli strain W3110.shik, YdiB, rather than AroE, catalyzes the oxidation of shikimate to 3-dehydroshikimate and the reduction of 3-dehydroquinate to quinate
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?
additional information
?
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the synthesis of quinate results from the reduction of 3-dehydroquinate by YdiB before its conversion to 3-dehydroshikimate. In Escherichia coli strain W3110.shik, YdiB, rather than AroE, catalyzes the oxidation of shikimate to 3-dehydroshikimate and the reduction of 3-dehydroquinate to quinate
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?
additional information
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catalyzes the first reaction in the inducible quinic acid catabolic pathway
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?
additional information
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the enzyme preferentially uses quinate as a substrate in vitro like a quinate dehydrogenase, EC 1.1.1.24, with only residual shikimate dehydrogenase, SDH, activity, cf. EC 1.1.1.25
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?
additional information
?
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initial enzyme of the hydroaromatic pathway
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?
additional information
?
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initial enzyme of the hydroaromatic pathway
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?
