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1.1.1.278: 3beta-hydroxy-5alpha-steroid dehydrogenase

This is an abbreviated version!
For detailed information about 3beta-hydroxy-5alpha-steroid dehydrogenase, go to the full flat file.

Reaction

3beta-hydroxy-5alpha-pregnane-20-one
+
NADP+
=
5alpha-pregnan-3,20-dione
+
NADPH
+
H+

Synonyms

3beta-HSD/isomerase, 3beta-hydroxy steroid dehydrogenase, 3beta-hydroxy-steroid dehydrogenase/DELTA5-DELTA4 isomerase, 3beta-hydroxysteroid oxidoreductase, 3beta-hydroxysteroid-5alpha-oxidoreductase, dehydrogenase, 3(17)beta-hydroxy steroid, More

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.278 3beta-hydroxy-5alpha-steroid dehydrogenase

Inhibitors

Inhibitors on EC 1.1.1.278 - 3beta-hydroxy-5alpha-steroid dehydrogenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-mercaptoethanol
-
activates at 1 mM, inhibitory at 10 mM
5alpha-pregnan-3,20-dione
-
-
ascorbate
-
-
L-cysteine
-
1 mM, together with 2-mercaptoethanl, up to 50% inhibition
NADPH
-
inhibitory at concentrations above 1 mM
progesterone
-
-
additional information
-
presence of C-7 allylic hydroxylation, in either epimeric form, inhibits 3beta-HSD/isomerase activity
-