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1.1.1.272: D-2-hydroxyacid dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about D-2-hydroxyacid dehydrogenase (NADP+), go to the full flat file.

Word Map on EC 1.1.1.272

Reaction

an (R)-2-hydroxycarboxylate
+
NADP+
=
a 2-oxocarboxylate
+
NADPH
+
H+

Synonyms

(R)-2-hydroxyacid dehydrogenase, (R)-sulfolactate dehydrogenase, (R)-sulfolactate:NAD(P)+ oxidoreductase, 2-D-hydroxyacid dehydrogenase, 2-HDH, 2HADH, D-2-hydroxyacid dehydrogenase, D-isomer specific 2-hydroxyacid dehydrogenase, D2-HDH, DDH, DDH_HALMT, HDH, L-2-hydroxyacid dehydrogenase, L-sulfolactate dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.272 D-2-hydroxyacid dehydrogenase (NADP+)

Systematic Name

Systematic Name on EC 1.1.1.272 - D-2-hydroxyacid dehydrogenase (NADP+)

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SYSTEMATIC NAME
IUBMB Comments
(R)-2-hydroxycarboxylate:NADP+ oxidoreductase
This enzyme, characterized from the halophilic archaeon Haloferax mediterranei and the mold Aspergillus oryzae, catalyses a stereospecific reduction of 2-oxocarboxylic acids into the corresponding D-2-hydroxycarboxylic acids. The enzyme prefers substrates with a main chain of 5 carbons (such as 4-methyl-2-oxopentanoate) to those with a shorter chain, and can use NADH with much lower efficiency. cf. EC 1.1.1.345, (D)-2-hydroxyacid dehydrogenase (NAD+).