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GDP-4-dehydro-6-deoxy-alpha-D-mannose + NADH + H+
GDP-beta-L-fucose + NAD+
GDP-4-dehydro-6-deoxy-alpha-D-mannose + NADPH + H+
GDP-beta-L-fucose + NADP+
GDP-4-dehydro-6-deoxy-D-mannose + NADPH
GDP-L-fucose + NADP+
GDP-4-dehydro-alpha-D-rhamnose + NADPH + H+
GDP-beta-L-fucose + NADP+
GDP-4-keto-6-deoxy-D-mannose + NADPH
GDP-6-deoxy-L-galactose + NADP+
GDP-4-keto-6-deoxy-D-mannose + NADPH + H+
GDP-L-fucose + NADP+
additional information
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fucosylation is regulated by complicated mechanisms that involve several factors: fucosyltransferases, GDP-fucose transporter, and GDP-fucose-synthetic enzymes, such as GDP-mannose 4,6-dehydratase, GDP-4-keto-6-deoxy-mannose-3,5-epimerase-4-reductase, and GDP-fucose pyrophosphorylase, fucose metabolism, overview
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GDP-4-dehydro-6-deoxy-alpha-D-mannose + NADH + H+
GDP-beta-L-fucose + NAD+
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GDP-4-dehydro-6-deoxy-alpha-D-mannose + NADH + H+
GDP-beta-L-fucose + NAD+
the enzyme synthesizes GDP-L-fucose from its substrate GDP-4-keto-6-deoxy-D-mannose. The reaction involves epimerization at both C-3 and C-5 followed by an NADPH-dependent reduction of the carbonyl at C-4
product identification by capillary electrophoresis, electro-spray ionization-mass spectrometry, and nuclear magnetic resonance spectroscopy
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GDP-4-dehydro-6-deoxy-alpha-D-mannose + NADH + H+
GDP-beta-L-fucose + NAD+
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GDP-4-dehydro-6-deoxy-alpha-D-mannose + NADPH + H+
GDP-beta-L-fucose + NADP+
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the enzyme synthesizes GDP-L-fucose from its substrate GDP-4-keto-6-deoxy-D-mannose. The reaction involves epimerization at both C-3 and C-5 followed by an NADPH-dependent reduction of the carbonyl at C-4
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GDP-4-dehydro-6-deoxy-alpha-D-mannose + NADPH + H+
GDP-beta-L-fucose + NADP+
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GDP-4-dehydro-6-deoxy-alpha-D-mannose + NADPH + H+
GDP-beta-L-fucose + NADP+
the enzyme synthesizes GDP-L-fucose from its substrate GDP-4-keto-6-deoxy-D-mannose. The reaction involves epimerization at both C-3 and C-5 followed by an NADPH-dependent reduction of the carbonyl at C-4
product identification by capillary electrophoresis, electro-spray ionization-mass spectrometry, and nuclear magnetic resonance spectroscopy
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GDP-4-dehydro-6-deoxy-D-mannose + NADPH
GDP-L-fucose + NADP+
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GDP-4-dehydro-6-deoxy-D-mannose + NADPH
GDP-L-fucose + NADP+
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the enzyme is crucial in the biosynthesis of GDP-L-fucose together with GDP-D-mannose-4,6-dehydratase, overview
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GDP-4-dehydro-6-deoxy-D-mannose + NADPH
GDP-L-fucose + NADP+
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GDP-4-dehydro-6-deoxy-D-mannose + NADPH
GDP-L-fucose + NADP+
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the enzyme is required for the formation of activated L-fucose
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GDP-4-dehydro-alpha-D-rhamnose + NADPH + H+
GDP-beta-L-fucose + NADP+
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GDP-4-dehydro-alpha-D-rhamnose + NADPH + H+
GDP-beta-L-fucose + NADP+
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GDP-4-dehydro-alpha-D-rhamnose + NADPH + H+
GDP-beta-L-fucose + NADP+
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GDP-4-dehydro-alpha-D-rhamnose + NADPH + H+
GDP-beta-L-fucose + NADP+
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GDP-4-keto-6-deoxy-D-mannose + NADPH
GDP-6-deoxy-L-galactose + NADP+
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bifunctional enzyme that exhibits epimerase and reductase activity: 3,5-epimerization to GDP-4-keto-6-deoxy-L-galactose and subsequent NADPH-dependent reduction to GDP-L-fucose
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GDP-4-keto-6-deoxy-D-mannose + NADPH
GDP-6-deoxy-L-galactose + NADP+
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catalyzes the last two steps in the de novo synthesis of L-fucose
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GDP-4-keto-6-deoxy-D-mannose + NADPH
GDP-6-deoxy-L-galactose + NADP+
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GDP-4-keto-6-deoxy-D-mannose + NADPH
GDP-6-deoxy-L-galactose + NADP+
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GDP-4-keto-6-deoxy-D-mannose + NADPH
GDP-6-deoxy-L-galactose + NADP+
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GDP-4-keto-6-deoxy-D-mannose + NADPH
GDP-6-deoxy-L-galactose + NADP+
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catalyzes the stereospecific hydride transfer of the ProS hydrogen from NADPH to carbon 4 of the mannose sugar
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GDP-4-keto-6-deoxy-D-mannose + NADPH
GDP-6-deoxy-L-galactose + NADP+
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enzyme also utilizes NADH but with lower affinity
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GDP-4-keto-6-deoxy-D-mannose + NADPH
GDP-6-deoxy-L-galactose + NADP+
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GDP-4-keto-6-deoxy-D-mannose + NADPH
GDP-6-deoxy-L-galactose + NADP+
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GDP-4-keto-6-deoxy-D-mannose + NADPH
GDP-6-deoxy-L-galactose + NADP+
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GDP-4-keto-6-deoxy-D-mannose + NADPH
GDP-6-deoxy-L-galactose + NADP+
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GDP-4-keto-6-deoxy-D-mannose + NADPH
GDP-6-deoxy-L-galactose + NADP+
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GDP-4-keto-6-deoxy-D-mannose + NADPH
GDP-6-deoxy-L-galactose + NADP+
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enzyme uses NADH as cofactor
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GDP-4-keto-6-deoxy-D-mannose + NADPH + H+
GDP-L-fucose + NADP+
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GDP-4-keto-6-deoxy-D-mannose + NADPH + H+
GDP-L-fucose + NADP+
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