1.1.1.27: L-lactate dehydrogenase This is an abbreviated version! For detailed information about L-lactate dehydrogenase, go to the full flat file .
Reaction
(S)-lactate +
NAD+ =
pyruvate +
NADH +
H+
Synonyms A4-LDH, AdhE, alpha-HBDH, alpha-hydroxybutyrate dehydrogenase, anaerobic lactate dehydrogenase, BbLDH, dehydrogenase, lactate, eLDHA, eLDHB, Epsilon crystallin, epsilon-crystallin, H4-L-lactate dehydrogenase, HBDH, heart LDH, Immunogenic protein p36, L(+)-nLDH, L-(+)-lactate dehydrogenase, L-lactate dehydrogenase, L-lactate dehydrogenase B, L-lactic acid dehydrogenase, L-lactic dehydrogenase, L-LDH, L-Ldh0845, L-nLDH, lactate dehydrogenase, lactate dehydrogenase 5, lactate dehydrogenase A, lactate dehydrogenase B, lactate dehydrogenase NAD-dependent, lactic acid dehydrogenase, lactic dehydrogenase, LctD, LDH, LDH-1, LDH-2, LDH-3, LDH-4, LDH-5, LDH-A, LDH-A4, LDH-m4, LDH1, LDH2, LdhA, LDHB, ldhL, LDHL1, LDHL2, LOX, LutACB, mL-LDH, mLDH, More, muscle LDH, NAD-dependent lactate dehydrogenase, NAD-lactate dehydrogenase, NGO0904, NGO0905, NGO0906, nitric oxideinducible l-lactate dehydrogenase, PfLDH, proteins, specific or class, anoxic stress response, p34, Sa-LDH-1, SMU.1115, SMU_1115, TeLdhL, Tsac_0416
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Natural Substrates Products on EC 1.1.1.27 - L-lactate dehydrogenase
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(S)-lactate + NAD(P)+
pyruvate + NAD(P)H + H+
(S)-lactate + NAD+
pyruvate + NADH + H+
L-lactate + NAD+
pyruvate + NADH
L-lactate + NAD+
pyruvate + NADH + H+
phenylpyruvate + NADH
phenyllactate + NAD+
pyruvate + NADH + H+
(S)-lactate + NAD+
pyruvate + NADH + H+
L-lactate + NAD+
additional information
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(S)-lactate + NAD(P)+
pyruvate + NAD(P)H + H+
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(S)-lactate + NAD(P)+
pyruvate + NAD(P)H + H+
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(S)-lactate + NAD(P)+
pyruvate + NAD(P)H + H+
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L-lactate transport and metabolism, regulation and localization of enzyme participating in the pathway, overview
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(S)-lactate + NAD+
pyruvate + NADH + H+
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(S)-lactate + NAD+
pyruvate + NADH + H+
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(S)-lactate + NAD+
pyruvate + NADH + H+
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(S)-lactate + NAD+
pyruvate + NADH + H+
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(S)-lactate + NAD+
pyruvate + NADH + H+
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(S)-lactate + NAD+
pyruvate + NADH + H+
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(S)-lactate + NAD+
pyruvate + NADH + H+
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(S)-lactate + NAD+
pyruvate + NADH + H+
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(S)-lactate + NAD+
pyruvate + NADH + H+
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(S)-lactate + NAD+
pyruvate + NADH + H+
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(S)-lactate + NAD+
pyruvate + NADH + H+
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(S)-lactate + NAD+
pyruvate + NADH + H+
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(S)-lactate + NAD+
pyruvate + NADH + H+
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(S)-lactate + NAD+
pyruvate + NADH + H+
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the astrocytic cell line CCF-STTG1 is able to consume lactate to generate ATP via oxidative phosphorylation, overview
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(S)-lactate + NAD+
pyruvate + NADH + H+
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since the mitochondrial metabolism of (S)-lactate results in synthesis and export of oxaloacetate, malate and citrate into the extramitochondrial phase, an anaplerotic role for the mitochondrial (S)-lactate metabolism is proposed
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(S)-lactate + NAD+
pyruvate + NADH + H+
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(S)-lactate + NAD+
pyruvate + NADH + H+
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(S)-lactate + NAD+
pyruvate + NADH + H+
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r
(S)-lactate + NAD+
pyruvate + NADH + H+
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(S)-lactate + NAD+
pyruvate + NADH + H+
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lactate oxidation does not occur unless pyruvate and especially NADH drop to low levels
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(S)-lactate + NAD+
pyruvate + NADH + H+
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lactate oxidation does not occur unless pyruvate and especially NADH drop to low levels
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r
(S)-lactate + NAD+
pyruvate + NADH + H+
LDH is a key enzyme in homolactic fermentation catalyzing the reduction of pyruvate to lactate with the concomitant oxidation of NADH, LDH and LDHB are involved in glycolysis
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(S)-lactate + NAD+
pyruvate + NADH + H+
LDH is a key enzyme in homolactic fermentation catalyzing the reduction of pyruvate to lactate with the concomitant oxidation of NADH, LDH and LDHB are involved in glycolysis
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(S)-lactate + NAD+
pyruvate + NADH + H+
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(S)-lactate + NAD+
pyruvate + NADH + H+
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(S)-lactate + NAD+
pyruvate + NADH + H+
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r
(S)-lactate + NAD+
pyruvate + NADH + H+
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involved in glycolysis
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(S)-lactate + NAD+
pyruvate + NADH + H+
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(S)-lactate + NAD+
pyruvate + NADH + H+
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mitochondrial metabolism of L-lactate plays a role in the response of potato to hypoxic stress
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(S)-lactate + NAD+
pyruvate + NADH + H+
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(S)-lactate + NAD+
pyruvate + NADH + H+
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(S)-lactate + NAD+
pyruvate + NADH + H+
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(S)-lactate + NAD+
pyruvate + NADH + H+
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(S)-lactate + NAD+
pyruvate + NADH + H+
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(S)-lactate + NAD+
pyruvate + NADH + H+
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L-lactate + NAD+
pyruvate + NADH
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L-lactate + NAD+
pyruvate + NADH
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the enzyme plays two important roles in heart metabolism, it catalyzes pyruvate reduction, mainly at the beginning of effort, or during hypoxia, and also catalyzes the oxidation of lactate released into the blood by other tissues, such as skeletal muscle, which would be used as substrate fuel by the heart mainly during steady-state exercise or during recuperation
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L-lactate + NAD+
pyruvate + NADH
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L-lactate + NAD+
pyruvate + NADH
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the enzyme plays two important roles in heart metabolism, it catalyzes pyruvate reduction, mainly at the beginning of effort, or during hypoxia, and also catalyzes the oxidation of lactate released into the blood by other tissues, such as skeletal muscle, which would be used as substrate fuel by the heart mainly during steady-state exercise or during recuperation
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L-lactate + NAD+
pyruvate + NADH + H+
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no activity with D-lactate
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L-lactate + NAD+
pyruvate + NADH + H+
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no activity with D-lactate
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L-lactate + NAD+
pyruvate + NADH + H+
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L-lactate + NAD+
pyruvate + NADH + H+
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the wild-type V583 strain converts glucose almost exclusively to L-lactate under anaerobic conditions
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L-lactate + NAD+
pyruvate + NADH + H+
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L-lactate + NAD+
pyruvate + NADH + H+
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L-lactate + NAD+
pyruvate + NADH + H+
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L-lactate + NAD+
pyruvate + NADH + H+
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L-lactate + NAD+
pyruvate + NADH + H+
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L-lactate + NAD+
pyruvate + NADH + H+
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phenylpyruvate + NADH
phenyllactate + NAD+
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phenylpyruvate + NADH
phenyllactate + NAD+
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pyruvate + NADH + H+
(S)-lactate + NAD+
LDH catalyzes the conversion of pyruvate to lactate with concomitant oxidation of NADH during the last step in anaerobic glycolysis
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pyruvate + NADH + H+
(S)-lactate + NAD+
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pyruvate + NADH + H+
(S)-lactate + NAD+
LDH catalyzes the conversion of pyruvate to lactate with concomitant oxidation of NADH during the last step in anaerobic glycolysis
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pyruvate + NADH + H+
(S)-lactate + NAD+
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pyruvate + NADH + H+
(S)-lactate + NAD+
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pyruvate + NADH + H+
(S)-lactate + NAD+
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inactivation of the lshL does not abolish the production of L-lactate, but the lactate final concentration decreases about 25% compared to the wild-type, suggesting the presence of at least a second L-Ldh
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pyruvate + NADH + H+
(S)-lactate + NAD+
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pyruvate + NADH + H+
(S)-lactate + NAD+
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pyruvate + NADH + H+
(S)-lactate + NAD+
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pyruvate + NADH + H+
(S)-lactate + NAD+
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pyruvate + NADH + H+
(S)-lactate + NAD+
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LdhB enzymes from type-I isolate NRRL 395 and type-II isolate 99-880 show reductive LDH activity, but no oxidative LDH activity, overview
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pyruvate + NADH + H+
(S)-lactate + NAD+
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the nitric oxide-inducible lactate dehydrogenase enables Staphylococcus aureus to resist innate immunity, L-lactate production allows Staphylococcus aureus to maintain redox homeostasis during nitrosative stress and is essential for virulence, regulation, overview
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pyruvate + NADH + H+
(S)-lactate + NAD+
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pyruvate + NADH + H+
(S)-lactate + NAD+
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pyruvate + NADH + H+
(S)-lactate + NAD+
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pyruvate + NADH + H+
(S)-lactate + NAD+
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D-glyceraldehyde-3-phosphate dehydrogenase and L-lactate dehydrogenase have a functional interaction that can affect NAD+/NADH metabolism and glycolysis in living cells
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pyruvate + NADH + H+
(S)-lactate + NAD+
LDH catalyzes the conversion of pyruvate to lactate with concomitant oxidation of NADH during the last step in anaerobic glycolysis
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pyruvate + NADH + H+
(S)-lactate + NAD+
terminal enzyme in aerobic glycolysis necessary for NAD+ regeneration
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pyruvate + NADH + H+
(S)-lactate + NAD+
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pyruvate + NADH + H+
(S)-lactate + NAD+
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pyruvate + NADH + H+
L-lactate + NAD+
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pyruvate + NADH + H+
L-lactate + NAD+
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enzyme activity increases in response to infection by black-rot fungus but decreases in response to cutting
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pyruvate + NADH + H+
L-lactate + NAD+
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key enzyme in anaerobic metabolism which converts pyruvate to lactate
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pyruvate + NADH + H+
L-lactate + NAD+
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pyruvate + NADH + H+
L-lactate + NAD+
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last step in anaerobic glycolysis
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pyruvate + NADH + H+
L-lactate + NAD+
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pyruvate + NADH + H+
L-lactate + NAD+
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additional information
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Bacillus subtilis fermentation pathways, overview
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Bacillus subtilis fermentation pathways, overview
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LDH is essential for continuous glycolysis necessary for accelerated tumor growth and increased LDH activity occurs already in grade 1 EC carcinomas
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the enzyme is unlikely to catalyze lactate oxidation at an appreciable rate under physiological conditions
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intracellular isozyme regulation in relation to pH, overview
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intracellular isozyme regulation in relation to pH, overview
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additional information
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intracellular isozyme regulation in relation to pH, overview
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additional information
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the enzyme is a component of the system regulating the cellular pH and/or controlling the concentration of reducing equivalents in the cytoplasm of leaf cells
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LDH is critically implicated in tumor growth
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LDH is critically implicated in tumor growth
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L-lactate dehydrogenase catalyzes the conversion of pyruvate to L-lactate using NADH as a cofactor
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additional information
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exogenous L-lactate enters mitochondria by a proton-compensated process, is converted to pyruvate, which is exported to the cytoplasm via a non-energy-competent L-lactate-pyruvate shuttle, overview
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