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1.1.1.268: 2-(R)-hydroxypropyl-CoM dehydrogenase

This is an abbreviated version!
For detailed information about 2-(R)-hydroxypropyl-CoM dehydrogenase, go to the full flat file.

Reaction

2-(R)-hydroxypropyl-CoM
+
NAD+
=
2-oxopropyl-CoM
+
NADH
+
H+

Synonyms

(R)-hydroxypropyl-coenzyme M dehydrogenase, (R)-hydroxypropylthioethanesulfonate dehydrogenase, 2-(2-(R)-hydroxypropylthio)ethanesulfonate dehydrogenase, 2-(R)-hydroxypropyl-coenzyme M dehydrogenase, R-HPCDH, xecD

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.268 2-(R)-hydroxypropyl-CoM dehydrogenase

KM Value

KM Value on EC 1.1.1.268 - 2-(R)-hydroxypropyl-CoM dehydrogenase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
326
(2R)-2-butanol
recombinant enzyme, pH and temperature not specified in the publication
-
2.64
(2R)-2-heptanol
recombinant enzyme, pH and temperature not specified in the publication
-
4.6
(2R)-2-hexanol
recombinant enzyme, pH and temperature not specified in the publication
-
0.102
(2R)-2-hydroxypropyl-CoM
recombinant enzyme, pH and temperature not specified in the publication
-
1.08
(2R)-2-octanol
recombinant enzyme, pH and temperature not specified in the publication
-
20
(2R)-2-pentanol
recombinant enzyme, pH and temperature not specified in the publication
-
315
(2S)-2-butanol
recombinant enzyme, pH and temperature not specified in the publication
-
0.1
(2S)-2-hydroxypropyl-CoM
recombinant enzyme, pH and temperature not specified in the publication
153
(2S)-2-pentanol
recombinant enzyme, pH and temperature not specified in the publication
-
220 - 328
(R)-2-butanol
2.64
(R)-2-heptanol
-
pH 7.5, 30°C
4.6
(R)-2-hexanol
-
pH 7.5, 30°C
1.08
(R)-2-octanol
-
pH 7.5, 30°C
20
(R)-2-pentanol
-
pH 7.5, 30°C
315 - 350
(S)-2-butanol
153
(S)-2-pentanol
-
pH 7.5, 30°C
0.75 - 0.96
2-(2-hydroxyethylthio)ethanesulfonate
0.092 - 0.44
2-(2-ketopropylthio)ethanesulfonate
0.096 - 0.124
2-(R)-hydroxypropyl-CoM
0.22
2-(S)-hydroxypropyl-CoM
pH 7.5, 30°C
2 - 84
2-butanone
0.068
2-oxopropyl-CoM
pH 7.5, 30°C
1726
2-propanol
0.102
2-[(R)-2-hydroxypropylthio]ethanesulfonate
-
pH 7.5, 30°C
0.1
2-[(S)-2-hydroxypropylthio]ethanesulfonate
-
pH 7.5, 30°C
additional information
additional information
steady-state kinetics, comparison of steady-state kinetics with wild-type an d mutant enzymes, overview
-