1.1.1.267: 1-deoxy-D-xylulose-5-phosphate reductoisomerase

This is an abbreviated version!
For detailed information about 1-deoxy-D-xylulose-5-phosphate reductoisomerase, go to the full flat file.

Word Map on EC 1.1.1.267

1.1.1.267

isoprenoids

fosmidomycin

plasmodium

falciparum

antimalarial

terpenoids

isopentenyl

non-mevalonate

mevalonate

isoprene

phosphonate

drug development

dimethylallyl

mevalonate-independent

medicine

biotechnology

Reaction

2-C-methyl-D-erythritol 4-phosphate

+

NADP⁺

=

1-deoxy-D-xylulose 5-phosphate

+

NADPH

+

H+

Synonyms

1-deoxy-D-xylulose 5-phosphate isomeroreductase, 1-deoxy-D-xylulose 5-phosphate reductoisomerase, 1-deoxy-D-xylulose-5-phosphate, 1-deoxy-D-xylulose-5-phosphate reductoisomerase, 1-deoxy-D-xylulose-5-phosphate synthase, 1-deoxyxylulose 5-phosphate reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C-methyl-D-erythritol 4-phosphate synthase, 2C-methyl-D-erythritol 4-phosphate synthase, 2C-methyl-D-erythritol-4-phosphate synthase, AaDXR, CaDXR, deoxyxylulose 5-phosphate reductoisomerase, deoxyxylulosephosphate reductoisomerase, DOXP reductoisomerase, DOXP-reductoisomerase, DXP reductoisomerase, DXP-reductoisomerase, DXR, DXR1, DzDXR, EcDXR, FtIspC, IspC, MEP synthase, meps, methylerythritol phosphate synthase, MtbIspC, MtDXR, Os01g01710, OsDXR, PdDXR, PfDXR, PtDXR, Rv2870c, SaDXR, VvDxr, YpIspC

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.267 1-deoxy-D-xylulose-5-phosphate reductoisomerase

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Results	in table
7	Activating Compound
35608	AA Sequence
29	Application
1	CAS Registry Number
58	Cloned(Commentary)
106	Cofactor
16	Crystallization (Commentary)
10	Expression
64	General Information
162	IC50 Value
385	Inhibitors
14	kcat/KM [mM/s]
64	Ki Value [mM]
85	KM Value [mM]
21	Localization
76	Metals/Ions
24	Molecular Weight [Da]
66	Natural Substrates/ Products (Substrates)
540	Organism
7	Pathway
136	PDB ID
30	pH Optimum
1	pH Range
1	pH Stability
6	pI Value
4	Posttranslational Modification
47	Protein Variants
28	Purification (Commentary)
14	Reaction
3	Reaction Type
134	Reference
92	Source Tissue
8	Specific Activity [micromol/min/mg]
8	Storage Stability
141	Substrates and Products (Substrate)
29	Subunits
190	Synonyms
1	Systematic Name
29	Temperature Optimum [°C]
2	Temperature Range [°C]
4	Temperature Stability [°C]
36	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 1.1.1.267 - 1-deoxy-D-xylulose-5-phosphate reductoisomerase

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0.003

(2-[[hydroxy(methyl)carbamoyl]oxy]ethyl)phosphonic acid

Escherichia coli

above, pH and temperature not specified in the publication

-

0.31

(2R,3R)-2,3,4-trihydroxybutyl dihydrogen phosphate

Escherichia coli

-

IC50: 0.310 mM

5

(2R,3R)-4-amino-2,3-dihydroxybutyl dihydrogen phosphate

Escherichia coli

-

very weak inhibitor, IC50: 5 mM, above

5

(2R,3S)-2,3-dihydroxy-4-(hydroxyamino)-4-oxobutyl dihydrogen phosphate

Escherichia coli

-

very weak inhibitor, IC50: 5 mM, above

0.253

(2R,3S)-4-amino-2,3-dihydroxy-4-oxobutyl dihydrogen phosphate

Escherichia coli

-

IC50: 0.253 mM

0.551

(2S,3R)-2,3-dihydroxy-4-phosphonooxybutyric acid

Escherichia coli

-

IC50: 0.551 mM

1.024

(2S,3R)-methyl 2,3-dihydroxy-4-phosphonooxybutyrate

Escherichia coli

-

IC50: 1.024 mM

0.0013

(3-(hydroxy[(pentafluorophenyl)carbonyl]amino)propyl)phosphonic acid

Escherichia coli

pH 7.5, 30°C

0.0074

(3-(N-hydroxyacetamido)-1-phenyl)propylphosphonic acid

Mycobacterium tuberculosis

pH 7,5, 22°C

0.0054

(3-[hydroxy(5-oxohexanoyl)amino]propyl)phosphonic acid

Escherichia coli

pH 7.5, 30°C

0.0051

(3-[hydroxy(6-phenylhexanoyl)amino]propyl)phosphonic acid

Escherichia coli

pH 7.5, 30°C

0.0056

(3-[hydroxy(hexadecanoyl)amino]propyl)phosphonic acid

Escherichia coli

pH 7.5, 30°C

0.03

(3S,4R)-3,4-dihydroxy-4-methyl-5-oxohexylphosphonic acid

Escherichia coli

-

-

1

(4-hydrazinyl-4-oxobutyl)phosphonic acid

Escherichia coli

pH and temperature not specified in the publication

-

0.000087 - 0.00036

([[acetyl(hydroxy)amino]methoxy]methyl)phosphonic acid

show

-

0.0011 - 0.0049

([[formyl(hydroxy)amino]methoxy]methyl)phosphonic acid

show

-

0.0014

1-hydroxy-5-phenylpyridin-2(1H)-one

Escherichia coli

pH and temperature not specified in the publication

0.0038 - 0.0061

2-[(5Z)-5-(3,4-dihydroxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]-N-hydroxyacetamide

show

0.000077 - 0.000279

2-[acetyl(hydroxy)amino]ethyl phosphate

show

-

0.000077 - 0.000279

2-[acetyl(methyl)amino]ethyl phosphate

show

-

0.000342 - 0.0021

2-[formyl(hydroxy)amino]ethyl phosphate

show

-

0.00312 - 0.125

3,3-dimethyl-11-phenyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one

show

-

0.0093 - 0.02

3-(hydroxy([(2-phenylbutanoyl)amino]acetyl)amino)propylphosphonic acid

show

0.0096 - 0.012

3-(hydroxy([(3-methylbutanoyl)amino]acetyl)amino)propylphosphonic acid

show

0.0004 - 0.001

3-(hydroxy([(4-phenoxybutanoyl)amino]acetyl)amino)propylphosphonic acid

show

0.019 - 0.02

3-(hydroxy([(4-phenylbutanoyl)amino]acetyl)amino)propylphosphonic acid

show

0.0026 - 0.0092

3-(hydroxyamino)-3-oxopropyl phosphate

show

-

0.0007

3-(N-hydroxyacetamido)-1-(3,4-dichlorophenyl)propylphosphonic acid

Mycobacterium tuberculosis

pH 7,5, 22°C

0.0056

3-(N-hydroxyformamido)-1-(2-bromophenyl)propylphosphonic acid

Mycobacterium tuberculosis

pH 7,5, 22°C

0.00015

3-(N-hydroxyformamido)-1-(3,4-dichlorophenyl)propylphosphonic acid

Mycobacterium tuberculosis

pH 7,5, 22°C

0.03

3-([(1H-indol-3-yl)acetyl]amino)propylphosphonic acid

Escherichia coli

-

-

0.03

3-([2-(methoxycarbonyl)benzoyl]amino)propylphosphonic acid

Escherichia coli

-

-

0.03

3-([3-(1H-indol-3-yl)propanoyl]amino)propylphosphonic acid

Escherichia coli

-

-

0.03

3-([4-(1H-indol-3-yl)butanoyl]amino)propylphosphonic acid

Escherichia coli

-

-

0.012 - 0.014

3-[(([(3,4-dimethoxyphenyl)acetyl]amino)acetyl)(hydroxy)amino]propylphosphonic acid

show

0.03

3-[(2-hydroxybenzoyl)amino]propylphosphonic acid

Escherichia coli

-

-

0.03

3-[(3,4-diethoxybenzoyl)amino]propylphosphonic acid

Escherichia coli

-

-

0.03

3-[(3,4-dimethoxybenzoyl)amino]propylphosphonic acid

Escherichia coli

-

-

0.03

3-[(4-methylpentanoyl)amino]propylphosphonic acid

Escherichia coli

-

-

0.03

3-[(4-phenoxybenzoyl)amino]propylphosphonic acid

Escherichia coli

-

-

0.0033 - 0.0071

3-[([(cyclopropylcarbonyl)amino]acetyl)(hydroxy)amino]propylphosphonic acid

show

0.0029 - 0.0051

3-[hydroxy(([3-(trifluoromethoxy)benzoyl]amino)acetyl)amino]propylphosphonic acid

show

0.0066 - 0.017

3-[hydroxy(([4-(1H-indol-3-yl)butanoyl]amino)acetyl)amino]propylphosphonic acid

show

0.000046 - 0.000233

3-[hydroxy(methyl)amino]-3-oxopropyl phosphate

show

-

0.1

4-(1-(4-hydroxy-2-oxo-2H-chromen-3-yl)-2-methylpropyl)-5-methyl-2-(4-nitrophenyl)-1,2-dihydro-3H-pyrazol-3-one

Plasmodium falciparum

pH 7.5, 22°C

-

0.0224

4-benzylbenzene-1,2-diol

Escherichia coli

pH and temperature not specified in the publication

0.025

5-[hydroxy(methyl)amino]-5-oxopentanoic acid

Escherichia coli

pH and temperature not specified in the publication

-

0.1

diethyl (1-(3,4-dichlorophenyl)-3-(N-hydroxyacetamido)propyl)phosphonate

Mycobacterium tuberculosis

above, pH 7,5, 22°C

0.1

diethyl (1-(3,4-dichlorophenyl)-3-(N-hydroxyformamido)propyl)phosphonate

Mycobacterium tuberculosis

above, pH 7,5, 22°C

0.408

diethyl (2-[[(furan-2-yl)methyl]amino]-2-oxoethyl)phosphonate

Escherichia coli

pH and temperature not specified in the publication

-

0.73

diethyl [2-oxo-2-[(1,3-thiazol-2-yl)amino]ethyl]phosphonate

Escherichia coli

pH and temperature not specified in the publication

-

0.472

diethyl [2-oxo-2-[(pyridin-2-yl)amino]ethyl]phosphonate

Escherichia coli

pH and temperature not specified in the publication

-

0.2098

epigallocatechin gallate

Escherichia coli

pH 7.0, 37°C, recombinant enzyme

0.04 - 0.125

ethyl 2-(2-ethoxy-2-oxoethyl)-2,5-dihydro-1H-benzo[b][1,4]diazepine-3-carboxylate

show

-

0.038

ethyl hydrogen [1-(3,4-dichlorophenyl)-3-[formyl(hydroxy)amino]propyl]phosphonate

Mycobacterium tuberculosis

pH 7,5, 22°C

0.022

ethyl hydrogen [3-[acetyl(hydroxy)amino]-1-(3,4-dichlorophenyl)propyl]phosphonate

Mycobacterium tuberculosis

pH 7,5, 22°C

0.000342 - 0.0021

fosfoxacin

show

0.000008 - 107

fosmidomycin

show

0.000018 - 0.00032

FR-900098

show

0.000004 - 0.118

FR900098

show

0.0275

gallocatechin gallate

Escherichia coli

pH 7.0, 37°C, recombinant enzyme

0.0000045 - 0.0000092

[(3,4-dichlorophenyl)([2-[hydroxy(methyl)amino]-2-oxoethyl]sulfanyl)methyl]phosphonic acid

show

-

0.00084

[(5-phenylpyridin-2-yl)methyl]phosphonic acid

Escherichia coli

pH and temperature not specified in the publication

0.0031 - 0.0044

[(5Z)-5-(3,4-dihydroxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid

show

0.0159

[(quinolin-2-yl)methyl]phosphonic acid

Escherichia coli

pH and temperature not specified in the publication

-

0.0447

[1,1'-biphenyl]-3,4-diol

Escherichia coli

pH and temperature not specified in the publication

-

0.000028 - 0.000059

[1-(3,4-dichlorophenyl)-3-[formyl(hydroxy)amino]propyl]phosphonic acid

show

0.053

[2-(1-hydroxy-6-oxo-1,6-dihydropyridin-2-yl)ethyl]phosphonic acid

Mycobacterium tuberculosis

pH and temperature not specified in the publication

-

1.2

[2-(2,3-dihydroxyphenyl)ethyl]phosphonic acid

Escherichia coli

pH and temperature not specified in the publication

-

0.041

[2-(3-hydroxy-4-methylphenyl)ethyl]phosphonic acid

Mycobacterium tuberculosis

pH and temperature not specified in the publication

-

0.003

[2-[(hydroxycarbamoyl)oxy]ethyl]phosphonic acid

Escherichia coli

above, pH and temperature not specified in the publication

-

0.0021

[3-(acetyl(hydroxy)amino)propyl]phosphonic acid 3-methylbutyl ester

Escherichia coli

at 0.03 mM

0.0024

[3-(acetyl(hydroxy)amino)propyl]phosphonic acid mono(2-naphthalen-1-yl-ethyl) ester

Escherichia coli

at 0.03 mM

0.0016

[3-(acetyl(hydroxy)amino)propyl]phosphonic acid mono(2-naphthalen-2-yl-ethyl) ester

Escherichia coli

at 0.03 mM

0.0039

[3-(acetyl(hydroxy)amino)propyl]phosphonic acid mono-n-butyl ester

Escherichia coli

at 0.03 mM

0.016

[3-(acetyl(hydroxy)amino)propyl]phosphonic acid mono-n-propyl ester

Escherichia coli

at 0.03 mM

0.05

[3-(acetyl(hydroxy)amino)propyl]phosphonic acid monomethyl ester

Escherichia coli

at 0.03 mM

0.00049

[3-(acetyl(hydroxy)amino)propyl]phosphonic acid monophenethyl ester

Escherichia coli

at 0.03 mM

0.023

[3-(acetyl(hydroxy)amino)propyl]phosphonic monoethyl ester

Escherichia coli

at 0.03 mM

0.21

[3-[acetyl(hydroxy)amino]-1-(2-bromophenyl)propyl]phosphonic acid

Mycobacterium tuberculosis

pH 7,5, 22°C

0.205

[3-[acetyl(hydroxy)amino]-1-(2-methylphenyl)propyl]phosphonic acid

Mycobacterium tuberculosis

pH 7,5, 22°C

0.00009 - 0.000119

[3-[acetyl(hydroxy)amino]-1-(3,4-dichlorophenyl)propyl]phosphonic acid

show

0.00031 - 0.00044

[3-[acetyl(hydroxy)amino]-1-(pyridin-3-yl)propyl]phosphonic acid

show

0.00046 - 0.00063

[3-[acetyl(hydroxy)amino]-1-(pyridin-4-yl)propyl]phosphonic acid

show

0.0017 - 0.0035

[3-[acetyl(hydroxy)amino]-1-phenylpropyl]phosphonic acid

show

0.15

[3-[acetyl(hydroxy)amino]-1-[2-(2-hydroxyethyl)phenyl]propyl]phosphonic acid

Mycobacterium tuberculosis

pH 7,5, 22°C

0.465

[3-[acetyl(hydroxy)amino]-1-[2-(hydroxymethyl)phenyl]propyl]phosphonic acid

Mycobacterium tuberculosis

pH 7,5, 22°C

0.00018 - 0.00034

[3-[formyl(hydroxy)amino]-1-(pyridin-3-yl)propyl]phosphonic acid

show

0.00017 - 0.00018

[3-[formyl(hydroxy)amino]-1-(pyridin-4-yl)propyl]phosphonic acid

show

0.0178

[3-[hydroxy(3-phenylpropanoyl)amino]propyl]phosphonic acid

Mycobacterium tuberculosis

-

pH not specified in the publication, temperature not specified in the publication

0.064

[4-(2-acetylanilino)-4-oxobutyl]phosphonic acid, [4-(2-fluoroanilino)-4-oxobutyl]phosphonic acid

Plasmodium falciparum

above, pH and temperature not specified in the publication

-

0.00017 - 0.00148

[4-(hydroxyamino)-4-oxobutyl]phosphonic acid

show

0.93

[4-(methoxyamino)-4-oxobutyl]phosphonic acid

Escherichia coli

pH and temperature not specified in the publication

-

0.064

[4-[2-(methanesulfonyl)anilino]-4-oxobutyl]phosphonic acid

Plasmodium falciparum

above, pH and temperature not specified in the publication

-

0.000048 - 0.00041

[4-[hydroxy(methyl)amino]-4-oxobutyl]phosphonic acid

show

-

3.8

[4-[methoxy(methyl)amino]-4-oxobutyl]phosphonic acid

Escherichia coli

pH and temperature not specified in the publication

-

0.004

[[(isoquinolin-1-yl)amino]methylene]bis(phosphonic acid)

Escherichia coli

pH and temperature not specified in the publication

-

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Release 2023.1 (January 2023)