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1.1.1.265: 3-methylbutanal reductase

This is an abbreviated version!
For detailed information about 3-methylbutanal reductase, go to the full flat file.

Word Map on EC 1.1.1.265

Reaction

3-Methylbutanol
+
NAD(P)+
=
3-Methylbutanal
 +
NAD(P)H
 +
H+

Synonyms

3-methylbutyraldehyde reductase, aldehyde reductase, bcADH, branched-chain alcohol dehydrogenase, Gre2, GRE2 gene product, Gre2p, isoamylaldehyde reductase, isopentanal reductase, isovaleral reductase, isovaleraldehyde reductase, More, protein YIM1, YIM1, YMR152W, Ymr152wp, YOL151W, YOL151w gene product

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.265 3-methylbutanal reductase

Engineering

Engineering on EC 1.1.1.265 - 3-methylbutanal reductase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
F132A
about 200% of wild-type activity
F85A
less than 0.5% of wild-type activity
L169L
complete loss of activity
S127A
complete loss of activity
V162A
about 150% of wild-type activity
V198A
about 1.5% of wild-type activity
Y128A
about 1.5% of wild-type activity
Y128F
activity similar to wild-type
Y165A
complete loss of activity
Y165F
complete loss of activity
Y198F
about 75% of wild-type activity
additional information
-
creation of a knockout mutant that forms large, invasive filaments