1.1.1.262: 4-hydroxythreonine-4-phosphate dehydrogenase

This is an abbreviated version!
For detailed information about 4-hydroxythreonine-4-phosphate dehydrogenase, go to the full flat file.

Reaction

Synonyms

4-(phosphohydroxy)-L-threonine dehydrogenase, L-threonine 4-phosphate dehydrogenase, NAD-dependent threonine 4-phosphate dehydrogenase, PdxA

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.262 4-hydroxythreonine-4-phosphate dehydrogenase

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Results	in table
20458	AA Sequence
1	CAS Registry Number
4	Cloned(Commentary)
3	Cofactor
1	Crystallization (Commentary)
1	Inhibitors
2	Metals/Ions
5	Natural Substrates/ Products (Substrates)
5	Organism
5	Pathway
25	PDB ID
1	pH Optimum
4	Purification (Commentary)
3	Reaction
3	Reaction Type
5	Reference
3	Source Tissue
8	Substrates and Products (Substrate)
2	Subunits
6	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 1.1.1.262 - 4-hydroxythreonine-4-phosphate dehydrogenase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

2-amino-3-oxo-4-phosphonooxybutyrate + H2O

3-amino-1-hydroxyacetone 1-phosphate + CO2

Escherichia coli

P19624

step 2 of the overall reaction

656172

i.e. AHAP

-

?

4-(phosphohydroxy)-L-threonine + NAD+

2-amino-3-oxo-4-phosphohydroxybutyrate + NADH

2 entries

4-(phosphohydroxy)-L-threonine + NAD+

3-phosphohydroxy-1aminoacetone + CO2 + NADH + H+

Escherichia coli

-

involved in pyridoxal 5'-phosphate formation

207963

further condensation with 1-deoxy-D-xylulose-5-phosphate to form pyridoxal 5'-phosphate

207963

r

4-(phosphonooxy)threonine + NAD(P)+

2-amino-3-oxo-4-phosphonooxybutyrate + NAD(P)H

2 entries

4-(phosphonooxy)threonine + NAD(P)+

3-amino-1-hydroxyacetone 1-phosphate + CO2 + NAD(P)H

2 entries

4-(phosphohydroxy)-L-threonine + NAD+

2-amino-3-oxo-4-phosphohydroxybutyrate + NADH

Escherichia coli

-

involved in pyridoxal 5'-phosphate formation

207962

further condensation with 1-deoxy-D-xylulose-5-phosphate to form pyridoxal 5'-phosphate

207962

r

4-(phosphohydroxy)-L-threonine + NAD+

2-amino-3-oxo-4-phosphohydroxybutyrate + NADH

Escherichia coli

-

involved in pyridoxal 5'-phosphate formation

207964

undergoes decarboxylation either catalysed by the enzyme or after release, further formation of pyridoxal 5'-phosphate catalysed by PdxJ protein

207964

r

4-(phosphonooxy)threonine + NAD(P)+

2-amino-3-oxo-4-phosphonooxybutyrate + NAD(P)H

Escherichia coli

P19624

fourth step of the pyridoxal 5'-phosphate biosynthesis

656172

-

-

?

4-(phosphonooxy)threonine + NAD(P)+

2-amino-3-oxo-4-phosphonooxybutyrate + NAD(P)H

Escherichia coli

P19624

i.e. 4-hydroxy-L-threonine phosphate or HTP, enzyme strictly requires the phosphate ester form of the substrate, interaction between enzyme and substrate via phosphate group, step 1 of the overall reaction

656172

reaction intermediate

-

?

4-(phosphonooxy)threonine + NAD(P)+

3-amino-1-hydroxyacetone 1-phosphate + CO2 + NAD(P)H

Escherichia coli

-

involved in the biosynthesis of vitamin B6

654972

-

-

?

4-(phosphonooxy)threonine + NAD(P)+

3-amino-1-hydroxyacetone 1-phosphate + CO2 + NAD(P)H

Escherichia coli

-

i.e. 4-hydroxy-L-threonine-4-phosphate, HTP

654972

i.e. AHAB, primary product of the reaction, no formation of 2-amino-3-oxo-4-phosphonooxybutyrate as intermediate is detected, identification by electrospray ionization mass spectrometry

-

?