1.1.1.26: glyoxylate reductase

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For detailed information about glyoxylate reductase, go to the full flat file.

Reaction

Synonyms

GHPR, glycerate dehydrogenase, glycolate oxidase, glyoxylate reductase isoform 1, glyoxylate reductase/hydroxypyruvate reductase, glyoxylate/hydroxypyruvate reductase, glyoxylic acid reductase, GLYR1, GLYR2, GRHPR, GxrA, HPR1, NADH-dependent glyoxylate reductase, NADH-glyoxylate reductase, reductase, glyoxylate, SSO3187, succinic semialdehyde/glyoxylate reductase

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.26 glyoxylate reductase

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Results	in table
1251	AA Sequence
2	Application
1	CAS Registry Number
6	Cloned(Commentary)
42	Cofactor
1	Crystallization (Commentary)
156	Disease/ Diagnostics
2	Expression
10	General Information
20	Inhibitors
31	KM Value [mM]
19	Localization
14	Molecular Weight [Da]
29	Natural Substrates/ Products (Substrates)
36	Organism
8	Pathway
12	PDB ID
11	pH Optimum
6	pH Range
8	Protein Variants
10	Purification (Commentary)
2	Reaction
2	Reaction Type
34	Reference
38	Source Tissue
22	Specific Activity [micromol/min/mg]
2	Storage Stability
67	Substrates and Products (Substrate)
12	Subunits
26	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]
19	Turnover Number [1/s]

Engineering

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Engineering on EC 1.1.1.26 - glyoxylate reductase

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

T335A

Arabidopsis thaliana

Q9C9W5

nonphosphorylatable variant

762165

T335D

Arabidopsis thaliana

Q9C9W5

phosphomimetic variant, exhibits reduced NADH-dependent hydroxypyruvate reductase activity while showing improved NADPH-dependent activity

762165

G165D

Homo sapiens

-

mutation identified in patient with primary hyperoxaluria type 2, about 1.5% residual enzymic activity, enzyme is unstable upon purification

655702

R302C

Homo sapiens

-

mutation identified in patient with primary hyperoxaluria type 2, about 5.6% residual enzymic activity, enzyme is unstable upon purification

655702

additional information

4 entries

additional information

Arabidopsis thaliana

-

complementation of SSADH-deficient yeast with Arabidopsis thaliana GLYR1, the yeast then grows on 20 mM GABA as the sole nitrogen source and contains elevated levels of 4-hydroxybutyrate

696125

additional information

Homo sapiens

-

identification of point mutations and minor deletions resulting in primary hyperoxaluria type 2

655702

additional information

Hordeum vulgare

-

mutant lacking cytosolic hydroxypyruvate-metabolizing activity (HPR-1)

286418

additional information

Paracoccus sp.

-

construction of a E141N/Q313E mutant formate dehydrogenase which gains glyoxylate reductase activity improved through enhancement of the hydrogen transfer step in the catalytic process, while the replacement induces no marked activity toward other 2-koxoacid substrates, and diminishes the enzyme's activity as to formate oxidation, substrate specificity and kinetic switch of the mutant, overview

684838