1.1.1.248: salutaridine reductase (NADPH)
This is an abbreviated version!
For detailed information about salutaridine reductase (NADPH), go to the full flat file.
Reaction
Synonyms
More, PsSAR, reductase, salutaridine 7-, SalR, salutaridine 7-reductase, salutaridine reductase
ECTree
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Substrates Products
Substrates Products on EC 1.1.1.248 - salutaridine reductase (NADPH)
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REACTION DIAGRAM
salutaridine + NAD(P)H + H+
(7S)-salutaridinol + NAD(P)+
NADPH is the highly preferred cofactor, the enzyme shows high substrate specificity, no activity with tropinone, (2)-menthone, codeinone and dehydroreticulinium ion, or nordehydroreticuline. Asp152, Ser180, Tyr236, and Lys240 are involved in the proton transfer system for the reduction of salutaridine, substrate-active site binding structure, overview
the enzyme produces only the (7S)-salutaridinol stereoisomer as product, not the stereoisomer 7-epi-salutaridinol
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r
(7S)-salutaridinol + NADP+
Papaver arenarium
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moderate levels of SalR expression in Papaver arenarium
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?
salutaridine + NADPH + H+
(7S)-salutaridinol + NADP+
moderate levels of SalR expression in Papaver bracteatum
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?
salutaridine + NADPH + H+
(7S)-salutaridinol + NADP+
a step in the unique biosynthesis of morphine via codeine, overview
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r
salutaridine + NADPH + H+
(7S)-salutaridinol + NADP+
NADPH-dependent reduction of the 7-keto group
no formation of 7-epi-salutaridinol
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r
salutaridine + NADPH + H+
(7S)-salutaridinol + NADP+
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high levels of SalR expression in all Papaver somniferum varieties
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?
salutaridine + NADPH + H+
(7S)-salutaridinol + NADP+
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interaction between SalR and SalAT in morphine biosynthesis
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?
salutaridine + NADPH + H+
(7S)-salutaridinol + NADP+
a step in the unique biosynthesis of morphine via codeine, overview
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r
salutaridine + NADPH + H+
(7S)-salutaridinol + NADP+
NADPH-dependent reduction of the 7-keto group
no formation of 7-epi-salutaridinol
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r
salutaridine + NADPH + H+
salutaridinol + NADP+
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formation of salutaridinol, a precursor for the synthesis of morphine and related opium alkaloids
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?
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the enzyme is involved in the biosynthesis of morphine
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?
additional information
?
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the enzyme is involved in the biosynthesis of morphine
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additional information
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interaction of benzylisoquinoline alkaloids with enzymes, modeling, overview
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additional information
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interaction of benzylisoquinoline alkaloids with enzymes, modeling, overview
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additional information
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occurrence of active SalR homologue in Papaver pilosum, although it does not produce salutaridine or any other promorphinan alkaloid
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additional information
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Papaver pyrenaicum
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occurrence of active SalR homologue in Papaver pyrenaicum, although it does not produce salutaridine or any other promorphinan alkaloid
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?
additional information
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alkaloid composition of the organism
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additional information
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no reduction of 1,2-nordehydroreticuline, 1,2-dehydroreticulinium ion, codeinone, tropinone, or (-)-menthone, no oxidation of (R)-norreticuline, (R)-reticuline, codeine, tropine, or (+)-neomenthol
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?
additional information
?
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no reduction of 1,2-nordehydroreticuline, 1,2-dehydroreticulinium ion, codeinone, tropinone, or (-)-menthone, no oxidation of (R)-norreticuline, (R)-reticuline, codeine, tropine, or (+)-neomenthol
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?
additional information
?
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alkaloid composition of the organism
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?
additional information
?
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no reduction of 1,2-nordehydroreticuline, 1,2-dehydroreticulinium ion, codeinone, tropinone, or (-)-menthone, no oxidation of (R)-norreticuline, (R)-reticuline, codeine, tropine, or (+)-neomenthol
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?