1.1.1.23: histidinol dehydrogenase

This is an abbreviated version!
For detailed information about histidinol dehydrogenase, go to the full flat file.

Reaction

+ 2 NAD⁺ +

+ 2 NADH + 2 H+

Synonyms

11412251, BN980_GECA03s06082g, BsHDH, GcHDH, HDH, HIS4 protein, HisD, histidinol dehydrogenase, HLDase, L-histidinol dehydrogenase

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.23 histidinol dehydrogenase

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Results	in table
1	Activating Compound
37903	AA Sequence
14	Application
1	CAS Registry Number
12	Cloned(Commentary)
46	Cofactor
6	Crystallization (Commentary)
51	General Information
95	IC50 Value
145	Inhibitors
6	kcat/KM [mM/s]
5	Ki Value [mM]
38	KM Value [mM]
6	Localization
79	Metals/Ions
23	Molecular Weight [Da]
86	Natural Substrates/ Products (Substrates)
66	Organism
5	Pathway
31	PDB ID
16	pH Optimum
2	pH Range
1	pH Stability
7	Protein Variants
13	Purification (Commentary)
20	Reaction
1	Reaction Type
59	Reference
8	Source Tissue
23	Specific Activity [micromol/min/mg]
3	Storage Stability
132	Substrates and Products (Substrate)
30	Subunits
45	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
2	Temperature Stability [°C]
11	Turnover Number [1/s]

Engineering

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Engineering on EC 1.1.1.23 - histidinol dehydrogenase

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Go to Protein Variants Search

C112A

Brassica oleracea

conserved Cys-112 is not involved in catalysis, Cys-112 corresponds to Cys-116 in Salmonella typhimurium

286326

C366S

4 entries

H261N

Salmonella enterica subsp. enterica serovar Typhimurium

mutation causes complete loss of Zn and activity

286325

additional information

Salmonella enterica subsp. enterica serovar Typhimurium

P10370

site-directed mutagenesis of hisD, resulting in the replacement of the five His-residues with asparagine or glutamine, causes an important decrease in kcat for His261 and His326

741455