1.1.1.215: gluconate 2-dehydrogenase
This is an abbreviated version!
For detailed information about gluconate 2-dehydrogenase, go to the full flat file.
Word Map on EC 1.1.1.215
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1.1.1.215
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2-keto-d-gluconic
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gluconobacter
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oxydans
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5-keto-d-gluconate
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gluconokinase
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6-phosphogluconate
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entner-doudoroff
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l-idonate
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cypripedii
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2.7.1.12
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synthesis
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medicine
- 1.1.1.215
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2-keto-d-gluconic
- gluconobacter
- oxydans
- 5-keto-d-gluconate
- gluconokinase
- 6-phosphogluconate
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entner-doudoroff
- l-idonate
- cypripedii
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2.7.1.12
- synthesis
- medicine
Reaction
Synonyms
2-HDH, 2-keto-D-gluconate reductase, 2-keto-D-gluconate-yielding D-gluconate dehydrogenase, 2-keto-L-gulonate reductase, 2-ketoaldonate reductase, 2-ketogluconate dehydrogenase, 2-ketogluconate reductase, 2KGA reductase, 2KGR, 2KR, FAD-GADH, GA2DH, GAD, GADH, gluconate dehydrogenase, gluconate-2-dehydrogenase, gluconate-2-DH, GluD, Gox0417, GOX1230, HDH, L-2-hydroxyacid dehydrogenase, NADP-gluconate 2-dehydrogenase, NADPH requiring 2-keto-L-gulonate reductase, reductase, 2-ketogluconate
ECTree
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Engineering
Engineering on EC 1.1.1.215 - gluconate 2-dehydrogenase
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additional information
identification of a gene cluster encoding NADPH-dependent, L-idonate forming, 2-keto-L-gulonate reductase and NAD+-dependent L-idonate 5-dehydrogenase which forms 5-keto-D-gluconate. These genes are involved in the fungal D-glcUA catabolism and the reaction catalyzed by the latter enzyme is a direct continuation for the previously identified reaction by the action of GluC. Generation of a gene gluD deletion mutant strain, phenotype, overview. Deletion of gluD does not result in reduced or no growth on D-glcUA as sole carbon source, but it results in a phenotype of accumulating 2-keto-L-gulonate when cultivating on D-glcUA
additional information
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identification of a gene cluster encoding NADPH-dependent, L-idonate forming, 2-keto-L-gulonate reductase and NAD+-dependent L-idonate 5-dehydrogenase which forms 5-keto-D-gluconate. These genes are involved in the fungal D-glcUA catabolism and the reaction catalyzed by the latter enzyme is a direct continuation for the previously identified reaction by the action of GluC. Generation of a gene gluD deletion mutant strain, phenotype, overview. Deletion of gluD does not result in reduced or no growth on D-glcUA as sole carbon source, but it results in a phenotype of accumulating 2-keto-L-gulonate when cultivating on D-glcUA
additional information
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identification of a gene cluster encoding NADPH-dependent, L-idonate forming, 2-keto-L-gulonate reductase and NAD+-dependent L-idonate 5-dehydrogenase which forms 5-keto-D-gluconate. These genes are involved in the fungal D-glcUA catabolism and the reaction catalyzed by the latter enzyme is a direct continuation for the previously identified reaction by the action of GluC. Generation of a gene gluD deletion mutant strain, phenotype, overview. Deletion of gluD does not result in reduced or no growth on D-glcUA as sole carbon source, but it results in a phenotype of accumulating 2-keto-L-gulonate when cultivating on D-glcUA
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additional information
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identification of a gene cluster encoding NADPH-dependent, L-idonate forming, 2-keto-L-gulonate reductase and NAD+-dependent L-idonate 5-dehydrogenase which forms 5-keto-D-gluconate. These genes are involved in the fungal D-glcUA catabolism and the reaction catalyzed by the latter enzyme is a direct continuation for the previously identified reaction by the action of GluC. Generation of a gene gluD deletion mutant strain, phenotype, overview. Deletion of gluD does not result in reduced or no growth on D-glcUA as sole carbon source, but it results in a phenotype of accumulating 2-keto-L-gulonate when cultivating on D-glcUA
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additional information
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cj0414 and cj0415 mutants lack GADH activity at either temperature. Cj0415 mutant does not exhibit gluconate-dependent respiration. Cj0415 mutant is defective in chicken colonization, but exhibits only a minor colonization defect in mice
additional information
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cj0414 and cj0415 mutants lack GADH activity at either temperature. Cj0415 mutant does not exhibit gluconate-dependent respiration. Cj0415 mutant is defective in chicken colonization, but exhibits only a minor colonization defect in mice
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additional information
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a mutant strain of Gluconobacter japonicus NBRC3271 is engineered to produce 2-dehydro-D-gluconate efficiently from a mixture of D-glucose and D-gluconate
additional information
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a mutant strain of Gluconobacter japonicus NBRC3271 is engineered to produce 2-dehydro-D-gluconate efficiently from a mixture of D-glucose and D-gluconate
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additional information
development of an efficient bacterial strain of Gluconobacter oxydans_tufB_ga2dh for the production of 2-dehydro-D-gluconate by overexpressing the ga2dh gene in Gluconobacter oxydans. Supply of sufficient oxygen enhances the positive effect of gene overexpression on 2-dehydro-D-gluconate production. Gluconobacter oxydans_tufB_ga2dh is a competitive species for use in 2-dehydro-D-gluconate production. Transgenic strains, evaluation and optimization, detailed overview
additional information
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development of an efficient bacterial strain of Gluconobacter oxydans_tufB_ga2dh for the production of 2-dehydro-D-gluconate by overexpressing the ga2dh gene in Gluconobacter oxydans. Supply of sufficient oxygen enhances the positive effect of gene overexpression on 2-dehydro-D-gluconate production. Gluconobacter oxydans_tufB_ga2dh is a competitive species for use in 2-dehydro-D-gluconate production. Transgenic strains, evaluation and optimization, detailed overview
additional information
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development of an efficient bacterial strain of Gluconobacter oxydans_tufB_ga2dh for the production of 2-dehydro-D-gluconate by overexpressing the ga2dh gene in Gluconobacter oxydans. Supply of sufficient oxygen enhances the positive effect of gene overexpression on 2-dehydro-D-gluconate production. Gluconobacter oxydans_tufB_ga2dh is a competitive species for use in 2-dehydro-D-gluconate production. Transgenic strains, evaluation and optimization, detailed overview
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additional information
DELTAgad, and DELTAgcd/DELTAgad mutants are indistinguishable from the wild-type with respect to their growth characteristics and morphologies in liquid or solid nutrient-rich media. In the DELTAgcd mutant, which does not produce gluconic acid, the enhanced production of antifungal compounds is associated with improved biocontrol activity against take-all disease of wheat, caused by Gaeumannomyces graminis var. tritici
additional information
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DELTAgad, and DELTAgcd/DELTAgad mutants are indistinguishable from the wild-type with respect to their growth characteristics and morphologies in liquid or solid nutrient-rich media. In the DELTAgcd mutant, which does not produce gluconic acid, the enhanced production of antifungal compounds is associated with improved biocontrol activity against take-all disease of wheat, caused by Gaeumannomyces graminis var. tritici
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