1.1.1.214: 2-dehydropantolactone reductase (Si-specific)
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For detailed information about 2-dehydropantolactone reductase (Si-specific), go to the full flat file.
Reaction
Synonyms
2-dehydropantoyl-lactone reductase (B-specific), 2-ketopantoyl lactone reductase, 2-oxopantoyl lactone reductase, conjugated polyketone reductase, conjugated polyketone reductase C2, CORT_0G03830, CPR, CPR-C1, CPR-C2, ketopantoyl lactone reductase, NADPH-dependent conjugated polyketone reductase, NADPH-dependent ketopantoyl lactone reductase, nicotinamide adenine dinucleotide phosphate-dependent ketopantoyl lactone reductase
ECTree
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Application
Application on EC 1.1.1.214 - 2-dehydropantolactone reductase (Si-specific)
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synthesis
enzyme is useful for production of chiral alcohols
synthesis
-
in a continuous feeding reaction, 200 mM ketopantolactone is reduced to (R)-pantolactone with 98% conversion and 99% enantiomeric excess within 2.0 h
synthesis
use of polyketone reductase (CPR), glucose dehydrogenase (GDH) and coenzyme NADP+ in organic-inorganic hybrid nanoflowers (hNFs) for the asymmetric reduction of ketopantolactone to synthesize (R)-(-)-pantolactone. The sodium alginate-coated hNF reactor successfully catalyzes the asymmetric synthesis of (R)-pantolactone, with satisfactory stereoselectivity and reusability in repeated batches
synthesis
whole-cell biotransformation process to produce D-pantolactone in a biphasic reaction system. Recombinant CPR and glucose dehydrogenase are co-expressed in Escherichia coli to simultaneously achieve the synthesis of D-PL and the regeneration of NADPH. Presence of 15% dichloromethane significantly inhibits the hydrolysis of ketopantolactone. In a fed-batch system, the D-pantolactone concentration reaches 0.77 mol per l in the reaction mixture at 7 h, and its enantiomeric excess is 99%
synthesis
-
use of polyketone reductase (CPR), glucose dehydrogenase (GDH) and coenzyme NADP+ in organic-inorganic hybrid nanoflowers (hNFs) for the asymmetric reduction of ketopantolactone to synthesize (R)-(-)-pantolactone. The sodium alginate-coated hNF reactor successfully catalyzes the asymmetric synthesis of (R)-pantolactone, with satisfactory stereoselectivity and reusability in repeated batches
-
synthesis
-
in a continuous feeding reaction, 200 mM ketopantolactone is reduced to (R)-pantolactone with 98% conversion and 99% enantiomeric excess within 2.0 h
-
synthesis
-
use of polyketone reductase (CPR), glucose dehydrogenase (GDH) and coenzyme NADP+ in organic-inorganic hybrid nanoflowers (hNFs) for the asymmetric reduction of ketopantolactone to synthesize (R)-(-)-pantolactone. The sodium alginate-coated hNF reactor successfully catalyzes the asymmetric synthesis of (R)-pantolactone, with satisfactory stereoselectivity and reusability in repeated batches
-
synthesis
-
whole-cell biotransformation process to produce D-pantolactone in a biphasic reaction system. Recombinant CPR and glucose dehydrogenase are co-expressed in Escherichia coli to simultaneously achieve the synthesis of D-PL and the regeneration of NADPH. Presence of 15% dichloromethane significantly inhibits the hydrolysis of ketopantolactone. In a fed-batch system, the D-pantolactone concentration reaches 0.77 mol per l in the reaction mixture at 7 h, and its enantiomeric excess is 99%
-
synthesis
-
use of polyketone reductase (CPR), glucose dehydrogenase (GDH) and coenzyme NADP+ in organic-inorganic hybrid nanoflowers (hNFs) for the asymmetric reduction of ketopantolactone to synthesize (R)-(-)-pantolactone. The sodium alginate-coated hNF reactor successfully catalyzes the asymmetric synthesis of (R)-pantolactone, with satisfactory stereoselectivity and reusability in repeated batches
-
synthesis
-
use of polyketone reductase (CPR), glucose dehydrogenase (GDH) and coenzyme NADP+ in organic-inorganic hybrid nanoflowers (hNFs) for the asymmetric reduction of ketopantolactone to synthesize (R)-(-)-pantolactone. The sodium alginate-coated hNF reactor successfully catalyzes the asymmetric synthesis of (R)-pantolactone, with satisfactory stereoselectivity and reusability in repeated batches
-
synthesis
-
use of polyketone reductase (CPR), glucose dehydrogenase (GDH) and coenzyme NADP+ in organic-inorganic hybrid nanoflowers (hNFs) for the asymmetric reduction of ketopantolactone to synthesize (R)-(-)-pantolactone. The sodium alginate-coated hNF reactor successfully catalyzes the asymmetric synthesis of (R)-pantolactone, with satisfactory stereoselectivity and reusability in repeated batches
-