1.1.1.211: long-chain-3-hydroxyacyl-CoA dehydrogenase

This is an abbreviated version!
For detailed information about long-chain-3-hydroxyacyl-CoA dehydrogenase, go to the full flat file.

Reaction

Synonyms

2-enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-oxoacyl-CoA thiolase, 3-hydroxyacyl-CoA dehydrogenase, beta-hydroxyacyl-CoA dehydrogenase, enoyl-coenzyme A (CoA) hydratase/3-hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase trifunctional protein, HADHA, LCHAD, LHCAD, long chain 3-hydroxyacyl-CoA dehydrogenase, long chain fatty acid oxidase, long-chain 3-hydroxy acyl-CoA dehydrogenase, long-chain 3-hydroxy-acyl-CoA dehydrogenase, long-chain 3-hydroxyacyl coenzyme A dehydrogenase, long-chain 3-hydroxyacyl-CoA dehydrogenase, long-chain L-3 hydroxyacyl-CoA dehydrogenase, mitochondrial trifunctional protein, More, MTP

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.211 long-chain-3-hydroxyacyl-CoA dehydrogenase

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Results	in table
2	Activating Compound
32	AA Sequence
6	Application
1	CAS Registry Number
3	Cloned(Commentary)
17	Cofactor
1482	Disease/ Diagnostics
4	Expression
22	General Information
2	Inhibitors
2	KM Value [mM]
14	Localization
7	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
46	Organism
6	Pathway
12	PDB ID
2	pH Optimum
8	Protein Variants
3	Purification (Commentary)
1	Reaction
3	Reaction Type
34	Reference
54	Source Tissue
10	Specific Activity [micromol/min/mg]
34	Substrates and Products (Substrate)
4	Subunits
52	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]

Expression

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Expression on EC 1.1.1.211 - long-chain-3-hydroxyacyl-CoA dehydrogenase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

in hepatocarcinoma, there is a significant downregulation of enzyme transcripts as compared to controls

Homo sapiens

P40939

761287

nickel strongly represses mitochondrial fatty acid oxidation, the pathway by which fatty acids are catabolized for energy, in both primary human lung fibroblasts and mouse embryonic fibroblasts

2 entries

the enzyme is expressed and distributed widely in maternal and fetal tissues during the middle trimester

Mus musculus

-

741474

nickel strongly represses mitochondrial fatty acid oxidation, the pathway by which fatty acids are catabolized for energy, in both primary human lung fibroblasts and mouse embryonic fibroblasts

Rattus norvegicus

Q64428

740102

nickel strongly represses mitochondrial fatty acid oxidation, the pathway by which fatty acids are catabolized for energy, in both primary human lung fibroblasts and mouse embryonic fibroblasts

Rattus norvegicus Wistar

-

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