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0.2
(1S)-Camphorquinone
-
in 0.1 M potassium phosphate, pH 7.4
63
1-butanol
-
in 0.1 M potassium phosphate, pH 7.4
0.0055
1-decanal
-
in 0.1 M potassium phosphate, pH 7.4
0.0026
1-Dodecanal
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.0027
1-heptanal
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.0096
1-palmitoyl-2-(5-oxovaleryl)sn-glycero-3-phosphocholine
-
pH 6.0, 30°C
0.3
1-propanal
-
in 0.1 M potassium phosphate, pH 7.4
0.0006
1-Tetradecanol
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.0057
16-ketoestrone
-
in 0.1 M potassium phosphate, pH 7.4
0.68
2,3-Butanedione
-
in 0.1 M potassium phosphate, pH 7.4
0.0065
2,3-heptanedione
-
in 0.1 M potassium phosphate, pH 7.4
0.014 - 0.051
2,3-Hexanedione
0.2
2,3-Pentanedione
-
in 0.1 M potassium phosphate, pH 7.4
0.048
2,4-decadienal
-
in 0.1 M potassium phosphate, pH 7.4
0.064
2,4-nonadienal
-
in 0.1 M potassium phosphate, pH 7.4
0.01
2-decenal
-
in 0.1 M potassium phosphate, pH 7.4
10.6
2-deoxygalactose
-
-
0.075
2-hexenal
-
in 0.1 M potassium phosphate, pH 7.4
0.017
2-nonenal
-
in 0.1 M potassium phosphate, pH 7.4
0.78
2-phenyl-1-propanol
-
in 0.1 M potassium phosphate, pH 7.4
0.052
2-phenyl-2-propenal
-
in 0.1 M potassium phosphate, pH 7.4
0.099
2-pyridinecarboxaldehyde
-
-
0.0009
20alpha-hydroxyprogesterone
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.001
20alpha-Isocorticosterone
-
and 20alpha-isocortisol, values below
0.0032 - 0.0095
21-Dehydrocortisol
0.31
3,4-hexanedione
-
in 0.1 M potassium phosphate, pH 7.4
0.07 - 0.129
3-deoxyglucosone
1.7
3-Nitrobenzaldehyde
pH 7.0, 45°C
0.046
3-Pyridinecarboxaldehyde
-
-
0.02
4-bromobenzaldehyde
-
-
0.005
4-carboxybenzaldehyde
-
-
0.03
4-hydroxynonenal
-
in 0.1 M potassium phosphate, pH 7.4
0.01
4-hydroxyphenylacetaldehyde
-
-
0.002 - 0.0035
4-nitrobenzaldehyde
0.004
4-Pyridinecarboxaldehyde
-
-
0.0002
5-Pregnene-3beta,20alpha-diol
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.0004
5alpha-pregnan-20alpha-ol-3-one
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.0008
5alpha-pregnane-3beta,20alpha-diol
in 0.1 M potassium phosphate, pH 7.4, at 25°C
1.1
acetaldehyde
-
in 50 mM MOPS buffer, pH 7.0, at 37°C
0.0097 - 3.3
benzaldehyde
113
D-glucose 6-phosphate
-
-
0.152 - 19.2
D-glucuronate
0.7
D-glucuronolactone
-
-
0.035
D-glyceraldehyde
-
-
0.073 - 0.74
D-lactoaldehyde
29.1
D-ribose-5-phosphate
-
-
399.5
D-sorbitol
in 50 mM sodium phosphate at pH 7.0 and 30°C
179.5
D-xylitol
in 50 mM sodium phosphate at pH 7.0 and 30°C
24.9
D-xylose-5-phosphate
-
-
0.02 - 730.2
DL-glyceraldehyde
0.025
geraniol
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.0004 - 0.0009
geranylgeraniol
21
glycolaldehyde
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.016
Indole-3-acetaldehyde
-
-
0.02 - 1
Isobutyraldehyde
0.056
isocaproaldehyde
in 0.1 M potassium phosphate, pH 7.4, at 25°C
2
isophthalaldehyde
pH 7.0, 45°C
287.2 - 416.8
L-arabinose
0.112 - 6.3
methylglyoxal
0.02
nerol
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.007
p-nitrobenzaldehyde
-
-
0.056
phenyl-1,2-propanedione
-
in 0.1 M potassium phosphate, pH 7.4
0.016 - 0.68
Phenylglyoxal
0.011
propionaldehyde
-
-
0.012 - 4.5
Pyridine-3-aldehyde
0.49
Pyridine-3-methanol
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.02
Pyridine-4-aldehyde
-
in 0.1 M potassium phosphate, pH 7.4
0.285
Succinic semialdehyde
-
-
0.0023 - 0.0033
trans,trans-farnesol
0.25
trans-2-buten-1-al
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.004
trans-2-decen-1-al
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.028
trans-2-hexen-1-al
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.0034
trans-2-nonen-1-al
in 0.1 M potassium phosphate, pH 7.4, at 25°C
additional information
additional information
-
0.015
1-butanal
-
in 0.1 M potassium phosphate, pH 7.4
0.091
1-butanal
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.0044
1-Decanol
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.082
1-Decanol
-
in 0.1 M potassium phosphate, pH 7.4
0.023
1-hexanal
-
in 0.1 M potassium phosphate, pH 7.4
0.112
1-hexanal
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.18
1-Hexanol
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.97
1-Hexanol
-
in 0.1 M potassium phosphate, pH 7.4
0.0007
1-nonanal
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.005
1-nonanal
-
in 0.1 M potassium phosphate, pH 7.4
0.011
1-nonanol
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.74
1-nonanol
-
in 0.1 M potassium phosphate, pH 7.4
0.0017
1-octanal
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.014
1-octanal
-
in 0.1 M potassium phosphate, pH 7.4
0.014
2,3-Hexanedione
-
in 0.1 M potassium phosphate, pH 7.4
0.051
2,3-Hexanedione
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.0032
21-Dehydrocortisol
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.0095
21-Dehydrocortisol
-
in 0.1 M potassium phosphate, pH 7.4
0.07
3-deoxyglucosone
-
in 0.1 M potassium phosphate, pH 7.4
0.129
3-deoxyglucosone
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.002
4-nitrobenzaldehyde
-
-
0.003
4-nitrobenzaldehyde
-
-
0.003
4-nitrobenzaldehyde
-
4-hydroxyphenylglycolaldehyde
0.0035
4-nitrobenzaldehyde
-
in 0.1 M potassium phosphate, pH 7.4
0.12
acrolein
-
in 0.1 M potassium phosphate, pH 7.4
0.0097
benzaldehyde
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.063
benzaldehyde
-
in 0.1 M potassium phosphate, pH 7.4
3.3
benzaldehyde
pH 7.0, 45°C
0.3
benzyl alcohol
in 0.1 M potassium phosphate, pH 7.4, at 25°C
2.1
benzyl alcohol
-
in 0.1 M potassium phosphate, pH 7.4
110
D-arabinose
pH 7.0, 45°C
448.4
D-arabinose
in 50 mM sodium phosphate at pH 7.0 and 30°C
0.4
D-erythrose
-
-
40
D-galactose
-
-
42.9
D-galactose
-
recombinant from E. coli
43.3
D-galactose
-
recombinant from baculovirus system in Spodoptera frugiperda cells
78
D-galactose
-
recombinant from E. coli
572
D-galactose
pH 7.0, 45°C
47.3
D-glucose
-
-
71.5
D-glucose
pH 6.8, 37°C
98.1
D-glucose
-
recombinant from E. coli
98.1
D-glucose
-
recombinant from baculovirus system in Spodoptera frugiperda cells
205
D-glucose
pH 6.8, 37°C
281
D-glucose
-
recombinant from E. coli
0.152
D-glucuronate
-
-
3.53
D-glucuronate
-
recombinant from baculovirus system in Spodoptera frugiperda cells
6.4
D-glucuronate
-
recombinant from E. coli
13.9
D-glucuronate
-
recombinant from E. coli
0.073
D-lactoaldehyde
-
in 0.1 M potassium phosphate, pH 7.4
0.74
D-lactoaldehyde
in 0.1 M potassium phosphate, pH 7.4, at 25°C
479.2
D-Lyxose
-
-
506
D-Lyxose
-
mutant H110Q
2740
D-Lyxose
-
mutant H110A
7
D-ribose
-
-
108.1
D-ribose
in 50 mM sodium phosphate at pH 7.0 and 30°C
377
D-ribose
pH 7.0, 45°C
2
D-xylose
-
-
5.04
D-xylose
-
recombinant fron baculovirus system in Spodoptera frugiperda cells
8.7
D-xylose
-
recombinant from E. coli
16.8
D-xylose
-
recombinant from E. coli
17
D-xylose
-
pH 6.2, 22°C
28.9
D-xylose
-
pH 6.2, 25°C, enzyme from normal heart
29
D-xylose
-
pH 6.2, 25°C, enzyme from ischemic heart
56
D-xylose
-
isozyme ALR 2, NADPH
61
D-xylose
-
isozyme ALR 1, NADPH
106
D-xylose
pH 7.0, 45°C
466.8
D-xylose
in 50 mM sodium phosphate at pH 7.0 and 30°C
861
D-xylose
-
mutant H110Q
1340
D-xylose
-
mutant H110A
0.02
DL-glyceraldehyde
-
-
0.02
DL-glyceraldehyde
-
pH 7.0, 25°C, recombinant wild-type enzyme
0.02
DL-glyceraldehyde
-
pH 7.0, 25°C, recombinant mutant R293A
0.02
DL-glyceraldehyde
-
pH 7.0, 25°C, recombinant mutant W219A
0.02
DL-glyceraldehyde
-
pH 7.0, 25°C, recombinant mutant W219E
0.025
DL-glyceraldehyde
-
-
0.03
DL-glyceraldehyde
-
-
0.03
DL-glyceraldehyde
-
pH 7.0, 25°C, recombinant mutant S226A
0.046
DL-glyceraldehyde
-
-
0.047
DL-glyceraldehyde
-
recombinant from E. coli
0.05
DL-glyceraldehyde
-
pH 7.0, 25°C, recombinant mutant R268A
0.071
DL-glyceraldehyde
-
pH 6.0, 25°C, healthy heart
0.08
DL-glyceraldehyde
-
-
0.0835
DL-glyceraldehyde
-
pH 6.0, 25°C, ischemic heart
0.0836
DL-glyceraldehyde
-
pH 6.0, 25°C, healthy heart, in presence of DTT
0.092
DL-glyceraldehyde
-
pH 6.2, 25°C, recombinant enzyme
0.0934
DL-glyceraldehyde
-
pH 6.0, 25°C, ischemic heart, in presence of DTT
0.0973
DL-glyceraldehyde
-
presence of peroxynitrite, pH 7.0, 37°C
0.11
DL-glyceraldehyde
-
pH 7.0, 25°C, recombinant mutant S210A
0.12
DL-glyceraldehyde
-
recombinant from E. coli
0.124
DL-glyceraldehyde
-
pH 7.0, 37°C
0.13
DL-glyceraldehyde
-
pH 7.0, 25°C, recombinant mutant S214A
0.1734
DL-glyceraldehyde
-
presence of dimedone, pH 7.0, 37°C
0.19
DL-glyceraldehyde
-
pH 6.2, 25°C, enzyme from ischemic heart
0.2
DL-glyceraldehyde
-
pH 6.2, 25°C, enzyme from normal heart
0.42
DL-glyceraldehyde
-
pH 7.0, 25°C, recombinant mutant G213S
0.4287
DL-glyceraldehyde
-
presence of peroxynitrite and dimedone, pH 7.0, 37°C
0.5
DL-glyceraldehyde
-
pH 7.0, 25°C, recombinant mutant DELTA214-219
0.585
DL-glyceraldehyde
-
isoform ALR2, pH 6.2, 30°C
0.6
DL-glyceraldehyde
-
pH 7.0, 25°C, recombinant mutant C298A
1.1
DL-glyceraldehyde
pH 6.2, temperature not specified in the publication, recombinant His-tagged enzyme
2
DL-glyceraldehyde
-
in 0.1 M potassium phosphate, pH 7.4
3.4
DL-glyceraldehyde
-
-
3.7
DL-glyceraldehyde
-
pH 7.0, 25°C, recombinant mutant G213P
4
DL-glyceraldehyde
in 50 mM sodium phosphate at pH 7.0 and 30°C
6
DL-glyceraldehyde
pH 7.0, 25°C, recombinant detagged enzyme
12
DL-glyceraldehyde
-
mutant H110Q
64
DL-glyceraldehyde
-
mutant Y48S
71
DL-glyceraldehyde
-
mutant Y48H
84
DL-glyceraldehyde
-
mutant H110A
730.2
DL-glyceraldehyde
-
-
130.2
galactose
-
-
0.0004
geranylgeraniol
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.0009
geranylgeraniol
in 0.1 M potassium phosphate, pH 7.4, at 25°C
21.8
glucose
-
-
1.5
glycoaldehyde
-
in 0.1 M potassium phosphate, pH 7.4
1.28
Glyoxal
-
in 0.1 M potassium phosphate, pH 7.4
11
Glyoxal
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.034
hexanal
-
-
0.0022
isatin
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.069
isatin
-
in 0.1 M potassium phosphate, pH 7.4
0.02
Isobutyraldehyde
-
-
1
Isobutyraldehyde
-
in 50 mM MOPS buffer, pH 7.0, at 37°C
287.2
L-arabinose
-
-
0.018
L-glyceraldehyde
-
-
0.018
L-glyceraldehyde
-
recombinant from baculovirus system with Spodoptera frugiperda cells
0.8
L-idose
pH 6.8, 37°C
100
L-Xylose
-
-
360
L-Xylose
-
mutant H110A
1190
L-Xylose
-
mutant H110Q
0.112
methylglyoxal
-
recombinant enzyme, in 100 mM sodium phosphate buffer (pH 7.0), at 25°C, in the presence of 0.3 mM glutathione
0.26
methylglyoxal
-
in 0.1 M potassium phosphate, pH 7.4
0.4
methylglyoxal
-
recombinant enzyme, in 100 mM sodium phosphate buffer (pH 7.0), at 25°C, in the presence of 0.3 mM trypanothione
1.2
methylglyoxal
pH 6.2, temperature not specified in the publication, recombinant His-tagged enzyme
0.22
NADH
-
-
0.0032
NADPH
-
-
0.004
NADPH
-
recombinant from baculovirus system in Spodoptera frugiperda cells
0.054
NADPH
-
isoform ALR2, pH 6.2, 30°C
0.232
NADPH
pH 6.0, 30°C, ALR2
0.016
Phenylglyoxal
-
in 0.1 M potassium phosphate, pH 7.4
0.012
Pyridine-3-aldehyde
-
in 0.1 M potassium phosphate, pH 7.4
0.039
Pyridine-3-aldehyde
-
-
0.13
Pyridine-3-aldehyde
in 0.1 M potassium phosphate, pH 7.4, at 25°C
4.5
Pyridine-3-aldehyde
pH 7.0, 45°C
0.0023
trans,trans-farnesol
in 0.1 M potassium phosphate, pH 7.4, at 25°C
0.0033
trans,trans-farnesol
in 0.1 M potassium phosphate, pH 7.4, at 25°C
1.67
xylose
-
-
additional information
additional information
-
kinetics
-
additional information
additional information
-
brief investigation of steady state kinetic
-
additional information
additional information
-
steady-state kinetics
-
additional information
additional information
-
steady-state kinetics
-
additional information
additional information
Michaelis-Menten kinetics
-
additional information
additional information
-
Michaelis-Menten kinetics
-
additional information
additional information
the enzyme generates non-hyperbolic kinetics, mimicking a negative cooperative behavior, due to the simultaneous action of two enzyme forms acting on the same substrate. The apparent cooperative behavior of AR acting on glucose and other hexoses and pentoses, but not on tethroses, glyceraldehyde, 4-hydroxynonenal and 4-nitrobenzaldehyde, is generated by a partial nonclassical competitive inhibition exerted by the aldose hemiacetal on the reduction of the free aldehyde, Michaelis-Menten kinetic modelling with substrate L-idose, nonclassical competitive model, detailed overview
-
additional information
additional information
-
the enzyme generates non-hyperbolic kinetics, mimicking a negative cooperative behavior, due to the simultaneous action of two enzyme forms acting on the same substrate. The apparent cooperative behavior of AR acting on glucose and other hexoses and pentoses, but not on tethroses, glyceraldehyde, 4-hydroxynonenal and 4-nitrobenzaldehyde, is generated by a partial nonclassical competitive inhibition exerted by the aldose hemiacetal on the reduction of the free aldehyde, Michaelis-Menten kinetic modelling with substrate L-idose, nonclassical competitive model, detailed overview
-
additional information
additional information
the enzyme generates non-hyperbolic kinetics, mimicking a negative cooperative behavior, due to the simultaneous action of two enzyme forms acting on the same substrate. The apparent cooperative behavior of AR acting on glucose and other hexoses and pentoses, but not on tethroses, glyceraldehyde, 4-hydroxynonenal and 4-nitrobenzaldehyde, is generated by a partial nonclassical competitive inhibition exerted by the aldose hemiacetal on the reduction of the free aldehyde, Michaelis-Menten kinetic modelling with substrate L-idose, nonclassical competitive model, detailed overview
-
additional information
additional information
-
the enzyme generates non-hyperbolic kinetics, mimicking a negative cooperative behavior, due to the simultaneous action of two enzyme forms acting on the same substrate. The apparent cooperative behavior of AR acting on glucose and other hexoses and pentoses, but not on tethroses, glyceraldehyde, 4-hydroxynonenal and 4-nitrobenzaldehyde, is generated by a partial nonclassical competitive inhibition exerted by the aldose hemiacetal on the reduction of the free aldehyde, Michaelis-Menten kinetic modelling with substrate L-idose, nonclassical competitive model, detailed overview
-