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1.1.1.203: uronate dehydrogenase

This is an abbreviated version!
For detailed information about uronate dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.203

Reaction

beta-D-galacturonate
+
NAD+
=
D-galactaro-1,5-lactone
+
NADH
+
H+

Synonyms

Atu3143, CsUDH, D-galacturonate (uronate) dehydrogenase, D-GalUA oxidoreductase, EC 1.2.1.35, galacturonate acid reductase, galacturonate oxidoreductase, GalUR, Gor, PfUDH, PmUDH, PnUDH, poly-d-galacturonase, PSPTO_1053, PsUDH, Udh, uronate dehydrogenase, uronate:NAD-oxidoreductase, uronic acid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.203 uronate dehydrogenase

Crystallization

Crystallization on EC 1.1.1.203 - uronate dehydrogenase

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
crystal structures of an apo-form, a ternary form in complex with NADH and product, and an inactive Y136A mutant in complex with NAD+. Enzyme is a homohexamer. The monomer contains a Rossmann fold, essential for nucleotide binding. The ternary complex structure reveals a product, D-galactaro-1,5-lactone, which is bound above the nicotinamide ring. This product rearranges in solution to D-galactaro-1,4-lactone
enzyme structure, PDB ID 3AY3
-
sitting drop vapor diffusion method, using 0.1 M MES pH6.5 and 30% (w/v) 2-methyl-2-4-pentanediol