1.1.1.201: 7beta-hydroxysteroid dehydrogenase (NADP+)
This is an abbreviated version!
For detailed information about 7beta-hydroxysteroid dehydrogenase (NADP+), go to the full flat file.
Word Map on EC 1.1.1.201
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1.1.1.201
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synthesis
-
ursodeoxycholic
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taurinates
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dehydrogenases
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nadph-dependent
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aerofaciens
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bile
- 1.1.1.201
- synthesis
-
ursodeoxycholic
-
taurinates
- dehydrogenases
-
nadph-dependent
- aerofaciens
- bile
Reaction
Synonyms
7beta-HSD, 7beta-HSDH, 7beta-hydroxysteroid dehydrogenase, More, NADP-dependent 7beta-hydroxysteroid dehydrogenase, RUMGNA_02585
ECTree
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Reference
Reference on EC 1.1.1.201 - 7beta-hydroxysteroid dehydrogenase (NADP+)
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MacDonald, I.A.; Roach, P.D.
Bile induction of 7alpha- and 7beta-hydroxysteroid dehydrogenases in Clostridium absonum
Biochim. Biophys. Acta
665
262-269
1981
Clostridium sardiniense
Macdonald, I.A.; Rochon, Y.P.; Hutchinson, D.M.; Holdeman, L.V.
Formation of ursodeoxycholic acid from chenodeoxycholic acid by a 7beta-hydroxysteroid dehydrogenase-elaborating Eubacterium aerofaciens strain cocultured with 7alpha-hydroxysteroid dehydrogenase-elaborating organisms
Appl. Environ. Microbiol.
44
1187-1195
1982
Collinsella aerofaciens
Hirano, S.; Masuda, N.
Characterization of NADP-dependent 7beta-hydroxysteroid dehydrogenases from Peptostreptococcus productus and Eubacterium aerofaciens
Appl. Environ. Microbiol.
43
1057-1063
1982
Collinsella aerofaciens, Blautia producta
Sutherland, J.D.; Williams, C.N.
Bile acid induction of 7alpha- and 7beta-hydroxysteroid dehydrogenases in Clostridium limosum
J. Lipid Res.
26
344-350
1985
Hathewaya limosa
Edenharder, R.; Pfutzner, A.; Hammann, R.
Characterization of NAD-dependent 3alpha- and 3beta-hydroxysteroid dehydrogenase and of NADP-dependent 7beta-hydroxysteroid dehydrogenase from Peptostreptococcus productus
Biochim. Biophys. Acta
1004
230-238
1989
Blautia producta
Edenharder, R.; Pfutzner, A.; Hammann, R.
NADP-dependent 3beta-, 7alpha- and 7beta-hydroxysteroid dehydrogenase activities from a lecithinase-lipase-negative Clostridium species 25.11.c
Biochim. Biophys. Acta
1002
37-44
1989
Clostridium sp., Clostridium sp. 25.11.c
Shiotsuki, H.; Maeda, Y.; Chijiiwa, K.
Purification and characterization of 7beta-hydroxysteroid dehydrogenase from rabbit liver microsomes
J. Steroid Biochem. Mol. Biol.
91
185-190
2004
Oryctolagus cuniculus
Liu, L.; Aigner, A.; Schmid, R.D.
Identification, cloning, heterologous expression, and characterization of a NADPH-dependent 7beta-hydroxysteroid dehydrogenase from Collinsella aerofaciens
Appl. Microbiol. Biotechnol.
90
127-135
2011
Collinsella aerofaciens, Collinsella aerofaciens DSM 3979
Eggert, T.; Bakonyi, D.; Hummel, W.
Enzymatic routes for the synthesis of ursodeoxycholic acid
J. Biotechnol.
191
11-21
2014
Clostridium sardiniense, [Clostridium] scindens, Paeniclostridium sordellii, Collinsella aerofaciens, Fusarium equiseti
Lee, J.Y.; Arai, H.; Nakamura, Y.; Fukiya, S.; Wada, M.; Yokota, A.
Contribution of the 7beta-hydroxysteroid dehydrogenase from Ruminococcus gnavus N53 to ursodeoxycholic acid formation in the human colon
J. Lipid Res.
54
3062-3069
2013
[Ruminococcus] gnavus (A7B4V1), [Ruminococcus] gnavus ATCC 29149 (A7B4V1)
Savino, S.; Ferrandi, E.E.; Forneris, F.; Rovida, S.; Riva, S.; Monti, D.; Mattevi, A.
Structural and biochemical insights into 7beta-hydroxysteroid dehydrogenase stereoselectivity
Proteins
84
859-865
2016
Collinsella aerofaciens (A4ECA9), Collinsella aerofaciens ATCC 25986 (A4ECA9)
Wang, R.; Wu, J.; Jin, D.K.; Chen, Y.; Lv, Z.; Chen, Q.; Miao, Q.; Huo, X.; Wang, F.
Structure of NADP+-bound 7beta-hydroxysteroid dehydrogenase reveals two cofactor-binding modes
Acta Crystallogr. Sect. F
73
246-252
2017
Collinsella aerofaciens, Collinsella aerofaciens ATCC 25986
Zhang, X.; Fan, D.; Hua, X.; Zhang, T.
Large-scale production of ursodeoxycholic acid from chenodeoxycholic acid by engineering 7alpha- and 7beta-hydroxysteroid dehydrogenase
Bioprocess Biosyst. Eng.
42
1537-1545
2019
[Ruminococcus] torques, [Ruminococcus] torques ATCC 35915
Zheng, M.M.; Chen, K.C.; Wang, R.F.; Li, H.; Li, C.X.; Xu, J.H.
Engineering 7beta-hydroxysteroid dehydrogenase for enhanced ursodeoxycholic acid production by multiobjective directed evolution
J. Agric. Food Chem.
65
1178-1185
2017
[Ruminococcus] torques, [Ruminococcus] torques ATCC 35915
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