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1.1.1.200: aldose-6-phosphate reductase (NADPH)

This is an abbreviated version!
For detailed information about aldose-6-phosphate reductase (NADPH), go to the full flat file.

Word Map on EC 1.1.1.200

Reaction

D-sorbitol 6-phosphate
+
NADP+
=
D-glucose 6-phosphate
+
NADPH
+
H+

Synonyms

A6PR, A6PR1, A6PR2, A6PRase, Ald6PRase, alditol 6-phosphate:NADP 1-oxidoreductase, aldose-6-P reductase, aldose-6-phosphate reductase, aldose-6-phosphate reductase [NADPH], NADP-S6PDH, NADPH-dependent aldose 6-phosphate reductase, reductase, aldose 6-phosphate, S6PDH, sorbitol-6-phosphate dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.200 aldose-6-phosphate reductase (NADPH)

Inhibitors

Inhibitors on EC 1.1.1.200 - aldose-6-phosphate reductase (NADPH)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
AgNO3
-
complete inhibition at 0.1 mM
CaCl2
-
2.5 mM, in presence of 50 mM substrate, 12% decrease in activity
cysteine
-
47% inhibition of oxidation and 11% inhibition of reduction at 10 mM
D-fructose 1,6-bisphosphate
about 40% inhibition at 20 mM
D-fructose 6-phosphate
about 40% inhibition at 20 mM
D-galactose 1-phosphate
about 40% inhibition at 20 mM
D-glucose 1-phosphate
about 55% inhibition at 20 mM
D-ribose 5-phosphate
about 40% inhibition at 20 mM
Diamide
enzymatic activity decreases to approximately 7% at 500 mM diamide
H2O2
H2O2 oxidation causes enzyme inactivation in a time- and concentration-dependent manner
iodoacetate
-
42% inhibition of oxidation and 19% inhibition of reduction at 10 mM
mannose 1-phosphate
about 40% inhibition at 20 mM
mannose 6-phosphate
about 30% inhibition at 20 mM
MgCl2
-
2.5 mM, in presence of 50 mM substrate, 12% decrease in activity
Na2EDTA
-
35% inhibition of oxidation and 11% inhibition of reduction at 10 mM
NaCl
200 mM cause about 65% inhibition of the enzyme activity
p-chloromercuribenzoate
-
complete inhibition at 1.0 mM
phosphate
ZnCl2
-
2 mM, 58% inhibition, partially reversible by EDTA
ZnSO4
-
complete inhibition of oxidation and 80% inhibition of reduction at 1.25 mM
additional information
-