1.1.1.2: alcohol dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about alcohol dehydrogenase (NADP+), go to the full flat file.

Reaction

Synonyms

2� Adh, 3-DG-reducing enzyme, A3L14_07690, AAur_2040, ADH, ADH-1, ADH-2, ADH-I, ADH-II, ADH2, Adh319, ADH4, Adh6, AdhA, AdhB, AdhD, AKR1A1, AKR1A4, alcohol dehydrogenase C, alcohol dehydrogenase D, alcohol dehydrogenase [NADP(+)], Alcohol dehydrogenase [NADP+], aldehyde reductase, aldehyde reductase (NADPH2), aldehyde/ketone reductase, aldo-keto reductase, Aldo-keto reductase family 1 member A1, aldose reductase, ALDR, alipathic aldehyde reductase, ALR, ALR 1, ALR1, BdhA, bovine brain aldehyde reductase, CbADH, D-glucuronate reductase, daunorubicin reductase, DRD, EhADH1, FeADH, Gre2p, hexogenate dehydrogenase, high-Km aldehyde reductase, HvADH2, iron-containing alcohol dehydrogenase, KpADH, L-hexonate dehydrogenase, LB-RADH, LBADH, liver alcohol dehydrogenase, low-Km aldehyde reductase, mevaldate reductase, Mpd1, NADP(H)-dependent alcohol dehydrogenase, NADP+-dependent alcohol dehydrogenase, NADP-alcohol dehydrogenase, NADP-aldehyde reductase, NADP-dependent aldehyde reductase, NADP-linked aryl alcohol dehydrogenase, NADPH-aldehyde reductase, NADPH-cytochrome c reductase, NADPH-dependent ADH, NADPH-dependent aldehyde reductase, NADPH-dependent FALDR, NADPH-dependent fatty aldehyde reductase, NADPH-linked aldehyde reductase, nonspecific succinic semialdehyde reductase, Octopine dehydrogenase, putative iron alcohol dehydrogenase, PyAeADHII, rabbit kidney aldehyde-ketone reductase, RADH, ScADHVI, short-chain ADH, short-chain alcohol dehydrogenase, short-chain dehydrogenase/reductase, TBADH, TbADH1, Teth39_1597, Teth514_0564, TPN-L-hexonate dehydrogenase, TPNH-linked aldehyde reductase, TPNH-specific aldehyde reductase, triphosphopyridine nucleotide-linked aldehyde reductase, TsAdh319, Y63 protein, yeast alcohol dehydrogenase, YqhD

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.2 alcohol dehydrogenase (NADP+)

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Results	in table
11	Activating Compound
3079	AA Sequence
50	Application
1	CAS Registry Number
41	Cloned(Commentary)
97	Cofactor
25	Crystallization (Commentary)
1016	Disease/ Diagnostics
2	Expression
12	General Information
9	General Stability
33	IC50 Value
349	Inhibitors
70	kcat/KM [mM/s]
2	Ki Value [mM]
666	KM Value [mM]
36	Localization
29	Metals/Ions
171	Molecular Weight [Da]
234	Natural Substrates/ Products (Substrates)
7	Organic Solvent Stability
378	Organism
4	Oxidation Stability
18	Pathway
108	PDB ID
79	pH Optimum
12	pH Range
4	pH Stability
5	pI Value
63	Protein Variants
83	Purification (Commentary)
3	Reaction
5	Reaction Type
311	Reference
370	Source Tissue
149	Specific Activity [micromol/min/mg]
28	Storage Stability
1439	Substrates and Products (Substrate)
127	Subunits
167	Synonyms
1	Systematic Name
38	Temperature Optimum [°C]
5	Temperature Range [°C]
51	Temperature Stability [°C]
146	Turnover Number [1/s]

Organic Solvent Stability

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Organic Solvent Stability on EC 1.1.1.2 - alcohol dehydrogenase (NADP+)

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ORGANIC SOLVENT

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

acetonitrile

Haloferax volcanii

-

62% remaining activity at 10% after 72 h at 5°C, 34% at 5°C, rapid inactivation at 50°C and 30%

722209

DMSO

Haloferax volcanii

-

78% remaining activity at 30% after 72 h at 5°C, inactivation within 24 h at 50°C and 30%

722209

isopropanol

Thermococcus guaymasensis

F8S123

solvent-tolerant enzyme, highly efficient reduction of ketones by coupling with excess isopropanol to regenerate NADPH

738511

Methanol

2 entries

tetrahydrofuran

Haloferax volcanii

-

at 5°C, 32% activity remaining after 24 h, 7% after 72 h at 5% THF, 12% remaining activity at 10% THF after 24 h, inactivation within 72 h at 10% THF, and within 24 h at 30%THF

722209

additional information

Haloferax volcanii

-

longterm effects of organic solvents at 5°C and 50°C, overview. High concentration of salt, essential to maintain the enzymatic activity and structural integrity of the halophilic enzyme under standard conditions may be partially replaced by DMSO and MeOH. Presence of organic solvents does not induce gross changes in substrate specificity

722209

Methanol

Haloferax volcanii

-

at 5°C and 50°C, 38% remaining activity at 30%, 67% at 10%, and 70% at 5% after 72 h, inactivation within 24 h at 50°C and 30%

722209

Methanol

Thermococcus guaymasensis

F8S123

the purified enzyme does not oxidize methanol. The enzyme retains almost its full activity when the concentration of methanol is up to 5% (v/v). When the concentration of methanol is 40% (v/v) in the assay mixture, the enzyme activities remain at 30% and 15% of the full activity on both oxidation and reduction, respectively

738511