1.1.1.189: prostaglandin-E2 9-reductase
This is an abbreviated version!
For detailed information about prostaglandin-E2 9-reductase, go to the full flat file.
Word Map on EC 1.1.1.189
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1.1.1.189
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pgf2alpha
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luteal
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indomethacin
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corpora
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pseudopregnancy
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luteolysis
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13,14-dihydro-15-keto
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cyclooxygenases
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furosemide
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medicine
- 1.1.1.189
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pgf2alpha
- luteal
- indomethacin
-
corpora
-
pseudopregnancy
-
luteolysis
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13,14-dihydro-15-keto
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cyclooxygenases
- furosemide
- medicine
Reaction
Synonyms
20-alpha-HSD, 20-alpha-hydroxysteroid dehydrogenase, 9-keto-prostaglandin E2 reductase, 9-ketoprostaglandin reductase, 9-KPR, CBR1, More, mPGES, PG 9-ketoreductase/carbonyl reductase, PGE 9-ketoreductase, PGE2 9-ketoreductase, PGE2-9-K, PGE2-9-ketoreductase, PGE2-9-OR, prostaglandin 9-ketoreductase, prostaglandin 9-ketoreductase/carbonyl reductase, prostaglandin E 9-ketoreductase, prostaglandin E2 9-ketoreductase, prostaglandin E2-9-oxoreductase, prostaglandin-E2 9-keto reductase, reductase, 15-hydroxy9-oxoprostaglandin
ECTree
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Natural Substrates Products
Natural Substrates Products on EC 1.1.1.189 - prostaglandin-E2 9-reductase
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REACTION DIAGRAM
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+
prostaglandin E2 + NADPH
prostaglandin F2alpha + NADP+
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key enzyme responsible for the control of prostaglandin levels in placental tissues
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r
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+
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together with PGF synthase this enzyme can be a key enzyme in the regulation of specific prostaglandines in the endometrium during the preimplantation period
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?
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+
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can influence the processes of luteolysis and can be involved in parturition and retention of fetal membranes
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?
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+
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might be an important factor in the cascade of events leading to uterine contractions and parturition
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?
prostaglandin F2alpha + NAD(P)+
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product is involved in bronchial, vascular, and arterial smooth muscle contraction
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r
prostaglandin H2 + NAD(P)H + H+
prostaglandin F2alpha + NAD(P)+
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product is involved in bronchial, vascular, and arterial smooth muscle contraction
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r
prostaglandin H2 + NAD(P)H + H+
prostaglandin F2alpha + NAD(P)+
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product is involved in bronchial, vascular, and arterial smooth muscle contraction
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r
prostaglandin H2 + NAD(P)H + H+
prostaglandin F2alpha + NAD(P)+
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product is involved in bronchial, vascular, and arterial smooth muscle contraction
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r
prostaglandin H2 + NAD(P)H + H+
prostaglandin F2alpha + NAD(P)+
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product is involved in bronchial, vascular, and arterial smooth muscle contraction
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r