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1.1.1.188: prostaglandin-F synthase

This is an abbreviated version!
For detailed information about prostaglandin-F synthase, go to the full flat file.

Word Map on EC 1.1.1.188

Reaction

(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate
+
NADP+
=
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
+
NADPH
+
H+

Synonyms

17beta-hydroxysteroid dehydrogenase type 5, 17betaHSD5, 20alpha-HSD/PGFS, 20alpha-hydroxysteroid dehydrogenase/prostaglandin F-synthase, 9,11-endoperoxidase reductase, AKR1B1, AKR1B3, AKR1B7, AKR1C3, Akr1cl, aldo-keto reductase, aldo-keto reductase 1C3, aldo-ketoreductase 1B1, ALDR1, ALR2, DD1, dihydrodiol dehydrogenase 1, LBRM2904_31.2170, LemaA.00019.a.B1, m-PGFS, More, NADPH-dependent prostaglandin D2 11-keto reductase, P100/11E, PG endoperoxide reductase, PGD 11-ketoreductase, PGD2 11-ketoreductase, PGF, PGF synthase, PGF synthase I, PGF synthase II, PGF2alpha synthase, PGF2alpha-synthase, PGF2alpha-synthetic activity, PGF2S, PGFS, PGFS I, PGFS-I, PGFS-II, PGFSI, PGFSII, PGH 9-,11-endoperoxide reductase, PGH2 9,11-endoperoxidase, PGH2 9,11-endoperoxide reductase, PGH2 9-,11-endoperoxide reductase, prostaglandin 11-keto reductase, prostaglandin 11-ketoreductase, prostaglandin D2 11-ketoreductase, prostaglandin D2-ketoreductase, prostaglandin F synthase, prostaglandin F synthase I, prostaglandin F synthase II, prostaglandin F synthetase, prostaglandin F2alpha synthase, prostaglandin F2alpha-synthase, prostaglandin-D2 11-reductase, prostaglandin-F2alpha synthase, prostamide/PGF synthase, prostamide/prostaglandin F synthase, reductase, 15-hydroxy-11-oxoprostaglandin, synthetase, prostaglandin F2alpha, Tc00.1047053508461.80, Tc00.1047053511287.49, TCDM_00059, TrcrA.00019.a.B1, type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase, vas deferens protein

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.188 prostaglandin-F synthase

Source Tissue

Source Tissue on EC 1.1.1.188 - prostaglandin-F synthase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
AKR1B3 mRNA 9 is expressed in preadipocytes, and its level increases about 4fold at day 1 after initiation of adipocyte differentiation, and then quickly decreases the following day to a level lower than that in the preadipocytes
Manually annotated by BRENDA team
-
expression of genes for PGE2 synthesis, with low levels of prostaglandin transporters and dehydrogenase
Manually annotated by BRENDA team
-
endothel, isozymes PGF synthase I and II
Manually annotated by BRENDA team
normal breast expresses very high levels of AKR1C3 relative to other tissues
Manually annotated by BRENDA team
-
low activity
Manually annotated by BRENDA team
-
production of PGE2, PGF2 and PGD2 and high prostaglandin turnover
Manually annotated by BRENDA team
-
peri- and postimplantation conceptus. Prostaglandin H synthase and prostaglandin E synthase are down-regulated, and prostaglandin G synthase, prostaglandin F synthase and carbonyl reductase/prostaglandin 9-reductase are down-regulated in conceptuses during trophoblasic elongation. After initiation of implantation, expression of prostaglandin G synthase, prostaglandin F synthase and carbonyl reductase/prostaglandin 9-reductase in conceptuses increases and remains higher until days 24-25 of pregnancy
Manually annotated by BRENDA team
isoform AKR1B1 is expressed at a high level during the menstrual cycle during the secretory phase and in both epithelial and stromal cells
Manually annotated by BRENDA team
-
isozyme PGF synthase II
Manually annotated by BRENDA team
isoform AKR1B1 is expressed at a high level during the menstrual cycle during the secretory phase and in both epithelial and stromal cells
Manually annotated by BRENDA team
-
glioblastoma cell
Manually annotated by BRENDA team
-
embryonic kidney cell, isozyme PGFS-I
Manually annotated by BRENDA team
keloid fibroblasts
Manually annotated by BRENDA team
-
low activity
Manually annotated by BRENDA team
-
co-localization of cyclooxygenase-1, prostaglandin F receptor and prostaglandin F synthase
Manually annotated by BRENDA team
-
peritoneal
Manually annotated by BRENDA team
high expression level
Manually annotated by BRENDA team
-
low activity
Manually annotated by BRENDA team
-
enzyme co-localizes with myelin basic protein in myelin sheaths but not in axons
Manually annotated by BRENDA team
-
dendrites and somata, isozyme PGF synthase I
Manually annotated by BRENDA team
-
cultured oligodendrocytes at 7 days in vitro express the enzyme in cytoplasmic processes where the enzyme is co-localized with myelin basic protein
Manually annotated by BRENDA team
low expression level
Manually annotated by BRENDA team
-
the enzyme is associated with the cyclooxygenase-II, COX-II
Manually annotated by BRENDA team
AKR1C3 is overexpressed in skin squamous cell carcinoma (SCC) and affects SCC growth via prostaglandin metabolism
Manually annotated by BRENDA team
high expression level
Manually annotated by BRENDA team
-
isozyme PGF synthase II
Manually annotated by BRENDA team
-
glioblastoma cell
Manually annotated by BRENDA team
-
low activity
Manually annotated by BRENDA team
-
lung fibroblast cell
Manually annotated by BRENDA team
additional information