1.1.1.184: carbonyl reductase (NADPH)

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For detailed information about carbonyl reductase (NADPH), go to the full flat file.

Word Map on EC 1.1.1.184

1.1.1.184

polyketide

reductases

anthracycline

aldo-keto

ketosynthase

cardiotoxicity

actinorhodin

6-deoxyerythronolide

enoylreductase

doxorubicinol

ketoreduction

n-acetylcysteamine

triketide

mycolactone

buruli

synthesis

stereocenters

4-chloro-3-oxobutanoate

angucycline

kreds

ulcerans

s-4-chloro-3-hydroxybutanoate

ketoacyl

stereocontrol

daunorubicinol

medicine

diagnostics

industry

drug development

food industry

Reaction

Synonyms

(R) specific carbonyl reductase, (S)-specific carbonyl reductase, 15-hydroxyprostaglandin dehydrogenase [NADP+], 2,5-diketo-D-gluconic acid reductase, Adipocyte P27 protein, aldehyde reductase 1, aldehyde reductase I, aldo-keto reductase, ALR3, AP27, carbonyl reductase, carbonyl reductase (NADPH), carbonyl reductase 1, carbonyl reductase 3, carbonyl reductase S1, CBR, CBR 1, CBR 3, CBR1, CBR3, CHCR, CHCR1, CHCR2, CHCR3, CR, CR125, crc1, CSCR1, Gox0644, Gox1615, hCBR1, ketoreductase, KLCR1, KR, LCR, LOC415661, LOC610164, microsomal carbonyl reductase, More, NADP+-dependent ADH, NADPH-carbonyl reductase, NADPH-dependent carbonyl reductase, NADPH-dependent carbonyl reductase S1, NCCR, nonspecific NADPH-dependent carbonyl reductase, peroxisomal-type carbonyl reductase, PHCR, prostaglandin 9-ketoreductase, Prostaglandin-E2 9-reductase, PTCR, R-specific carbonyl reductase, reductase S1, reductase, carbonyl, RLCR, SCR, SCR9, SDR21C1, secondary-alcohol: NADP+-oxidoreductase, short-chain (S)-1-phenyl-1,2-ethanediol dehydrogenase, short-chain carbonyl reductase, sniffer, SRED, SSCR, SyS1, tetrameric carbonyl reductase, Tm1743, Tm_1743, xenobiotic carbonyl reductase, xenobiotic ketone reductase, YGL039w1, YGL039w2, YtbE, YueD

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.184 carbonyl reductase (NADPH)

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Results	in table
8	Activating Compound
2197	AA Sequence
26	Application
3	CAS Registry Number
74	Cloned(Commentary)
93	Cofactor
18	Crystallization (Commentary)
221	Disease/ Diagnostics
4	Expression
15	General Information
6	General Stability
45	IC50 Value
263	Inhibitors
74	kcat/KM [mM/s]
15	Ki Value [mM]
380	KM Value [mM]
22	Localization
30	Metals/Ions
90	Molecular Weight [Da]
33	Natural Substrates/ Products (Substrates)
21	Organic Solvent Stability
295	Organism
6	Pathway
31	PDB ID
47	pH Optimum
10	pH Range
8	pH Stability
2	pI Value
2	Posttranslational Modification
64	Protein Variants
58	Purification (Commentary)
9	Reaction
3	Reaction Type
162	Reference
105	Source Tissue
143	Specific Activity [micromol/min/mg]
8	Storage Stability
832	Substrates and Products (Substrate)
88	Subunits
189	Synonyms
1	Systematic Name
38	Temperature Optimum [°C]
8	Temperature Range [°C]
22	Temperature Stability [°C]
209	Turnover Number [1/s]

Temperature Optimum

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Temperature Optimum on EC 1.1.1.184 - carbonyl reductase (NADPH)

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Sporidiobolus salmonicolor

assay at room temperature

40 - 50

45 - 50

Kluyveromyces marxianus

A0A0E4AX59, A0A0E4AY21

740466

Bacillus sp. (in: Bacteria)

E3W861

724049

Starmerella magnoliae

pH 7.0, reduction of ethyl 4-chloro-3-oxobutanoate

above 70°C

additional information

2 entries