1.1.1.184: carbonyl reductase (NADPH)

This is an abbreviated version!
For detailed information about carbonyl reductase (NADPH), go to the full flat file.

Reaction

Synonyms

(R) specific carbonyl reductase, (S)-specific carbonyl reductase, 15-hydroxyprostaglandin dehydrogenase [NADP+], 2,5-diketo-D-gluconic acid reductase, Adipocyte P27 protein, aldehyde reductase 1, aldehyde reductase I, aldo-keto reductase, ALR3, AP27, carbonyl reductase, carbonyl reductase (NADPH), carbonyl reductase 1, carbonyl reductase 3, carbonyl reductase S1, CBR, CBR 1, CBR 3, CBR1, CBR3, CHCR, CHCR1, CHCR2, CHCR3, CR, CR125, crc1, CSCR1, Gox0644, Gox1615, hCBR1, ketoreductase, KLCR1, KR, LCR, LOC415661, LOC610164, microsomal carbonyl reductase, More, NADP+-dependent ADH, NADPH-carbonyl reductase, NADPH-dependent carbonyl reductase, NADPH-dependent carbonyl reductase S1, NCCR, nonspecific NADPH-dependent carbonyl reductase, peroxisomal-type carbonyl reductase, PHCR, prostaglandin 9-ketoreductase, Prostaglandin-E2 9-reductase, PTCR, R-specific carbonyl reductase, reductase S1, reductase, carbonyl, RLCR, SCR, SCR9, SDR21C1, secondary-alcohol: NADP+-oxidoreductase, short-chain (S)-1-phenyl-1,2-ethanediol dehydrogenase, short-chain carbonyl reductase, sniffer, SRED, SSCR, SyS1, tetrameric carbonyl reductase, Tm1743, Tm_1743, xenobiotic carbonyl reductase, xenobiotic ketone reductase, YGL039w1, YGL039w2, YtbE, YueD

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.184 carbonyl reductase (NADPH)

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
8	Activating Compound
2197	AA Sequence
26	Application
3	CAS Registry Number
74	Cloned(Commentary)
93	Cofactor
18	Crystallization (Commentary)
221	Disease/ Diagnostics
4	Expression
15	General Information
6	General Stability
45	IC50 Value
263	Inhibitors
74	kcat/KM [mM/s]
15	Ki Value [mM]
380	KM Value [mM]
22	Localization
30	Metals/Ions
90	Molecular Weight [Da]
33	Natural Substrates/ Products (Substrates)
21	Organic Solvent Stability
295	Organism
6	Pathway
31	PDB ID
47	pH Optimum
10	pH Range
8	pH Stability
2	pI Value
2	Posttranslational Modification
64	Protein Variants
58	Purification (Commentary)
9	Reaction
3	Reaction Type
162	Reference
105	Source Tissue
143	Specific Activity [micromol/min/mg]
8	Storage Stability
832	Substrates and Products (Substrate)
88	Subunits
189	Synonyms
1	Systematic Name
38	Temperature Optimum [°C]
8	Temperature Range [°C]
22	Temperature Stability [°C]
209	Turnover Number [1/s]

KCat KM Value

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

KCat KM Value on EC 1.1.1.184 - carbonyl reductase (NADPH)

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to kcat/KM Value Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

kcat/KM VALUE [1/mMs^-1]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

80

(R)-2-butanol

Methanobacterium palustre

-

pH 7.5, 37°C

724899

27

(S)-2-butanol

Methanobacterium palustre

-

pH 7.5, 37°C

724899

50 - 56.7

1,2-naphthoquinone

4 entries

8.7 - 73.3

1,4-Naphthoquinone

4 entries

4 - 5.75

1-(3-methyl-1,4-dioxidoquinoxalin-2-yl)ethanone

2 entries

25 - 26

1-(3-methyl-4-oxidoquinoxalin-2-yl)ethanone

2 entries

1.4

2,3-Butanediol

Methanobacterium palustre

-

pH 7.5, 37°C

724899

25 - 31.7

2,3-Hexanedione

4 entries

0.99 - 6.4

2,3-Pentanedione

2 entries

42

2-butanol

Methanobacterium palustre

-

pH 7.5, 37°C

724899

9

2-butanone

Methanobacterium palustre

-

pH 7.5, 37°C

724899

1.3

2-Pentanone

Methanobacterium palustre

-

pH 7.5, 37°C

724899

81

2-propanol

Methanobacterium palustre

-

pH 7.5, 37°C

724899

1281

3-glutathionyl-hexanal

Homo sapiens

P16152

pH 8.4, 25°C

740481

4615

3-glutathionyl-nonanal

Homo sapiens

P16152

pH 8.4, 25°C

740481

885

3-glutathionyl-propanal

Homo sapiens

P16152

pH 8.4, 25°C

740481

0.17 - 0.25

4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone

2 entries

4.8 - 15.7

4-benzoylpyridine

4 entries

113 - 2828

9,10-phenanthrenequinone

6 entries

11

acetoin

Methanobacterium palustre

-

pH 7.5, 37°C

724899

13

cyclohexanone

Methanobacterium palustre

-

pH 7.5, 37°C

724899

23

Cyclopentanol

Methanobacterium palustre

-

pH 7.5, 37°C

724899

19

Cyclopentanone

Methanobacterium palustre

-

pH 7.5, 37°C

724899

11.2 - 18.3

daunorubicin

2 entries

203

diacetyl

Methanobacterium palustre

-

pH 7.5, 37°C

724899

0.035 - 0.12

doxorubicin

2 entries

18.3 - 21.7

isatin

4 entries

7.5 - 54.5

menadione

6 entries

11

methylglyoxal

Gluconobacter oxydans

Q5FQJ0, Q5FT75

pH 7.0, 25°C

724046

11600

NADP+

Methanobacterium palustre

-

pH 7.5, 37°C

724899

0.0013 - 5200

NADPH

4 entries

11.3 - 12.2

oracin

2 entries

8.2

Phenylglyoxal

Gluconobacter oxydans

Q5FQJ0, Q5FT75

pH 7.0, 25°C

724046

321

propanone

Methanobacterium palustre

-

pH 7.5, 37°C

724899

1.72 - 93.45

S-nitrosoglutathione

5 entries

50

1,2-naphthoquinone

Homo sapiens

P16152

wild-type, pH 7.4, 25°C

724718

50

1,2-naphthoquinone

Homo sapiens

P16152

wild-type, pH 7.4, 37°C

724718

56.7

1,2-naphthoquinone

Homo sapiens

P16152

after treatment with S-nitrosoglutathione, pH 7.4, 25°C

724718

56.7

1,2-naphthoquinone

Homo sapiens

P16152

enzyme modified by S-nitrosoglutathione, pH 7.4, 37°C

724718

8.7

1,4-Naphthoquinone

Homo sapiens

P16152

after treatment with S-nitrosoglutathione, pH 7.4, 25°C

724718

8.7

1,4-Naphthoquinone

Homo sapiens

P16152

enzyme modified by S-nitrosoglutathione, pH 7.4, 37°C

724718

73.3

1,4-Naphthoquinone

Homo sapiens

P16152

wild-type, pH 7.4, 25°C

724718

73.3

1,4-Naphthoquinone

Homo sapiens

P16152

wild-type, pH 7.4, 37°C

724718

4

1-(3-methyl-1,4-dioxidoquinoxalin-2-yl)ethanone

Gallus gallus

F1N8Y3

pH 7.4, 37°C

724831

5.75

1-(3-methyl-1,4-dioxidoquinoxalin-2-yl)ethanone

Sus scrofa

Q28960

pH 7.4, 37°C

724831

25

1-(3-methyl-4-oxidoquinoxalin-2-yl)ethanone

Sus scrofa

Q28960

pH 7.4, 37°C

724831

26

1-(3-methyl-4-oxidoquinoxalin-2-yl)ethanone

Gallus gallus

F1N8Y3

pH 7.4, 37°C

724831

25

2,3-Hexanedione

Homo sapiens

P16152

after treatment with S-nitrosoglutathione, pH 7.4, 25°C

724718

25

2,3-Hexanedione

Homo sapiens

P16152

enzyme modified by S-nitrosoglutathione, pH 7.4, 37°C

724718

31.6

2,3-Hexanedione

Homo sapiens

P16152

wild-type, pH 7.4, 25°C

724718

31.7

2,3-Hexanedione

Homo sapiens

P16152

wild-type, pH 7.4, 37°C

724718

0.99

2,3-Pentanedione

Gluconobacter oxydans

Q5FQJ0, Q5FT75

pH 7.0, 25°C

724046

6.4

2,3-Pentanedione

Gluconobacter oxydans

Q5FQJ0, Q5FT75

pH 7.0, 25°C

724046

0.17

4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone

Homo sapiens

P16152

enzyme modified by S-nitrosoglutathione, pH 7.4, 37°C

724718

0.25

4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone

Homo sapiens

P16152

wild-type, pH 7.4, 37°C

724718

4.8

4-benzoylpyridine

Homo sapiens

P16152

wild-type, pH 7.4, 25°C

724718

4.8

4-benzoylpyridine

Homo sapiens

P16152

wild-type, pH 7.4, 37°C

724718

15.7

4-benzoylpyridine

Homo sapiens

P16152

after treatment with S-nitrosoglutathione, pH 7.4, 25°C

724718

15.7

4-benzoylpyridine

Homo sapiens

P16152

enzyme modified by S-nitrosoglutathione, pH 7.4, 37°C

724718

113

9,10-phenanthrenequinone

Homo sapiens

P16152

wild-type, pH 7.4, 25°C

724718

113

9,10-phenanthrenequinone

Homo sapiens

P16152

wild-type, pH 7.4, 37°C

724718

148.3

9,10-phenanthrenequinone

Homo sapiens

O75828, P16152

wild-type, pH 7.4, temperature not specified in the publication

724714

533

9,10-phenanthrenequinone

Homo sapiens

P16152

after treatment with S-nitrosoglutathione, pH 7.4, 25°C

724718

533

9,10-phenanthrenequinone

Homo sapiens

P16152

enzyme modified by S-nitrosoglutathione, pH 7.4, 37°C

724718

2828

9,10-phenanthrenequinone

Homo sapiens

O75828, P16152

mutant C227S, pH 7.4, temperature not specified in the publication

724714

11.2

daunorubicin

Homo sapiens

P16152

enzyme modified by S-nitrosoglutathione, pH 7.4, 37°C

724718

18.3

daunorubicin

Homo sapiens

P16152

wild-type, pH 7.4, 37°C

724718

0.035

doxorubicin

Mus musculus

P48758, Q8K354

isoform Cbr3, at pH 7.0 and 37°C

760967

0.12

doxorubicin

Mus musculus

P48758, Q8K354

isoform Cbr1, at pH 7.0 and 37°C

760967

18.3

isatin

Homo sapiens

P16152

after treatment with S-nitrosoglutathione, pH 7.4, 25°C

724718

18.3

isatin

Homo sapiens

P16152

enzyme modified by S-nitrosoglutathione, pH 7.4, 37°C

724718

21.7

isatin

Homo sapiens

P16152

wild-type, pH 7.4, 25°C

724718

21.7

isatin

Homo sapiens

P16152

wild-type, pH 7.4, 37°C

724718

7.5

menadione

Sus scrofa

Q28960

pH 7.4, 37°C

724831

21.7

menadione

Homo sapiens

P16152

after treatment with S-nitrosoglutathione, pH 7.4, 25°C

724718

21.7

menadione

Homo sapiens

P16152

enzyme modified by S-nitrosoglutathione, pH 7.4, 37°C

724718

38.3

menadione

Homo sapiens

P16152

wild-type, pH 7.4, 25°C

724718

38.3

menadione

Homo sapiens

P16152

wild-type, pH 7.4, 37°C

724718

54.5

menadione

Gallus gallus

F1N8Y3

pH 7.4, 37°C

724831

0.0013

NADPH

Mus musculus

P48758, Q8K354

isoform Cbr3, at pH 7.0 and 37°C

760967

0.36

NADPH

Mus musculus

P48758, Q8K354

isoform Cbr1, at pH 7.0 and 37°C

760967

5185

NADPH

Homo sapiens

P16152

pH 8.4, 25°C

740481

5200

NADPH

Methanobacterium palustre

-

pH 7.5, 37°C

724899

11.3

oracin

Homo sapiens

P16152

enzyme modified by S-nitrosoglutathione, pH 7.4, 37°C

724718

12.2

oracin

Homo sapiens

P16152

wild-type, pH 7.4, 37°C

724718

1.72

S-nitrosoglutathione

Homo sapiens

O75828, P16152

mutant D236A/K238P/D239K/S240A/I241T/R242K/T243S/V244P, pH 7.4, temperature not specified in the publication

724714

2.5

S-nitrosoglutathione

Homo sapiens

O75828, P16152

mutant C227S, pH 7.4, temperature not specified in the publication

724714

9.93

S-nitrosoglutathione

Homo sapiens

O75828, P16152

mutant P230W/D236A/K238P/D239K/S240A/I241T/R242K/T243S/V244PpH 7.4, temperature not specified in the publication

724714

24.58

S-nitrosoglutathione

Homo sapiens

O75828, P16152

mutant Q142M/C143S/P230W/D236A/K238P/D239K/S240A/I241T/R242K/T243S/V244P/H270S, pH 7.4, temperature not specified in the publication

724714

93.45

S-nitrosoglutathione

Homo sapiens

O75828, P16152

wild-type, pH 7.4, temperature not specified in the publication

724714