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1.1.1.176: 12alpha-hydroxysteroid dehydrogenase

This is an abbreviated version!
For detailed information about 12alpha-hydroxysteroid dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.176

Reaction

cholate
+
NADP+
=
3alpha,7alpha-dihydroxy-12-oxo-5beta-cholan-24-oate
+
NADPH
+
H+

Synonyms

12alpha-HSDH, 12alpha-hydroxy steroid dehydrogenase, CDD59475, dehydrogenase, 12alpha-hydroxy steroid, Elen_2515, NAD+-dependent 12alpha-HSDH, NAD-dependent 12alpha-hydroxysteroid dehydrogenase, NADP+-dependent 12alpha-HSDH, NADP-12alpha-hydroxysteroid dehydrogenase, NADP-dependent 12alpha-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.176 12alpha-hydroxysteroid dehydrogenase

Reference

Reference on EC 1.1.1.176 - 12alpha-hydroxysteroid dehydrogenase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ottolina, G.; Riva, S.; Carrea, G.; Danieli, B.; Buckmann, A.F.
Enzymatic synthesis of [4R-2H]NAD (P)H and [4S-2H]NAD(P)H and determination of the stereospecificity of 7alpha- and 12alpha hydroxysteroid dehydrogenase
Biochim. Biophys. Acta
998
173-178
1989
Clostridium sp.
Manually annotated by BRENDA team
Kinoshita, S.; Kadota, K.; Inoue, T.; Sawada, H.; Taguchi, H.
Purification and properties of three kinds of alpha-hydroxysteroid dehydrogenase from Brevibacterium fuscum DC33
J. Ferment. Technol.
66
145-152
1988
Brevibacterium fuscum
-
Manually annotated by BRENDA team
Braun, M.; Lunsdorf, H.; Buckmann, A.F.
12 alpha-hydroxysteroid dehydrogenase from Clostridium group P, strain C 48-50. Production, purification and characterization
Eur. J. Biochem.
196
439-450
1991
Clostridium sp.
Manually annotated by BRENDA team
MacDonald, I.A.; Rochon, Y.P.
Affinity chromatography of bile salts 7alpha-, 7beta- and 12alpha-hydroxysteroid dehydrogenases on immobilized Procion Red and Cibacron Blue Sepharose 4B columns
J. Chromatogr.
259
154-158
1983
Clostridium sp.
Manually annotated by BRENDA team
MacDonald, I.A.; Jellett, J.F.; Mahony, D.E.; Holdeman, L.V.
Bile salt 3alpha- and 12alpha-hydroxysteroid dehydrogenases from Eubacterium lentum and related organisms
Appl. Environ. Microbiol.
37
992-1000
1979
Eggerthella lenta
Manually annotated by BRENDA team
Harris, J.N.; Hylemon, P.B.
Partial purification and characterization of NADP-dependent 12alpha-hydroxysteroid dehydrogenase from Clostridium leptum
Biochim. Biophys. Acta
528
148-157
1978
[Clostridium] leptum
Manually annotated by BRENDA team
Mahony, D.E.; Meier, C.E.; MacDonald, I.A.; Holdeman, L.V.
Bile salt degradation by nonfermentative clostridia
Appl. Environ. Microbiol.
34
419-423
1977
Clostridium sp.
Manually annotated by BRENDA team
MacDonald, I.A.; Mahony, D.E.; Jellet, J.F.; Meier, C.E.
NAD-dependent 3alpha- and 12alpha-hydroxysteroid dehydrogenase activities from Eubacterium lentum ATCC no. 25559
Biochim. Biophys. Acta
489
466-476
1977
Eggerthella lenta
Manually annotated by BRENDA team
MacDonald, I.A.; Meier, E.C.; Mahony, D.E.; Costain, G.A.
3alpha-, 7alpha- and 12alpha-hydroxysteroid dehydrogenase activities from Clostridium perfringens
Biochim. Biophys. Acta
450
142-153
1976
Clostridium perfringens
Manually annotated by BRENDA team
Panichajakul, S.; Tawat, K.; Yoshida, T.; Taguchi, H.
Purification and characterization of 12alpha-hydroxysteroid dehydrogenase from Brevibacterium fuscum DC 33
Microb. Util. Renewable Resour.
8
119-128
1993
Brevibacterium fuscum
-
Manually annotated by BRENDA team
Panichajakul, S.; Tawat, K.; Yoshida, T.; Taguchi, H.
Bile acids induction of 12 alpha-hydroxysteroid dehydrogenase in Brevibacterium fuscum
Microb. Util. Renewable Resour.
8
112-118
1993
Brevibacterium fuscum
-
Manually annotated by BRENDA team
Fossati, E.; Polentini, F.; Carrea, G.; Riva, S.
Exploitation of the alcohol dehydrogenase-acetone NADP-regeneration system for the enzymatic preparative-scale production of 12-ketochenodeoxycholic acid
Biotechnol. Bioeng.
93
1216-1220
2006
Clostridium sp.
Manually annotated by BRENDA team
Giovannini, P.P.; Grandini, A.; Perrone, D.; Pedrini, P.; Fantin, G.; Fogagnolo, M.
7alpha- and 12alpha-Hydroxysteroid dehydrogenases from Acinetobacter calcoaceticus lwoffii: a new integrated chemo-enzymatic route to ursodeoxycholic acid
Steroids
73
1385-1390
2008
Acinetobacter lwoffii
Manually annotated by BRENDA team
Eggert, T.; Bakonyi, D.; Hummel, W.
Enzymatic routes for the synthesis of ursodeoxycholic acid
J. Biotechnol.
191
11-21
2014
[Clostridium] leptum, Clostridium perfringens, Clostridium sp., Eggerthella lenta, Clostridium sp. ATCC 29733
Manually annotated by BRENDA team
Kollerov, V.V.; Lobastova, T.G.; Monti, D.; Deshcherevskaya, N.O.; Ferrandi, E.E.; Fronza, G.; Riva, S.; Donova, M.V.
Deoxycholic acid transformations catalyzed by selected filamentous fungi
Steroids
107
20-29
2016
Curvularia lunata, Curvularia lunata VKM F-644
Manually annotated by BRENDA team
Doden, H.; Sallam, L.A.; Devendran, S.; Ly, L.; Doden, G.; Daniel, S.L.; Alves, J.M.P.; Ridlon, J.M.
Metabolism of oxo-bile acids and characterization of recombinant 12alpha-hydroxysteroid dehydrogenases from bile acid 7alpha-dehydroxylating human gut bacteria
Appl. Environ. Microbiol.
84
e00235-18
2018
[Clostridium] scindens, Peptacetobacter hiranonis (B6FYX7), [Clostridium] hylemonae (C0BWQ2), [Clostridium] scindens ATCC 35704, Peptacetobacter hiranonis DSM 13275 (B6FYX7), [Clostridium] hylemonae DSM 15053 (C0BWQ2)
Manually annotated by BRENDA team
Mythen, S.; Devendran, S.; Méndez-García, C.; Cann, I.; Ridlon, J.
Targeted synthesis and characterization of a gene cluster encoding NAD(P)H-dependent 3alpha-, 3beta-, and 12alpha-hydroxysteroid dehydrogenases from Eggerthella CAG 298, a gut metagenomic sequence
Appl. Environ. Microbiol.
84
e02475-17
2018
Eggerthella sp. CAG:298 (R7AM69)
Manually annotated by BRENDA team
Harris, S.C.; Devendran, S.; Mendez-Garcia, C.; Mythen, S.M.; Wright, C.L.; Fields, C.J.; Hernandez, A.G.; Cann, I.; Hylemon, P.B.; Ridlon, J.M.
Bile acid oxidation by Eggerthella lenta strains C592 and DSM 2243T
Gut Microbes
9
523-539
2018
Eggerthella lenta, Eggerthella lenta C592, Eggerthella lenta DSM 2243T
Manually annotated by BRENDA team