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1.1.1.169: 2-dehydropantoate 2-reductase

This is an abbreviated version!
For detailed information about 2-dehydropantoate 2-reductase, go to the full flat file.

Word Map on EC 1.1.1.169

Reaction

(R)-pantoate
+
NADP+
=
2-dehydropantoate
+
NADPH
+
H+

Synonyms

2-dehydropantoate 2-reductase, 2-ketopantoate reductase, 2-ketopantoic acid reductase, 2-oxopantoate reductase, conjugated polyketone reductase, CPR, ilvC, ketopantoate reductase, ketopantoic acid reductase, KPA reductase, KPR, More, PanE, panG, Tk-KPR, TK1968, TK1968 protein

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.169 2-dehydropantoate 2-reductase

Reference

Reference on EC 1.1.1.169 - 2-dehydropantoate 2-reductase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kataoka, M.; Shimizu, S.; Yamada, H.
Novel enzymic production of D-(-)-pantoyl lactone through the stereospecific reduction of ketopantoic acid
Agric. Biol. Chem.
54
177-182
1990
Agrobacterium tumefaciens, Agrobacterium sp., Pseudomonas putida, Stenotrophomonas maltophilia
-
Manually annotated by BRENDA team
Shimizu, S.; Kataoka, M.; Ching-Ming Chung, M.; Yamada, H.
Ketopantoic acid reductase of Pseudomonas maltophilia 845. Purification, characterization, and role in pantothenate biosynthesis
J. Biol. Chem.
263
12077-12084
1988
Saccharomyces cerevisiae, Stenotrophomonas maltophilia, Stenotrophomonas maltophilia 845
Manually annotated by BRENDA team
King, H.L.; Wilken, D.R.
Separation and preliminary studies on 2-ketopantoyl lactone and 2-ketopantoic acid reductases of yeast
J. Biol. Chem.
247
4096-4098
1972
Saccharomyces cerevisiae, Saccharomyces cerevisiae NRRL Y-2034
-
Manually annotated by BRENDA team
Wilken, D.R.; King, H.L.; Dyar, R.E.
Ketopantoic acid and ketopantoyl lactone reductases. Stereospecificity of transfer of hydrogen from reduced nicotinamide adenine dinucleotide phosphate
J. Biol. Chem.
250
2311-2314
1975
Saccharomyces cerevisiae, Escherichia coli
Manually annotated by BRENDA team
Elischewski, F.; Puhler, A.; Kalinowski, J.
Pantothenate production in Escherichia coli K12 by enhanced expression of the panE gene encoding ketopantoate reductase
J. Biotechnol.
75
135-146
1999
Escherichia coli
Manually annotated by BRENDA team
Frodyma, M.E.; Downs, D.
ApbA, the ketopantoate reductase enzyme of Salmonella typhimurium is required for the synthesis of thiamine via the alternative pyrimidine biosynthetic pathway
J. Biol. Chem.
273
5572-5576
1998
Saccharomyces cerevisiae, Escherichia coli, Stenotrophomonas maltophilia, Salmonella enterica subsp. enterica serovar Typhimurium, Stenotrophomonas maltophilia 845, Escherichia coli BL21/lambdaDE3
Manually annotated by BRENDA team
Zheng, R.; Blanchard, J.S.
Kinetic and mechanistic analysis of the E. coli panE-encoded ketopantoate reductase
Biochemistry
39
3708-3717
2000
Escherichia coli
Manually annotated by BRENDA team
Zheng, R.; Blanchard, J.S.
Identification of active site residues in E. coli ketopantoate reductase by mutagenesis and chemical rescue
Biochemistry
39
16244-16251
2000
Escherichia coli
Manually annotated by BRENDA team
Matak-Vinkovic, D.; Vinkovic, M.; Saldanha, S.A.; Ashurst, J.L.; von Delft, F.; Inoue, T.; Miguel, R.N.; Smith, A.G.; Blundell, T.L.; Abell, C.
Crystal structure of Escherichia coli ketopantoate reductase at 1.7 A resolution and insight into the enzyme mechanism
Biochemistry
40
14493-14500
2001
Stenotrophomonas maltophilia, Salmonella enterica subsp. enterica serovar Typhimurium, Escherichia coli (P0A9J4), Escherichia coli, Stenotrophomonas maltophilia 845
Manually annotated by BRENDA team
Zheng, R.; Blanchard, J.S.
Substrate specificity and kinetic isotope effect analysis of the Eschericia coli ketopantoate reductase
Biochemistry
42
11289-11296
2003
Escherichia coli
Manually annotated by BRENDA team
Merkamm, M.; Chassagnole, C.; Lindley, N.D.; Guyonvarch, A.
Ketopantoate reductase activity is only encoded by ilvC in Corynebacterium glutamicum
J. Biotechnol.
104
253-260
2003
Corynebacterium glutamicum
Manually annotated by BRENDA team
Ciulli, A.; Abell, C.
Biophysical tools to monitor enzyme-ligand interactions of enzymes involved in vitamin biosynthesis
Biochem. Soc. Trans.
33
767-771
2005
Escherichia coli
Manually annotated by BRENDA team
Lobley, C.M.; Ciulli, A.; Whitney, H.M.; Williams, G.; Smith, A.G.; Abell, C.; Blundell, T.L.
The crystal structure of Escherichia coli ketopantoate reductase with NADP+ bound
Biochemistry
44
8930-8939
2005
Escherichia coli (P0A9J4), Escherichia coli
Manually annotated by BRENDA team
Ciulli, A.; Williams, G.; Smith, A.G.; Blundell, T.L.; Abell, C.
Probing hot spots at protein-ligand binding sites: a fragment-based approach using biophysical methods
J. Med. Chem.
49
4992-5000
2006
Escherichia coli
Manually annotated by BRENDA team
Ciulli, A.; Lobley, C.M.; Tuck, K.L.; Smith, A.G.; Blundell, T.L.; Abell, C.
pH-tuneable binding of 2-phospho-ADP-ribose to ketopantoate reductase: a structural and calorimetric study
Acta Crystallogr. Sect. D
63
171-178
2007
Escherichia coli (P0A9J4), Escherichia coli
Manually annotated by BRENDA team
Ciulli, A.; Chirgadze, D.Y.; Smith, A.G.; Blundell, T.L.; Abell, C.
Crystal structure of Escherichia coli ketopantoate reductase in a ternary complex with NADP+ and pantoate bound: substrate recognition, conformational change, and cooperativity
J. Biol. Chem.
282
8487-8497
2007
Escherichia coli (P0A9J4), Escherichia coli
Manually annotated by BRENDA team
Headey, S.J.; Vom, A.; Simpson, J.S.; Scanlon, M.J.
Backbone assignments of the 34 kDa ketopantoate reductase from E. coli
Biomol. NMR Assign.
2
93-96
2008
Escherichia coli (P0A9J4)
Manually annotated by BRENDA team
Miller, C.N.; LoVullo, E.D.; Kijek, T.M.; Fuller, J.R.; Brunton, J.C.; Steele, S.P.; Taft-Benz, S.A.; Richardson, A.R.; Kawula, T.H.
PanG, a new ketopantoate reductase involved in pantothenate synthesis
J. Bacteriol.
195
965-976
2013
Francisella tularensis subsp. novicida
Manually annotated by BRENDA team
Miyanaga, A.; Fujisawa, S.; Furukawa, N.; Arai, K.; Nakajima, M.; Taguchi, H.
The crystal structure of D-mandelate dehydrogenase reveals its distinct substrate and coenzyme recognition mechanisms from those of 2-ketopantoate reductase
Biochem. Biophys. Res. Commun.
439
109-114
2013
Enterococcus faecalis (E3USM3), Enterococcus faecalis IAM10071 (E3USM3), Enterococcus faecalis IAM10071
Manually annotated by BRENDA team
Tomita, H.; Imanaka, T.; Atomi, H.
Identification and characterization of an archaeal ketopantoate reductase and its involvement in regulation of coenzyme A biosynthesis
Mol. Microbiol.
90
307-321
2013
Thermococcus kodakarensis (Q5JGC2), Thermococcus kodakarensis, Thermococcus kodakarensis ATCC BAA-918 (Q5JGC2)
Manually annotated by BRENDA team
Aikawa, Y.; Nishitani, Y.; Tomita, H.; Atomi, H.; Miki, K.
Crystal structure of ketopantoate reductase from Thermococcus kodakarensis complexed with NADP(.)
Acta crystallogr. Sect. F
72
369-375
2016
Thermococcus kodakarensis (Q5JGC2), Thermococcus kodakarensis, Thermococcus kodakarensis ATCC BAA-918 (Q5JGC2)
Manually annotated by BRENDA team
Sanchez, J.E.; Gross, P.G.; Goetze, R.W.; Walsh, R.M.; Peeples, W.B.; Wood, Z.A.
Evidence of kinetic cooperativity in dimeric ketopantoate reductase from Staphylococcus aureus
Biochemistry
54
3360-3369
2015
Staphylococcus aureus (A0A0J9X283), Staphylococcus aureus
Manually annotated by BRENDA team
Aikawa, Y.; Nishitani, Y.; Tomita, H.; Atomi, H.; Miki, K.
Crystal structure of archaeal ketopantoate reductase complexed with coenzyme a and 2-oxopantoate provides structural insights into feedback regulation
Proteins
84
374-382
2016
Thermococcus kodakarensis (Q5JGC2), Thermococcus kodakarensis, Thermococcus kodakarensis ATCC BAA-918 (Q5JGC2)
Manually annotated by BRENDA team
Zhang, B.; Zhang, X.M.; Wang, W.; Liu, Z.Q.; Zheng, Y.G.
Metabolic engineering of Escherichia coli for D-pantothenic acid production
Food Chem.
294
267-275
2019
Escherichia coli, Escherichia coli W3110
Manually annotated by BRENDA team
Pei, X.; Wang, J.; Zheng, H.; Cheng, P.; Wu, Y.; Wang, A.; Su, W.
Highly efficient asymmetric reduction of ketopantolactone to D-(-)-pantolactone by Escherichia coli cells expressing recombinant conjugated polyketone reductase and glucose dehydrogenase in a fed-batch biphasic reaction system
React. Chem. Eng.
5
531-538
2020
Candida dubliniensis, Candida dubliniensis CD36
-
Manually annotated by BRENDA team