1.1.1.168: 2-dehydropantolactone reductase (Re-specific)
This is an abbreviated version!
For detailed information about 2-dehydropantolactone reductase (Re-specific), go to the full flat file.
Reaction
+
=
+
+
Synonyms
(R)-pantoyl-lactone:NADP+ oxidoreductase (A-specific), 2-dehydropantoyl-lactone reductase, 2-dehydropantoyl-lactone reductase (A-specific), 2-ketopantoyl lactone reductase, AKR, CPR, ketopantoyl lactone reductase, NADPH-dependent aldo-keto reductase, NADPH-dependent conjugated polyketone reductase, reductase, 2-oxopantoyl lactone
ECTree
Inhibitors
Inhibitors on EC 1.1.1.168 - 2-dehydropantolactone reductase (Re-specific)
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1,2-Cyclopentanedione
-
-
2-keto-4-hydroxybutyrolactone
-
-
2-Oxo-4-hydroxy-3-methylbutyric acid-gamma-lactone
-
-
2-Oxo-4-hydroxybutyric acid-gamma-lactone
-
-
2-oxoisopentanoic acid
-
-
3,4-Dihydroxy-3-cyclobutene-1,2-dione
-
uncompetitive to isatin
Ca2+
94.6% residual activity at 1 mM
Ni2+
88.5% residual activity at 1 mM
p-chloromercuribenzoate
-
-
Ag+
complete inhibition at 1 mM
Ag+
complete inhibition at 1 mM
Co2+
75.3% residual activity at 1 mM
Co2+
81.9% residual activity at 1 mM
Cu2+
29.7% residual activity at 1 mM
Cu2+
67.8% residual activity at 1 mM
EDTA
85.7% residual activity at 1 mM
Fe2+
66.8% residual activity at 1 mM
Fe2+
81% residual activity at 1 mM
ketopantoyl lactone
-
competitive to isatin
Mg2+
77.6% residual activity at 1 mM
Mg2+
80.2% residual activity at 1 mM
Mn2+
56.8% residual activity at 1 mM
Mn2+
67.6% residual activity at 1 mM
Pb2+
complete inhibition at 1 mM
Pb2+
complete inhibition at 1 mM
Polyketones
-
cyclohexenediol-1,2,3,4-tetraone; e.g. parabanic acid
-
Polyketones
-
cyclohexenediol-1,2,3,4-tetraone; e.g. parabanic acid
-
quercetin
-
-
Zn2+
10.8% residual activity at 1 mM
Zn2+
71.7% residual activity at 1 mM