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1.1.1.153: sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)

This is an abbreviated version!
For detailed information about sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming), go to the full flat file.

Word Map on EC 1.1.1.153

Reaction

L-erythro-7,8-dihydrobiopterin
+
NADP+
=
sepiapterin
+
NADPH
+
H+

Synonyms

AKR1B1, MDSPI16 protein, MDSPR, reductase, sepiapterin, sepiapterin reductase, SPR, SR

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.153 sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)

IC50 Value

IC50 Value on EC 1.1.1.153 - sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00256
(2,4-dichloro-6-hydroxyphenyl)(1,3-dihydro-2H-isoindol-2-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00012
(2,4-dichloro-6-hydroxyphenyl)(2,3-dihydro-1H-indol-1-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00244
(2,4-dichloro-6-hydroxyphenyl)(2-methyl-2,3-dihydro-1H-indol-1-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.01
(2,4-dichloro-6-hydroxyphenyl)(2-methyl-2,6-diazaspiro[3.4]octan-6-yl)methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.00168
(2,4-dichloro-6-hydroxyphenyl)(2-oxa-6-azaspiro[3.4]octan-6-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.0051
(2,4-dichloro-6-hydroxyphenyl)(3,3-dimethylpyrrolidin-1-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00021
(2,4-dichloro-6-hydroxyphenyl)(3,4-dihydroisoquinolin-2(1H)-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00068
(2,4-dichloro-6-hydroxyphenyl)(3,4-dihydroquinolin-1(2H)-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00527
(2,4-dichloro-6-hydroxyphenyl)(3-fluoro-3-methylpyrrolidin-1-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00052
(2,4-dichloro-6-hydroxyphenyl)(3-phenylpyrrolidin-1-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00024
(2,4-dichloro-6-hydroxyphenyl)(4-phenylpiperidin-1-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00199
(2,4-dichloro-6-hydroxyphenyl)(pyrrolidin-1-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.0006
(2,4-dichloro-6-hydroxyphenyl)[3-(1-methyl-1H-pyrazol-4-yl)pyrrolidin-1-yl]methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00038
(2,4-dichloro-6-hydroxyphenyl)[3-(2-phenylethyl)pyrrolidin-1-yl]methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00079
(2,4-dichloro-6-hydroxyphenyl)[3-(pyridin-2-yl)pyrrolidin-1-yl]methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00037
(2,4-dichloro-6-hydroxyphenyl)[3-(pyridin-3-yl)pyrrolidin-1-yl]methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00062
(2,4-dichloro-6-hydroxyphenyl)[3-(pyridin-4-yl)pyrrolidin-1-yl]methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00131
(2,4-dichloro-6-hydroxyphenyl)[3-(trifluoromethyl)pyrrolidin-1-yl]methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00061
(2,4-dichloro-6-hydroxyphenyl)[3-[(pyridin-3-yl)methyl]pyrrolidin-1-yl]methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00031
(2,4-dichloro-6-hydroxyphenyl)[3-[(pyridin-3-yl)oxy]pyrrolidin-1-yl]methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00055
(2,4-dichloro-6-hydroxyphenyl)[3-[(pyridin-4-yl)methyl]pyrrolidin-1-yl]methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00478
(2-azaspiro[3.4]octan-2-yl)(2,4-dichloro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.0024
(2-azaspiro[4.4]nonan-2-yl)(2,4-dichloro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00585
(2-azaspiro[4.5]decan-2-yl)(2,4-dichloro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00028
(3-anilinopyrrolidin-1-yl)(2,4-dichloro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00074
(3-benzylpyrrolidin-1-yl)(2,4-dichloro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00031
(4-benzylpiperidin-1-yl)(2,4-dichloro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00098
(5-azaspiro[2.4]heptan-5-yl)(2,4-dichloro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.000057
(6-aza-spiro[3.4]oct-6-yl)-(2,4-difluoro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00748
(6-azaspiro[3.4]octan-6-yl)(2,3-dichloro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00157
(6-azaspiro[3.4]octan-6-yl)(2,4-dichloro-3-fluoro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00058
(6-azaspiro[3.4]octan-6-yl)(2,4-dichloro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.01
(6-azaspiro[3.4]octan-6-yl)(2,4-dichloro-6-methoxyphenyl)methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.00067
(6-azaspiro[3.4]octan-6-yl)(2-chloro-4-fluoro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.01
(6-azaspiro[3.4]octan-6-yl)(2-chloro-6-hydroxy-4-methoxyphenyl)methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.01
(6-azaspiro[3.4]octan-6-yl)(2-chloro-6-hydroxy-4-methylphenyl)methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.00145
(6-azaspiro[3.4]octan-6-yl)(2-chloro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.01
(6-azaspiro[3.4]octan-6-yl)(2-fluoro-6-hydroxy-4-methylphenyl)methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.00029
(6-azaspiro[3.4]octan-6-yl)(2-fluoro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.01
(6-azaspiro[3.4]octan-6-yl)(2-hydroxypyridin-3-yl)methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.01
(6-azaspiro[3.4]octan-6-yl)(3,4-dichloro-2-hydroxyphenyl)methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.01
(6-azaspiro[3.4]octan-6-yl)(3,6-dichloro-2-hydroxyphenyl)methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.01
(6-azaspiro[3.4]octan-6-yl)(3-chloro-5-hydroxypyridin-4-yl)methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.00061
(6-azaspiro[3.4]octan-6-yl)(3-hydroxypyridin-2-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.01
(6-azaspiro[3.4]octan-6-yl)(3-hydroxypyridin-4-yl)methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.01
(6-azaspiro[3.4]octan-6-yl)(4,5-dichloro-2-hydroxyphenyl)methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.00772
(6-azaspiro[3.4]octan-6-yl)(4-chloro-2-fluoro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.01
(6-azaspiro[3.4]octan-6-yl)(4-chloro-2-hydroxy-6-methylphenyl)methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.00404
(6-azaspiro[3.4]octan-6-yl)(4-chloro-2-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.01
(6-azaspiro[3.4]octan-6-yl)(4-fluoro-2-hydroxyphenyl)methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.01
(6-azaspiro[3.4]octan-6-yl)(4-hydroxypyridin-3-yl)methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.00031
(6-azaspiro[3.4]octan-6-yl)(5-chloro-3-hydroxypyridin-2-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00035
(6-azaspiro[3.4]octan-6-yl)(5-fluoro-3-hydroxypyridin-2-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00155
(6-azaspiro[3.4]octan-6-yl)(5-hydroxypyrimidin-4-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00232
(6-azaspiro[3.4]octan-6-yl)[2-chloro-4-(dimethylamino)-6-hydroxyphenyl]methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.01
(6-azaspiro[3.4]octan-6-yl)[2-chloro-6-hydroxy-4-(trifluoromethyl)phenyl]methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.00046
(6-azaspiro[3.5]nonan-6-yl)(2,4-dichloro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.0089
1,2-naphthoquinone
Homo sapiens
-
wild-type, pH 6.7, 37°C
0.000083
2-(6-azaspiro[3.4]octane-6-sulfonyl)-3,5-dichlorophenol
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00003
2-(6-azaspiro[3.4]octane-6-sulfonyl)-3,5-difluorophenol
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.01
2-(6-azaspiro[3.4]octane-6-sulfonyl)-3-fluorophenol
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.00004
2-(6-azaspiro[3.4]octane-6-sulfonyl)-5-fluorophenol
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.01
4-(6-azaspiro[3.4]octane-6-carbonyl)-3-chloro-5-hydroxybenzamide
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.01
4-(6-azaspiro[3.4]octane-6-carbonyl)-3-chloro-5-hydroxybenzonitrile
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.014 - 0.03
6-Carboxypterin
0.0036
9,10-phenanthrenequinone
Homo sapiens
-
wild-type, pH 6.7, 37°C
0.45
acetic acid
5
alpha-ketoglutarate
Rattus norvegicus
-
slight, IC50 5 mM
0.0028
benzoquinone
Homo sapiens
-
wild-type, pH 6.7, 37°C
0.1
Cd2+
Rattus norvegicus
-
IC50 0.1 mM
0.00012 - 0.00037
Chlorpropamide
0.01
Cibacron Blue 3G-A
Rattus norvegicus
-
IC50 0.01 mM
0.0002 - 0.0006
dicoumarol
0.03
Ethacrynic acid
0.00034 - 0.00111
glibenclamide
0.00009
Hg2+
Rattus norvegicus
-
IC50 0.00009 mM
0.0081 - 0.06
indomethacin
0.0065 - 0.065
Isosepiapterin
0.1
Melatonin
Bombyx mori
-
recombinant enzyme, in 100 mM potassium phosphate buffer (pH 6.4), at 37°C
0.00037
mesalamine
Homo sapiens
pH and temperature not specified in the publication
0.0006 - 0.2
N-acetylserotonin
0.00029
N-acetylsulfapyridine
Homo sapiens
pH and temperature not specified in the publication
0.032
n-butyric acid
0.25
n-valeric acid
Equus caballus
-
IC50 0.25 mM, pH 6.5
0.6
Phenobarbital
Rattus norvegicus
-
slight, IC50 0.6 mM
0.0016
phenylquinone
Homo sapiens
-
wild-type, pH 6.7, 37°C
0.0045 - 0.3
propionic acid
1
pyrazole
Rattus norvegicus
-
slight, IC50 1 mM
0.00000149
QM385
Homo sapiens
pH and temperature not specified in the publication
0.06
rutin
0.000074
SPRi3
Homo sapiens
pH and temperature not specified in the publication
0.000019 - 0.011
sulfamethoxazole
0.000141 - 0.0194
sulfapyridine
0.0000235 - 0.00053
sulfasalazine
0.000014 - 0.00802
sulfathiazole
0.00051 - 0.00458
Tolbutamide
0.4
Zn2+
Rattus norvegicus
-
IC50 0.4 mM
0.0006
[4-(benzenesulfonyl)piperidin-1-yl](2,4-dichloro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication