1.1.1.153: sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)
This is an abbreviated version!
For detailed information about sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming), go to the full flat file.
Word Map on EC 1.1.1.153
-
1.1.1.153
-
tetrahydrobiopterin
-
bh4
-
aldo-keto
-
cyclohydrolase
-
aldose
-
neurotransmitter
-
pterins
-
dopa-responsive
-
tetrahydropterins
-
6-pyruvoyl-tetrahydropterin
-
n-acetylserotonin
-
dystonia
-
dihydropteridine
-
dihydroneopterin
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6-pyruvoyl
-
pteridine
-
neopterin
-
gtpch
-
ptges
-
gtp-cyclohydrolase
-
5-hydroxytryptophan
-
akr1b3
-
6r-5,6,7,8-tetrahydrobiopterin
-
epalrestat
-
hyperphenylalaninaemia
-
segawa
-
2,4-diamino-6-hydroxypyrimidine
-
medicine
- 1.1.1.153
- tetrahydrobiopterin
- bh4
-
aldo-keto
-
cyclohydrolase
- aldose
-
neurotransmitter
- pterins
-
dopa-responsive
- tetrahydropterins
- 6-pyruvoyl-tetrahydropterin
- n-acetylserotonin
- dystonia
- dihydropteridine
- dihydroneopterin
-
6-pyruvoyl
- pteridine
- neopterin
- gtpch
- ptges
-
gtp-cyclohydrolase
- 5-hydroxytryptophan
- akr1b3
- 6r-5,6,7,8-tetrahydrobiopterin
- epalrestat
- hyperphenylalaninaemia
-
segawa
- 2,4-diamino-6-hydroxypyrimidine
- medicine
Reaction
Synonyms
AKR1B1, MDSPI16 protein, MDSPR, reductase, sepiapterin, sepiapterin reductase, SPR, SR
ECTree
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IC50 Value
IC50 Value on EC 1.1.1.153 - sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)
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0.00256
(2,4-dichloro-6-hydroxyphenyl)(1,3-dihydro-2H-isoindol-2-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00012
(2,4-dichloro-6-hydroxyphenyl)(2,3-dihydro-1H-indol-1-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00244
(2,4-dichloro-6-hydroxyphenyl)(2-methyl-2,3-dihydro-1H-indol-1-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.01
(2,4-dichloro-6-hydroxyphenyl)(2-methyl-2,6-diazaspiro[3.4]octan-6-yl)methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.00168
(2,4-dichloro-6-hydroxyphenyl)(2-oxa-6-azaspiro[3.4]octan-6-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.0051
(2,4-dichloro-6-hydroxyphenyl)(3,3-dimethylpyrrolidin-1-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00021
(2,4-dichloro-6-hydroxyphenyl)(3,4-dihydroisoquinolin-2(1H)-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00068
(2,4-dichloro-6-hydroxyphenyl)(3,4-dihydroquinolin-1(2H)-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00527
(2,4-dichloro-6-hydroxyphenyl)(3-fluoro-3-methylpyrrolidin-1-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00052
(2,4-dichloro-6-hydroxyphenyl)(3-phenylpyrrolidin-1-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00024
(2,4-dichloro-6-hydroxyphenyl)(4-phenylpiperidin-1-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00199
(2,4-dichloro-6-hydroxyphenyl)(pyrrolidin-1-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.0006
(2,4-dichloro-6-hydroxyphenyl)[3-(1-methyl-1H-pyrazol-4-yl)pyrrolidin-1-yl]methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00038
(2,4-dichloro-6-hydroxyphenyl)[3-(2-phenylethyl)pyrrolidin-1-yl]methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00079
(2,4-dichloro-6-hydroxyphenyl)[3-(pyridin-2-yl)pyrrolidin-1-yl]methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00037
(2,4-dichloro-6-hydroxyphenyl)[3-(pyridin-3-yl)pyrrolidin-1-yl]methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00062
(2,4-dichloro-6-hydroxyphenyl)[3-(pyridin-4-yl)pyrrolidin-1-yl]methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00131
(2,4-dichloro-6-hydroxyphenyl)[3-(trifluoromethyl)pyrrolidin-1-yl]methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00061
(2,4-dichloro-6-hydroxyphenyl)[3-[(pyridin-3-yl)methyl]pyrrolidin-1-yl]methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00031
(2,4-dichloro-6-hydroxyphenyl)[3-[(pyridin-3-yl)oxy]pyrrolidin-1-yl]methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00055
(2,4-dichloro-6-hydroxyphenyl)[3-[(pyridin-4-yl)methyl]pyrrolidin-1-yl]methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00478
(2-azaspiro[3.4]octan-2-yl)(2,4-dichloro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.0024
(2-azaspiro[4.4]nonan-2-yl)(2,4-dichloro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00585
(2-azaspiro[4.5]decan-2-yl)(2,4-dichloro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00028
(3-anilinopyrrolidin-1-yl)(2,4-dichloro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00074
(3-benzylpyrrolidin-1-yl)(2,4-dichloro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00031
(4-benzylpiperidin-1-yl)(2,4-dichloro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00098
(5-azaspiro[2.4]heptan-5-yl)(2,4-dichloro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.000057
(6-aza-spiro[3.4]oct-6-yl)-(2,4-difluoro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00748
(6-azaspiro[3.4]octan-6-yl)(2,3-dichloro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00157
(6-azaspiro[3.4]octan-6-yl)(2,4-dichloro-3-fluoro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00058
(6-azaspiro[3.4]octan-6-yl)(2,4-dichloro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.01
(6-azaspiro[3.4]octan-6-yl)(2,4-dichloro-6-methoxyphenyl)methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.00067
(6-azaspiro[3.4]octan-6-yl)(2-chloro-4-fluoro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.01
(6-azaspiro[3.4]octan-6-yl)(2-chloro-6-hydroxy-4-methoxyphenyl)methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.01
(6-azaspiro[3.4]octan-6-yl)(2-chloro-6-hydroxy-4-methylphenyl)methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.00145
(6-azaspiro[3.4]octan-6-yl)(2-chloro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.01
(6-azaspiro[3.4]octan-6-yl)(2-fluoro-6-hydroxy-4-methylphenyl)methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.00029
(6-azaspiro[3.4]octan-6-yl)(2-fluoro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.01
(6-azaspiro[3.4]octan-6-yl)(2-hydroxypyridin-3-yl)methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.01
(6-azaspiro[3.4]octan-6-yl)(3,4-dichloro-2-hydroxyphenyl)methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.01
(6-azaspiro[3.4]octan-6-yl)(3,6-dichloro-2-hydroxyphenyl)methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.01
(6-azaspiro[3.4]octan-6-yl)(3-chloro-5-hydroxypyridin-4-yl)methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.00061
(6-azaspiro[3.4]octan-6-yl)(3-hydroxypyridin-2-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.01
(6-azaspiro[3.4]octan-6-yl)(3-hydroxypyridin-4-yl)methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.01
(6-azaspiro[3.4]octan-6-yl)(4,5-dichloro-2-hydroxyphenyl)methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.00772
(6-azaspiro[3.4]octan-6-yl)(4-chloro-2-fluoro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.01
(6-azaspiro[3.4]octan-6-yl)(4-chloro-2-hydroxy-6-methylphenyl)methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.00404
(6-azaspiro[3.4]octan-6-yl)(4-chloro-2-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.01
(6-azaspiro[3.4]octan-6-yl)(4-fluoro-2-hydroxyphenyl)methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.01
(6-azaspiro[3.4]octan-6-yl)(4-hydroxypyridin-3-yl)methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.00031
(6-azaspiro[3.4]octan-6-yl)(5-chloro-3-hydroxypyridin-2-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00035
(6-azaspiro[3.4]octan-6-yl)(5-fluoro-3-hydroxypyridin-2-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00155
(6-azaspiro[3.4]octan-6-yl)(5-hydroxypyrimidin-4-yl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00232
(6-azaspiro[3.4]octan-6-yl)[2-chloro-4-(dimethylamino)-6-hydroxyphenyl]methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.01
(6-azaspiro[3.4]octan-6-yl)[2-chloro-6-hydroxy-4-(trifluoromethyl)phenyl]methanone
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.00046
(6-azaspiro[3.5]nonan-6-yl)(2,4-dichloro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.000083
2-(6-azaspiro[3.4]octane-6-sulfonyl)-3,5-dichlorophenol
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00003
2-(6-azaspiro[3.4]octane-6-sulfonyl)-3,5-difluorophenol
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.01
2-(6-azaspiro[3.4]octane-6-sulfonyl)-3-fluorophenol
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.00004
2-(6-azaspiro[3.4]octane-6-sulfonyl)-5-fluorophenol
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.01
4-(6-azaspiro[3.4]octane-6-carbonyl)-3-chloro-5-hydroxybenzamide
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.01
4-(6-azaspiro[3.4]octane-6-carbonyl)-3-chloro-5-hydroxybenzonitrile
Homo sapiens
IC50 above 0.01 mM, at pH 7.4, temperature not specified in the publication
0.1
Melatonin
Bombyx mori
-
recombinant enzyme, in 100 mM potassium phosphate buffer (pH 6.4), at 37°C
0.00029
N-acetylsulfapyridine
Homo sapiens
pH and temperature not specified in the publication
0.0006
[4-(benzenesulfonyl)piperidin-1-yl](2,4-dichloro-6-hydroxyphenyl)methanone
Homo sapiens
at pH 7.4, temperature not specified in the publication
0.00012
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.0006
N-acetylserotonin
Homo sapiens
pH and temperature not specified in the publication
0.2
N-acetylserotonin
Bombyx mori
-
recombinant enzyme, in 100 mM potassium phosphate buffer (pH 6.4), at 37°C
0.000019
Homo sapiens
pH and temperature not specified in the publication
0.00018
sulfamethoxazole
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.000141
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.00048
sulfapyridine
Homo sapiens
pH and temperature not specified in the publication
0.0000235
Homo sapiens
pH and temperature not specified in the publication
0.000031
sulfasalazine
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.000014
Homo sapiens
pH and temperature not specified in the publication
0.000062
sulfathiazole
Homo sapiens
pH not specified in the publication, temperature not specified in the publication