1.1.1.141: 15-hydroxyprostaglandin dehydrogenase (NAD+)

This is an abbreviated version!
For detailed information about 15-hydroxyprostaglandin dehydrogenase (NAD+), go to the full flat file.

Reaction

Synonyms

11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase, 15-hydroxy prostaglandin dehydrogenase, 15-hydroxy-prostaglandin-dehydrogenase, 15-hydroxyprostaglandin dehydrogenase, 15-hydroxyprostaglandin-dehydrogenase, 15-hydroxyprostanoic dehydrogenase, 15-OH-PGDH, 15-PGDH, 15-prostaglandin dehydrogenase, dehydrogenase, 15-hydroxyprostaglandin, HPGD, NAD+ dependent 15-hydroxyprostaglandin dehydrogenase, NAD+ dependent PGDH, NAD+-15-hydroxy prostanoate oxidoreductase, NAD+-dependent 15-hydroxyprostaglandin dehydrogenase, NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (type I), NAD+-dependent 15-PGDH, NAD+-linked 15-hydroxyprostaglandin dehydrogenase, NAD-dependent 15-hydroxyprostaglandin dehydrogenase, NAD-specific 15-hydroxyprostaglandin dehydrogenase, nicotinamide adenine dinucleotide-dependent 15-hydroxyprostaglandin dehydrogenase, PGDH, prostaglandin dehydrogenase

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.141 15-hydroxyprostaglandin dehydrogenase (NAD+)

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Results	in table
30	Activating Compound
43	AA Sequence
9	Application
1	CAS Registry Number
23	Cloned(Commentary)
62	Cofactor
1	Crystallization (Commentary)
1263	Disease/ Diagnostics
11	Expression
9	General Information
7	General Stability
108	IC50 Value
268	Inhibitors
7	kcat/KM [mM/s]
38	Ki Value [mM]
100	KM Value [mM]
8	Localization
19	Molecular Weight [Da]
51	Natural Substrates/ Products (Substrates)
164	Organism
6	Pathway
1	PDB ID
19	pH Optimum
2	pH Range
70	Protein Variants
34	Purification (Commentary)
9	Reaction
3	Reaction Type
101	Reference
226	Source Tissue
24	Specific Activity [micromol/min/mg]
8	Storage Stability
175	Substrates and Products (Substrate)
14	Subunits
121	Synonyms
1	Systematic Name
13	Temperature Optimum [°C]
4	Temperature Stability [°C]
25	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 1.1.1.141 - 15-hydroxyprostaglandin dehydrogenase (NAD+)

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

44 entries

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

Homo sapiens

-

-

667147

i.e. 15-hydroxyprostaglandin or (15S)-PGE2

-

r

(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

5 entries

(5Z,8E,10E,12S)-12-hydroxy-5,8,10-heptadecatrienoic acid + NAD+

(5Z,8E,10E)-12-oxo-5,8,10-heptadecatrienoic acid + NADH

3 entries

11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+

11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH

16 entries

15(S)-hydroperoxy-5,8,11,13-(Z,Z,Z,E)-eicosatetraenoic acid + NAD+

15-oxo-5,8,11,13-(Z,Z,Z,E)-eicosatetraenoic acid + NADH

Homo sapiens

-

-

700302

-

-

?

15-hydroxyeicosatetraenoic acid + NAD+

15-ketoeicosatetraenoic acid + NADH

Oryctolagus cuniculus

-

-

285938

-

285938

?

15-hydroxyprostaglandin + NAD+

15-oxoprostaglandin + NADH + H+

4 entries

19-hydroxyprostaglandin E1 + NAD+

19-hydroxy-15-oxoprostaglandin E1 + NADH

Oryctolagus cuniculus

-

-

285938

-

285938

?

20-hydroxyprostaglandin E1 + NAD+

20-hydroxy-15-ketoprostaglandin E1 + NADH

Oryctolagus cuniculus

-

-

285938

-

285938

?

5,6-chrysenequinone + NADH

?

Homo sapiens

-

-

285932

-

-

?

5,6-chrysenequinone + NADH

? + H2O2

Homo sapiens

-

formation of potentially hazardous semiquinones, reaction mechanism, overview

285932

-

-

?

6-keto-prostaglandin E1 + NAD+

? + NADH

Oryctolagus cuniculus

-

-

285921

-

-

?

6-keto-prostaglandin F1alpha + NAD+

? + NADH

Oryctolagus cuniculus

-

-

285921

-

-

?

6-ketoprostaglandin E1 + NAD+

6,15-diketoprostaglandin E1

Oryctolagus cuniculus

-

-

285921

-

285921

?

6-ketoprostaglandin F1alpha + NAD+

6,15-diketoprostaglandin F1alpha + NADH + H+

2 entries

9,10-phenanthrenequinone + NADH

?

Homo sapiens

-

-

285932

-

-

?

9,10-phenanthrenequinone + NADH

? + H2O2

Homo sapiens

-

formation of potentially hazardous semiquinones, reaction mechanism, overview

285932

-

-

?

prostaglandin A1 + NAD+

15-ketoprostaglandin A1 + NADH + H+

7 entries

prostaglandin A1 + NAD+

? + NADH

Oryctolagus cuniculus

-

-

285921

-

-

?

prostaglandin A2 + NAD+

15-ketoprostaglandin A2 + NADH + H+

2 entries

prostaglandin D1 + NAD+

15-ketoprostaglandin D1 + NADH + H+

Homo sapiens

-

very low activity

285923

-

285923

?

prostaglandin D2 + NAD+

15-ketoprostaglandin D2 + NADH + H+

2 entries

prostaglandin D2 + NAD+

? + NADH

Oryctolagus cuniculus

-

-

285921

-

-

?

prostaglandin E1 + NAD+

15-ketoprostaglandin E1 + NADH + H+

Homo sapiens

-

-

285916, 285920, 285923, 285927, 285937, 697090

-

-

?

prostaglandin E1 + NAD+

15-oxoprostaglandin E1 + NADH + H+

Bos taurus

-

-

285926

-

-

r

prostaglandin E1 + NAD+

? + NADH

Oryctolagus cuniculus

-

-

285921, 285938

-

-

?

prostaglandin E2 + NAD+

15-ketoprostaglandin E2 + NADH + H+

3 entries

prostaglandin E2 + NAD+

15-oxoprostaglandin E2 + NADH + H+

9 entries

prostaglandin E3 + NAD+

15-keto-prostaglandin E3 + NADH + H+

Oryctolagus cuniculus

-

-

285938

-

285938

?

prostaglandin F2alpha + NAD+

15-ketoprostaglandin F2alpha + NADH + H+

13 entries

prostaglandin F2alpha + NAD+

15-oxoprostaglandin F2alpha + NADH + H+

Canis lupus familiaris

E2QX67

-

740130

-

-

?

prostaglandin F2alpha + NAD+

? + NADH

Oryctolagus cuniculus

-

-

285921

-

-

?

prostaglandin I2 + NAD+

15-ketoprostaglandin I2 + NADH + H+

Homo sapiens

-

-

285923

-

285923

?

additional information

?

-

10 entries

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Bos taurus

-

-

285917, 285926

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Bos taurus

Q309F3

-

670868

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Bos taurus

-

i.e. 15-hydroxyprostaglandin or (15S)-PGE2

285917

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Bos taurus

Q309F3

i.e. 15-hydroxyprostaglandin or (15S)-PGE2

670868

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Canis lupus familiaris

-

first step in prostaglandin catabolism

285918

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Canis lupus familiaris

-

i.e. 15-hydroxyprostaglandin or (15S)-PGE2

285918

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Cavia porcellus

-

first step in prostaglandin catabolism

285918

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Cavia porcellus

-

i.e. 15-hydroxyprostaglandin or (15S)-PGE2

285918

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Homo sapiens

-

-

285919

-

285919

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Homo sapiens

-

-

285927

-

285927

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Homo sapiens

-

-

285931

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Homo sapiens

-

-

285938

-

285938

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Homo sapiens

-

-

654158, 654348, 654361, 654374, 654380, 657209, 667924, 668172, 711448

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Homo sapiens

-

-

657210

-

-

r

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Homo sapiens

P15428

-

686593

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Homo sapiens

-

i.e. prostaglandin E1

285923

-

285923

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Homo sapiens

-

i.e. prostaglandin E1

285915

i.e. 15-ketoprostaglandin E1

285915

r

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Homo sapiens

-

catabolism of (15S)-PGE2

668162

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Homo sapiens

-

first step in prostaglandin catabolism

285932

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Homo sapiens

-

first step in prostaglnadin catabolism

285916

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Homo sapiens

-

i.e. 15-hydroxyprostaglandin or (15S)-PGE2

285916, 285931, 285932, 285939, 667558, 668160, 668162, 668172, 668173, 670734

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Homo sapiens

-

key step in prostaglandin catabolism, enzyme activation leads to reduced cell proliferation, the enzyme is an antagonist of ibuprofen

670734

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Homo sapiens

-

key step in prostaglandin inactivation

285939

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Homo sapiens

-

PGE2 degradation

669380

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Homo sapiens

-

prostaglandin E2, PGE2, a proinflammatory bioactive lipid, promotes cancer progression by modulating proliferation, apoptosis, and angiogenesis, PGE2 is a downstream product cyclooxygenase and is biochemically inactivated by the enzyme

668160

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Homo sapiens

-

reciprocal regulation of cyclooxygenase-2 and 15-hydroxyprostaglandin dehydrogenase expression in A549 human lung adenocarcinoma cells, overview

668173

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Homo sapiens

-

the enzyme is a putative cyclooxygenase-2 antagonist and and tumor suppressor

667558

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Homo sapiens

-

transcriptional regulation and biological functions, the enzyme cooperates with cyclooxygenase-2 to control cellular prostaglandin levels, reciprocal regulation of the two enzymes, overview

668359

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Homo sapiens

-

i.e. 15-hydroxyprostaglandin or (15S)-PGE2, inactivation

668359

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Homo sapiens

-

i.e. 15-hydroxyprostaglandin or (15S)-PGE2, substrate binding structure analysis, determination of interactions

667924

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Homo sapiens

-

i.e. 15-hydroxyprostaglandin or PGE2

669380

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Macaca fascicularis

-

-

348015

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Mus musculus

-

i.e. 15-hydroxyprostaglandin or (15S)-PGE2

670691

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Mus musculus

-

PGE2 degradation

669380

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Mus musculus

-

i.e. 15-hydroxyprostaglandin or PGE2

669380

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Mus musculus C57/BL6J

-

i.e. 15-hydroxyprostaglandin or (15S)-PGE2

670691

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Oryctolagus cuniculus

-

-

285921, 285938

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Oryctolagus cuniculus

-

first step in prostaglandin catabolism

285921

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Oryctolagus cuniculus

-

i.e. 15-hydroxyprostaglandin or (15S)-PGE2, best substrate

285921

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Rattus norvegicus

-

first step in prostaglandin catabolism

285918

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Rattus norvegicus

-

i.e. 15-hydroxyprostaglandin or (15S)-PGE2

285918

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Sus scrofa

-

-

285924

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Sus scrofa

-

first step in prostaglandin catabolism

285918

-

-

?

(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Sus scrofa

-

i.e. 15-hydroxyprostaglandin or (15S)-PGE2

285918

-

-

?

(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Homo sapiens

P15428

-

741244, 762674

-

-

?

(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Homo sapiens

-

-

762674

-

-

?

(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Mus musculus

Q8VCC1

-

763614

-

-

?

(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Mus musculus

Q8VCC1

the enzyme catalyzes the oxidation of the 15(S)-hydroxyl group of prostaglandin E2 (PGE2), converting the proinflammatory PGE2 to the anti-inflammatory 15-keto-PGE2 (an endogenous ligand for peroxisome proliferator-activated receptor-gamma [PPAR-gamma])

763614

-

-

?

(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+

(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+

Rattus norvegicus

-

-

739837

-

-

?

(5Z,8E,10E,12S)-12-hydroxy-5,8,10-heptadecatrienoic acid + NAD+

(5Z,8E,10E)-12-oxo-5,8,10-heptadecatrienoic acid + NADH

Homo sapiens

-

-

285935

-

285935

?

(5Z,8E,10E,12S)-12-hydroxy-5,8,10-heptadecatrienoic acid + NAD+

(5Z,8E,10E)-12-oxo-5,8,10-heptadecatrienoic acid + NADH

Homo sapiens

-

-

285938

-

285938

?

(5Z,8E,10E,12S)-12-hydroxy-5,8,10-heptadecatrienoic acid + NAD+

(5Z,8E,10E)-12-oxo-5,8,10-heptadecatrienoic acid + NADH

Oryctolagus cuniculus

-

-

285938

-

-

?

11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+

11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH

Bos taurus

-

-

285917

-

285917

?

11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+

11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH

Bos taurus

-

-

285938

-

285938

?

11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+

11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH

Canis lupus familiaris

-

-

285912

-

285912

?

11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+

11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH

Gallus gallus

-

NAD+ is much more effective than NADP+

285912

-

285912

?

11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+

11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH

Homo sapiens

-

-

285912

-

285912

?

11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+

11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH

Homo sapiens

-

-

285919

-

285919

?

11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+

11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH

Homo sapiens

-

-

285927

-

285927

?

11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+

11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH

Homo sapiens

-

-

285938

-

285938

?

11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+

11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH

Homo sapiens

-

specific for NAD+

285915

-

285915

?

11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+

11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH

Homo sapiens

-

specific for NAD+

285923

-

285923

?

11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+

11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH

Oryctolagus cuniculus

-

-

285938

-

285938

?

11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+

11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH

Oryctolagus cuniculus

-

specific for NAD+

285921

-

285921

?

11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+

11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH

Platyrrhini

-

NADP+ is more effective than NAD+

285912

-

285912

?

11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+

11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH

Sus scrofa

-

-

285912

-

285912

?

11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+

11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH

Sus scrofa

-

-

285924

-

285924

?

11alpha,15(S)-dihydroxy-9-ketoprost-5,13-dienoic acid + NAD(P)+

11alpha-hydroxy-9,15-diketoprost-5,13-dienoic acid + NADH

Sus scrofa

-

-

285938

-

285938

?

15-hydroxyprostaglandin + NAD+

15-oxoprostaglandin + NADH + H+

Homo sapiens

-

-

685958, 695481, 695883, 724920

-

-

?

15-hydroxyprostaglandin + NAD+

15-oxoprostaglandin + NADH + H+

Homo sapiens

-

physiological inactivation of prostaglandin by catalyzing the first step in catabolism

285914

-

285914

?

15-hydroxyprostaglandin + NAD+

15-oxoprostaglandin + NADH + H+

Homo sapiens

-

physiological inactivation of prostaglandin by catalyzing the first step in catabolism

285923

-

285923

?

15-hydroxyprostaglandin + NAD+

15-oxoprostaglandin + NADH + H+

Homo sapiens

-

physiological inactivation of prostaglandin by catalyzing the first step in catabolism

285927

-

285927

?

6-ketoprostaglandin F1alpha + NAD+

6,15-diketoprostaglandin F1alpha + NADH + H+

Homo sapiens

-

-

285923

-

285923

?

6-ketoprostaglandin F1alpha + NAD+

6,15-diketoprostaglandin F1alpha + NADH + H+

Oryctolagus cuniculus

-

-

285921

-

285921

?

prostaglandin A1 + NAD+

15-ketoprostaglandin A1 + NADH + H+

Homo sapiens

-

-

285915

-

285915

?

prostaglandin A1 + NAD+

15-ketoprostaglandin A1 + NADH + H+

Homo sapiens

-

-

285923

-

285923

?

prostaglandin A1 + NAD+

15-ketoprostaglandin A1 + NADH + H+

Homo sapiens

-

-

285927

-

285927

?

prostaglandin A1 + NAD+

15-ketoprostaglandin A1 + NADH + H+

Homo sapiens

-

-

285937

-

-

?

prostaglandin A1 + NAD+

15-ketoprostaglandin A1 + NADH + H+

Homo sapiens

-

-

285938

-

285938

?

prostaglandin A1 + NAD+

15-ketoprostaglandin A1 + NADH + H+

Oryctolagus cuniculus

-

-

285921

-

285921

?

prostaglandin A1 + NAD+

15-ketoprostaglandin A1 + NADH + H+

Oryctolagus cuniculus

-

-

285938

-

285938

?

prostaglandin A2 + NAD+

15-ketoprostaglandin A2 + NADH + H+

Homo sapiens

-

-

285927

-

285927

?

prostaglandin A2 + NAD+

15-ketoprostaglandin A2 + NADH + H+

Homo sapiens

-

-

285937

-

-

?

prostaglandin D2 + NAD+

15-ketoprostaglandin D2 + NADH + H+

Oryctolagus cuniculus

-

-

285921

-

285921

?

prostaglandin D2 + NAD+

15-ketoprostaglandin D2 + NADH + H+

Oryctolagus cuniculus

-

-

285938

-

285938

?

prostaglandin E2 + NAD+

15-ketoprostaglandin E2 + NADH + H+

Homo sapiens

-

-

285916, 695481, 695883, 697090

-

-

?

prostaglandin E2 + NAD+

15-ketoprostaglandin E2 + NADH + H+

Homo sapiens

-

the wild type enzyme is highly active against prostaglandin E2 and NAD+

689129

-

-

?

prostaglandin E2 + NAD+

15-ketoprostaglandin E2 + NADH + H+

Rattus norvegicus

O08699

-

688932

-

-

?

prostaglandin E2 + NAD+

15-oxoprostaglandin E2 + NADH + H+

Canis lupus familiaris

E2QX67

-

740130

-

-

?

prostaglandin E2 + NAD+

15-oxoprostaglandin E2 + NADH + H+

Gallus gallus

-

-

285912

-

-

r

prostaglandin E2 + NAD+

15-oxoprostaglandin E2 + NADH + H+

Homo sapiens

-

-

725664, 726267

-

-

?

prostaglandin E2 + NAD+

15-oxoprostaglandin E2 + NADH + H+

Homo sapiens

P15428

-

740148, 740159, 740536

-

-

?

prostaglandin E2 + NAD+

15-oxoprostaglandin E2 + NADH + H+

Homo sapiens

-

-

740536

-

-

?

prostaglandin E2 + NAD+

15-oxoprostaglandin E2 + NADH + H+

Homo sapiens

P15428

-

740709, 741014

-

-

?

prostaglandin E2 + NAD+

15-oxoprostaglandin E2 + NADH + H+

Homo sapiens

-

-

741014

-

-

?

prostaglandin E2 + NAD+

15-oxoprostaglandin E2 + NADH + H+

Homo sapiens

P15428

-

741035, 741244

-

-

?

prostaglandin E2 + NAD+

15-oxoprostaglandin E2 + NADH + H+

Homo sapiens

-

-

741244

-

-

?

prostaglandin F2alpha + NAD+

15-ketoprostaglandin F2alpha + NADH + H+

Canis lupus familiaris

-

-

285912

-

285912

?

prostaglandin F2alpha + NAD+

15-ketoprostaglandin F2alpha + NADH + H+

Gallus gallus

-

NAD+ is much more effective than NADP+

285912

-

285912

?

prostaglandin F2alpha + NAD+

15-ketoprostaglandin F2alpha + NADH + H+

Homo sapiens

-

-

285912

-

285912

?

prostaglandin F2alpha + NAD+

15-ketoprostaglandin F2alpha + NADH + H+

Homo sapiens

-

-

285919

-

285919

?

prostaglandin F2alpha + NAD+

15-ketoprostaglandin F2alpha + NADH + H+

Homo sapiens

-

-

285938

-

285938

?

prostaglandin F2alpha + NAD+

15-ketoprostaglandin F2alpha + NADH + H+

Homo sapiens

-

-

697090

-

-

?

prostaglandin F2alpha + NAD+

15-ketoprostaglandin F2alpha + NADH + H+

Homo sapiens

-

specific for NAD+

285915

-

285915

?

prostaglandin F2alpha + NAD+

15-ketoprostaglandin F2alpha + NADH + H+

Homo sapiens

-

specific for NAD+

285923

-

285923

?

prostaglandin F2alpha + NAD+

15-ketoprostaglandin F2alpha + NADH + H+

Oryctolagus cuniculus

-

-

285938

-

285938

?

prostaglandin F2alpha + NAD+

15-ketoprostaglandin F2alpha + NADH + H+

Oryctolagus cuniculus

-

specific for NAD+

285921

-

285921

?

prostaglandin F2alpha + NAD+

15-ketoprostaglandin F2alpha + NADH + H+

Platyrrhini

-

NADP+ is more effective than NAD+

285912

-

285912

?

prostaglandin F2alpha + NAD+

15-ketoprostaglandin F2alpha + NADH + H+

Sus scrofa

-

-

285912

-

285912

?

prostaglandin F2alpha + NAD+

15-ketoprostaglandin F2alpha + NADH + H+

Sus scrofa

-

-

285938

-

285938

?

additional information

?

-

Bos taurus

-

the enzyme catalyzes specifically the oxidation of the (15S)-hydroxy group of all natural prostaglandins except the B and 19-hydroxylated types

285917

-

-

?

additional information

?

-

Homo sapiens

-

dexamethasone and phorbol ester play a role in enzyme regulation in erythroleukemia cells

285931

-

-

?

additional information

?

-

Homo sapiens

-

key enzyme for metabolic inactivation of prostaglandins, enzyme levels are reduced in inflammatory bowel disease involving TNF-alpha

667147

-

-

?

additional information

?

-

Homo sapiens

-

the enzyme is a tumor suppressor of human breast cancer, expression of the enzyme and the estrogen receptor is correlated, silencing of the enzyme results in enhanced cancer cell proliferation, the enzyme expression is silenced in vivo in cancer cells due to promoter methylation

668162

-

-

?

additional information

?

-

Homo sapiens

-

the enzyme is involved in anti-proliferative effect of non-steroidal anti-inflammatory drugs COX-1 inhibitors on a medullary thyroid carcinoma cell line

670734

-

-

?

additional information

?

-

Homo sapiens

-

15-hydroxyprostaglandin dehydrogenase may be repressed by an epigenetic mechanism involving histone deacetylation, resulting in increased prostaglandin E2 activity in tumors

685947

-

-

?

additional information

?

-

Macaca mulatta

-

prostaglandins play an essential role in primate parturition acting on uterine contractility and on cervical ripening

670524

-

-

?

additional information

?

-

Mus musculus

-

the enzyme is an in vivo suppressor of colon tumorigenesis, mechanism of conferring increased susceptibility to colon neoplasia, overview

670691

-

-

?

additional information

?

-

Mus musculus C57/BL6J

-

the enzyme is an in vivo suppressor of colon tumorigenesis, mechanism of conferring increased susceptibility to colon neoplasia, overview

670691

-

-

?

additional information

?

-

Oryctolagus cuniculus

-

substrate specificity, overview, no activity with prostaglandin B1

285921

-

-

?