1.1.1.132: GDP-mannose 6-dehydrogenase
This is an abbreviated version!
For detailed information about GDP-mannose 6-dehydrogenase, go to the full flat file.
Word Map on EC 1.1.1.132
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1.1.1.132
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aeruginosa
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alginate
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cystic
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fibrosis
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mucoid
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mannuronic
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midecamycin
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sputum
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vinelandii
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molecular-genetic
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azotobacter
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erythromycin
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macrolide
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elastase
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chemoenzymatic
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gdpmannose
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multidrug-resistant
- 1.1.1.132
- aeruginosa
- alginate
-
cystic
- fibrosis
- mucoid
-
mannuronic
- midecamycin
-
sputum
- vinelandii
-
molecular-genetic
-
azotobacter
- erythromycin
-
macrolide
- elastase
-
chemoenzymatic
- gdpmannose
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multidrug-resistant
Reaction
Synonyms
algD, GDP mannose dehydrogenase, GDP-D-mannose dehydrogenase, GDP-mannose dehydrogenase, GMD, GMD1, GMD2, guanosine diphosphate mannose dehydrogenase, guanosine diphospho-D-mannose dehydrogenase, guanosine diphosphomannose dehydrogenase
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Substrates Products
Substrates Products on EC 1.1.1.132 - GDP-mannose 6-dehydrogenase
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REACTION DIAGRAM
deoxy-GDP-D-mannuronate + 2 NADH + 2 H+
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Deoxy-GDP-D-mannose + 2 NAD+ + H2O
deoxy-GDP-D-mannuronate + 2 NADH + 2 H+
Arthrobacter sp. NRRL B1973
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deoxy-GDP-D-mannose + NAD+ + H2O
deoxy-GDP-D-mannuronate + NADH
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deoxy-GDP-D-mannose + NAD+ + H2O
deoxy-GDP-D-mannuronate + NADH
Arthrobacter sp. NRRL B1973
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GDP-D-mannuronate + 2 NADH + 2 H+
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GDP-D-mannose + 2 NAD+ + H2O
GDP-D-mannuronate + 2 NADH + 2 H+
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GDP-D-mannose + NAD+ + H2O
GDP-D-mannunorate + NADH
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the enzyme catalyzes the first committed step in alginate biosynthesis
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GDP-mannose + NAD+ + H2O
GDP-mannuronate + NADH
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water-soluble and insoluble polysaccharides are produced, containing glucuronic and mannuronic acid, glucose and rhamnose, GDP-D-mannose dehydrogenase activity detected in 30 h cultures and 36 h cultures containing only water-insoluble capsular or water-soluble polysaccharides, respectively
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key enzyme in alginate biosynthesis
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additional information
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no substrate: D-mannose, UDP-D-mannose, UDP-D-glucose, TDP-D-glucose, CDP-D-glucose
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additional information
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GMD is the key enzyme in alginate biosynthesis. Biofilm-forming bacteria Pseudomonas aeruginosa is a common pathogen in mechanically ventilated newborns, which can cause life-threatening infections
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additional information
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GMD is the key enzyme in alginate biosynthesis. Biofilm-forming bacteria Pseudomonas aeruginosa is a common pathogen in mechanically ventilated newborns, which can cause life-threatening infections
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additional information
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algD is localized in an alginate biosynthesis cluster
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