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1.1.1.12: L-arabinitol 4-dehydrogenase

This is an abbreviated version!
For detailed information about L-arabinitol 4-dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.12

Reaction

L-arabinitol
+
NAD+
=
L-xylulose
+
NADH
+
H+

Synonyms

ADH, dehydrogenase, L-arabinitol, HjLAD, L-arabinitol dehydrogenase, L-arabitol dehydrogenase, LAD, Lad1, LADA, More, NAD(P)+-dependent arabitol dehydrogenase, pentitol-DPN dehydrogenase, XYL2

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.12 L-arabinitol 4-dehydrogenase

Engineering

Engineering on EC 1.1.1.12 - L-arabinitol 4-dehydrogenase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D213S/I214R
significantly higher preference for NADP+ over NAD+
Y318F
D211S
strong decrease in activity
D211S/I212R
strong decrease in activity, increase in activity with cofactor NADP+
D211S/I212R/D213N
strong decrease in activity, increase in activity with cofactor NADP+
D211S/I212R/S348T
strong decrease in activity, increase in activity with cofactor NADP+
D212S/I213R
D224S/I225R
significantly altered cofactor specificity from NAD+ to NADP+
additional information