Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.1.1.102: 3-dehydrosphinganine reductase

This is an abbreviated version!
For detailed information about 3-dehydrosphinganine reductase, go to the full flat file.

Word Map on EC 1.1.1.102

Reaction

sphinganine
+
NADP+
=
3-dehydrosphinganine
+
NADPH
+
H+

Synonyms

3-KDS reductase, 3-ketodihydrosphingosine reductase, 3-ketosphinganine reductase, 3-oxosphinganine reductase, 3-oxosphinganine:NADPH oxidoreductase, 3KDSR, D-3-dehydrosphinganine reductase, D-3-oxosphinganine reductase, D-3-oxosphinganine:B-NADPH oxidoreductase, DSR, FVT-1, Fvt1, h-FTV-1, KDS reductase, Ksr1p, KsrA, m-FTV-1, More, TSC10, TSC10A, Tsc10p

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.102 3-dehydrosphinganine reductase

Reference

Reference on EC 1.1.1.102 - 3-dehydrosphinganine reductase

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Beeler, T.; Bacikova, D.; Gable, K.; Hopkins, L.; Johnson, C.; Slife, H.; Dunn, T.
The Saccharomyces cerevisiae TSC10/BR265w gene encoding 3-ketosphinganine reductase is identified in a screen for temperature-sensitive suppressors of the Ca2+-sensitive csg2delta mutant
J. Biol. Chem.
273
30688-30694
1998
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Mandon, E.C.; Ehses, I.; Rother, J.; van Echten, G.; Sandhoff, K.
Subcellular localization and membrane topology of serine palmitoyltransferase, 3-dehydrosphinganine reductase, and sphinganine N-acyltransferase in mouse liver
J. Biol. Chem.
267
11144-11148
1992
Mus musculus
Manually annotated by BRENDA team
Stoffel, W.; LeKim, D.; Sticht, G.
Stereospecificity of the NADPH-dependent reduction reaction of 3-oxodihydrosphingosine (2-amino-1-hydroxyoctadecane-3-one)
Hoppe-Seyler's Z. Physiol. Chem.
349
1637-1644
1968
Bos taurus, Rattus norvegicus
Manually annotated by BRENDA team
Stoffel, W.; LeKim, D.; Sticht, G.
Biosynthesis of dihydrosphingosine in vitro
Hoppe-Seyler's Z. Physiol. Chem.
349
664-670
1968
Wickerhamomyces ciferrii, Rattus norvegicus
Manually annotated by BRENDA team
Kihara, A.; Igarashi, Y.
FVT-1 is a mammalian 3-ketodihydrosphingosine reductase with an active site that faces the cytosolic side of the endoplasmic reticulum membrane
J. Biol. Chem.
279
49243-49250
2004
Homo sapiens (Q06136), Homo sapiens, Mus musculus (Q6GV12), Mus musculus
Manually annotated by BRENDA team
Fornarotto, M.; Xiao, L.; Hou, Y.; Koch, K.A.; Chang, E.; OMalley, R.M.; Black, T.A.; Cable, M.B.; Walker, S.S.
Sphingolipid biosynthesis in pathogenic fungi: identification and characterization of the 3-ketosphinganine reductase activity of Candida albicans and Aspergillus fumigatus
Biochim. Biophys. Acta
1761
52-63
2006
Aspergillus fumigatus, Saccharomyces cerevisiae, Candida albicans
Manually annotated by BRENDA team
Krebs, S.; Medugorac, I.; Roether, S.; Straesser, K.; Foerster, M.
A missense mutation in the 3-ketodihydrosphingosine reductase FVT1 as candidate causal mutation for bovine spinal muscular atrophy
Proc. Natl. Acad. Sci. USA
104
6746-6751
2007
Bos taurus (Q2KIJ5), Bos taurus
Manually annotated by BRENDA team
Gupta, S.D.; Gable, K.; Han, G.; Borovitskaya, A.; Selby, L.; Dunn, T.M.; Harmon, J.M.
Tsc10p and FVT1: Topologically distinct short-chain reductases required for long-chain base synthesis in yeast and mammals
J. Lipid Res.
50
1630-1640
2009
Saccharomyces cerevisiae, Homo sapiens
Manually annotated by BRENDA team
Kim, S.; Noh, Y.; Koo, J.; Da Silva, N.; Yun, H.
Effects of expression of lcb1/lcb2 and lac1/lag1 genes on the biosynthesis of ceramides
Biotechnol. Bioprocess Eng.
16
1-6
2011
Saccharomyces cerevisiae, Saccharomyces cerevisiae KCCM 50515
-
Manually annotated by BRENDA team
Timmins-Schiffman, E.; Roberts, S.
Characterization of genes involved in ceramide metabolism in the Pacific oyster (Crassostrea gigas)
BMC Res. Notes
5
502
2012
Crassostrea gigas ( S4SCP5), Crassostrea gigas
Manually annotated by BRENDA team
Chao, D.Y.; Gable, K.; Chen, M.; Baxter, I.; Dietrich, C.R.; Cahoon, E.B.; Guerinot, M.L.; Lahner, B.; Lue, S.; Markham, J.E.; Morrissey, J.; Han, G.; Gupta, S.D.; Harmon, J.M.; Jaworski, J.G.; Dunn, T.M.; Salt, D.E.
Sphingolipids in the root play an important role in regulating the leaf ionome in Arabidopsis thaliana
Plant Cell
23
1061-1081
2011
Arabidopsis thaliana
Manually annotated by BRENDA team