1.1.1.102: 3-dehydrosphinganine reductase
This is an abbreviated version!
For detailed information about 3-dehydrosphinganine reductase, go to the full flat file.
Word Map on EC 1.1.1.102
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1.1.1.102
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sphingolipids
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ceramide
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nadph-dependent
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phytosphingosine
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sphingomyelin
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inositolphosphorylceramide
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palmitoyl-coa
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food industry
- 1.1.1.102
- sphingolipids
- ceramide
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nadph-dependent
- phytosphingosine
- sphingomyelin
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inositolphosphorylceramide
- palmitoyl-coa
- food industry
Reaction
Synonyms
3-KDS reductase, 3-ketodihydrosphingosine reductase, 3-ketosphinganine reductase, 3-oxosphinganine reductase, 3-oxosphinganine:NADPH oxidoreductase, 3KDSR, D-3-dehydrosphinganine reductase, D-3-oxosphinganine reductase, D-3-oxosphinganine:B-NADPH oxidoreductase, DSR, FVT-1, Fvt1, h-FTV-1, KDS reductase, Ksr1p, KsrA, m-FTV-1, More, TSC10, TSC10A, Tsc10p
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Engineering
Engineering on EC 1.1.1.102 - 3-dehydrosphinganine reductase
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A175T
additional information
site-directed mutagenesis, naturally occuring missense mutation linked to animals with bovine spinal muscular atrophy. Protein exhibits no detectable in vitro catalytic activity, but the mutated gene complements the growth defect of a homologous yeast knock-out strain as well as the healthy variant
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identification of Arabidopsis thaliana leaf ionomic mutant 7113, termed tsc10a-1. Double mutant progeny plants lacking both genes are not recovered from crosses of single tsc10A and tsc10B mutants. Plant 3-KDS reductase activity is reduced to 10% of wild-type levels in the loss-of-function tsc10a mutant, leading to an altered sphingolipid profile
additional information
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construction of an enzyme-deficient mutant by gene replacement, the mutant produces lower levels of inositolphosphorylceramides
additional information
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mutation of any of the three residues that constitute the catalytic triad of FVT1 do not completely inactivate the enzyme, as it is able to support growth of tsc10DELTA mutant cells at 26°C, but not at 37°C. Deletion of residues 4-26 from the FVT1-GFP protein abolishes ER localization
additional information
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construction of the deletion mutant TscDELTA38p
additional information
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cobstruction of a tsc10 knockout mutant strain, analysis of lipid and ceramide profiles compared to wild-type strain, quantitative real time RT-PCR expression analysis, phenotype, overview
additional information
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cobstruction of a tsc10 knockout mutant strain, analysis of lipid and ceramide profiles compared to wild-type strain, quantitative real time RT-PCR expression analysis, phenotype, overview
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