1.1.1.100: 3-oxoacyl-[acyl-carrier-protein] reductase

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For detailed information about 3-oxoacyl-[acyl-carrier-protein] reductase, go to the full flat file.

Word Map on EC 1.1.1.100

1.1.1.100

enoyl

drug development

transacylase

3-oxoacyl-acyl-carrier-protein

dehydrase

enoyl-acp

3-oxoacyl-acyl

acyl-acps

beta-hydroxyacyl-acp

fas-ii

4'-phosphopantetheine

synthesis

Reaction

a (3R)-3-hydroxyacyl-[acyl-carrier protein]

Synonyms

3-ketoacyl acyl carrier protein reductase, 3-ketoacyl-(acyl-carrier-protein) reductase, 3-ketoacyl-ACP reductase, 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase, 3-ketoacyl-ACP(CoA) reductase, 3-ketoacyl-acyl carrier protein reductase, 3-ketoacyl-thioester reductase, 3-ketoacyl-[acyl-carrier-protein] reductase, 3-oxo-acyl-ACP reductase, 3-oxoacyl-(acyl carrier protein) reductase, 3-oxoacyl-(acyl-carrier-protein) reductase, 3-oxoacyl-ACP reductase, 3-oxoacyl-AcpM reductase, 3-oxoacyl-thioester reductase, 3-oxoacyl-[ACP]reductase, ACP reductase, beta-ketoacyl acyl carrier protein (ACP) reductase, beta-ketoacyl acyl carrier protein reductase, beta-ketoacyl reductase, beta-ketoacyl thioester reductase, beta-ketoacyl-(acyl carrier protein) reductase, beta-ketoacyl-ACP reductase, beta-ketoacyl-acyl carrier protein reductase, beta-ketoacyl-[acyl carrier protein] reductase, beta-ketoacyl-[acyl-carrier protein] (ACP) reductase, BKR, FabG, FabG1, FabG2, fabG3, fabG4, KACPR, KAR, KCR1, KCR2, ketoacyl-acyl carrier protein reductase, MabA, MSMEG_3150, MSMEG_6753, NADPH-dependent acetoacetyl coenzyme A reductase, NADPH-specific 3-oxoacyl-[acylcarrier protein]reductase, OAR, OAR1, Oar1p, PA4389, PA4786, PHA-specific acetoacetyl-CoA reductase, PhaB, pks3, polyhydroxyalkanoate-specific acetoacetyl coenzyme A reductase, reductase, 3-oxoacyl-[acyl carrier protein], RhlG, XCC0416

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.100 3-oxoacyl-[acyl-carrier-protein] reductase

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Results	in table
2	Activating Compound
67911	AA Sequence
31	Application
1	CAS Registry Number
48	Cloned(Commentary)
64	Cofactor
16	Crystallization (Commentary)
41	Disease/ Diagnostics
8	Expression
23	General Information
3	General Stability
25	IC50 Value
83	Inhibitors
6	kcat/KM [mM/s]
3	Ki Value [mM]
73	KM Value [mM]
7	Localization
1	Metals/Ions
29	Molecular Weight [Da]
26	Natural Substrates/ Products (Substrates)
136	Organism
32	Pathway
498	PDB ID
16	pH Optimum
5	pH Range
2	pI Value
1	Posttranslational Modification
41	Protein Variants
39	Purification (Commentary)
7	Reaction
4	Reaction Type
125	Reference
2	Renatured (Commentary)
26	Source Tissue
92	Specific Activity [micromol/min/mg]
8	Storage Stability
179	Substrates and Products (Substrate)
27	Subunits
217	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]
2	Temperature Range [°C]
3	Temperature Stability [°C]
30	Turnover Number [1/s]

Disease

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Disease on EC 1.1.1.100 - 3-oxoacyl-[acyl-carrier-protein] reductase

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Dehydration

The role of FaBG3 in fruit ripening and B. cinerea fungal infection of strawberry.

23802911

Infections

Novel Xanthomonas campestris Long-Chain-Specific 3-Oxoacyl-Acyl Carrier Protein Reductase Involved in Diffusible Signal Factor Synthesis.

29739899

Latent Infection

Inhibition of M. tuberculosis ?-ketoacyl CoA reductase FabG4 (Rv0242c) by triazole linked polyphenol-aminobenzene hybrids: Comparison with the corresponding gallate counterparts.

25666821

Mycoses

The role of FaBG3 in fruit ripening and B. cinerea fungal infection of strawberry.

23802911

Polycystic Kidney Diseases

A C. elegans model for mitochondrial fatty acid synthase II: the longevity-associated gene W09H1.5/mecr-1 encodes a 2-trans-enoyl-thioester reductase.

19924289

Tuberculosis

Advance in Research on Mycobacterium tuberculosis FabG4 and Its Inhibitor.

29946302

Crystal structure of FabG4 from Mycobacterium tuberculosis reveals the importance of C-terminal residues in ketoreductase activity.

21081168

Crystal structure of hexanoyl-CoA bound to ?-ketoacyl reductase FabG4 of Mycobacterium tuberculosis.

23163771

Crystallization and preliminary X-ray diffraction analysis of the high molecular weight ketoacyl reductase FabG4 complexed with NADH.

22750865

Design, synthesis and characterization of dual inhibitors against new targets FabG4 and HtdX of Mycobacterium tuberculosis.

26092447

Design, synthesis and characterization of novel inhibitors against mycobacterial ?-ketoacyl CoA reductase FabG4.

24129589

Functional complementation of the essential gene fabG1 of Mycobacterium tuberculosis by Mycobacterium smegmatis fabG but not Escherichia coli fabG.

17337570

In vitro inhibition of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein reductase MabA by isoniazid.

14693546

Inhibition of M. tuberculosis ?-ketoacyl CoA reductase FabG4 (Rv0242c) by triazole linked polyphenol-aminobenzene hybrids: Comparison with the corresponding gallate counterparts.

25666821

Ligand-induced fit in mycobacterial MabA: the sequence-specific C-terminus locks the conformational change.

15977159

Mycobacterium tuberculosis beta-ketoacyl-ACP reductase: alpha-secondary kinetic isotope effects and kinetic and equilibrium mechanisms of substrate binding.

18155153

Novel katG mutations causing isoniazid resistance in clinical M. tuberculosis isolates.

26251830

Phosphorylation of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein reductase MabA regulates mycolic acid biosynthesis.

20178986

Selection of an Escherichia coli host that expresses mutant forms of Mycobacterium tuberculosis 2-trans enoyl-ACP(CoA) reductase and 3-ketoacyl-ACP(CoA) reductase enzymes.

14766307